VAR2CSA binding phenotype has ancient origin and arose before Plasmodium falciparum crossed to humans: implications in placental malaria vaccine design

Preclinical immunogenicity and safety of the cGMP-grade placental malaria vaccine PRIMVAC

(2019) Arnaud Chêne et al.   EBioMedicine

Genomes of all known members of a Plasmodium subgenus reveal paths to virulent human malaria

(2018) Thomas D. Otto et al.   Nature Microbiology

Down-selection of the VAR2CSA DBL1-2 expressed in E. coli as a lead antigen for placental malaria vaccine development

(2018) Arnaud Chêne et al.   npj Vaccines

Pathogenicity Determinants of the Human Malaria Parasite Plasmodium falciparum Have Ancient Origins

(2017) Andrew J. Brazier et al.   mSphere

Clinical development of placental malaria vaccines and immunoassays harmonization: a workshop report

(2016) Arnaud Chêne et al.   MALARIA JOURNAL

Genomes of cryptic chimpanzee Plasmodium species reveal key evolutionary events leading to human malaria

(2016) Sesh A. Sundararaman et al.   Nature Communications

Structural Conservation Despite Huge Sequence Diversity Allows EPCR Binding by the PfEMP1 Family Implicated in Severe Childhood Malaria

(2015) Clinton K.Y. Lau et al.   Cell Host & Microbe

Ape parasite origins of human malaria virulence genes

(2015) Daniel B. Larremore et al.   Nature Communications

A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum

(2015) Uchechi E. Ukaegbu et al.   PLoS Genetics

The Influence of Sub-Unit Composition and Expression System on the Functional Antibody Response in the Development of a VAR2CSA Based Plasmodium falciparum Placental Malaria Vaccine

(2015) Morten A. Nielsen et al.   PLoS One

Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts

(2014) Thomas D. Otto et al.   Nature Communications

Hypervariable antigen genes in malaria have ancient roots

(2013) Martine M Zilversmit et al.   BMC EVOLUTIONARY BIOLOGY

Severe malaria is associated with parasite binding to endothelial protein C receptor

(2013) Louise Turner et al.   NATURE

DC8 and DC13 var Genes Associated with Severe Malaria Bind Avidly to Diverse Endothelial Cells

(2013) Marion Avril et al.   PLoS Pathogens

Structural and Functional Insight into How thePlasmodium falciparumVAR2CSA Protein Mediates Binding to Chondroitin Sulfate A in Placental Malaria

(2012) Thomas M. Clausen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chondroitin Sulfate A-binding Site of the VAR2CSA Protein Involves Multiple N-terminal Domains

(2011) Madeleine Dahlbäck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Positive Selection of Plasmodium falciparum Parasites With Multiple var2csa-Type PfEMP1 Genes During the Course of Infection in Pregnant Women

(2011) Adam F. Sander et al.   JOURNAL OF INFECTIOUS DISEASES

Var2CSA Minimal CSA Binding Region Is Located within the N-Terminal Region

(2011) Anand Srivastava et al.   PLoS One

Origin of the human malaria parasite Plasmodium falciparum in gorillas

(2010) Weimin Liu et al.   NATURE

Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA

(2010) A. Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple var2csa-Type PfEMP1 Genes Located at Different Chromosomal Loci Occur in Many Plasmodium falciparum Isolates

(2009) Adam F. Sander et al.   PLoS One