Article
Biochemistry & Molecular Biology
Nadia Abu Samra, Herbert F. Jelinek, Habiba Alsafar, Farah Asghar, Muhieddine Seoud, Shahad M. Hussein, Hisham M. Mubarak, Siddiq Anwar, Mashal Memon, Nariman Afify, Ridda Manzoor, Zahrah Al-Homedi, Wael Osman
Summary: Gestational diabetes mellitus is a common complication during pregnancy, caused by genetic, epigenetic, and environmental factors. However, its underlying mechanisms are still unclear, and molecular research in this field is lagging. Early detection of metabolic changes and related genetic and epigenetic factors is crucial for predicting adverse pregnancy outcomes and future pathologies in GDM women and their children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Huiqin Guo, Haili Wu, Zhuoyu Li
Summary: Diabetes is a common metabolic disorder that greatly affects health systems worldwide. Type 2 diabetes accounts for 90% of all cases, and hyperglycemia is its main characteristic. Understanding the molecular processes involved in diabetes development is crucial for improving clinical care.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Noelle A. Sterling, Jun Young Park, Raehee Park, Seo-Hee Cho, Seonhee Kim
Summary: Entosis, a process of cell cannibalism observed in cancer, is also found to play a role in brain development and contribute to microcephaly. The study shows that mutant mice for the microcephaly-causing gene Pals1 exhibit cell-in-cell structures and abnormal mitosis, which can be eliminated by ROCK inhibition. The removal of Trp53 gene also rescues cortical size and reduces cell-in-cell structures and cell death.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Zahra Chinipardaz, Min Liu, Dana Graves, Shuying Yang
Summary: This study revealed that type 1 diabetes impairs fracture healing by affecting primary cilia expression and formation in osteoblasts. Loss of primary cilia in osteoblasts due to diabetes resulted in defective fracture healing, characterized by delayed healing, reduced bone density and mechanical strength.
Review
Biochemistry & Molecular Biology
Mahvash Sadeghi, Sajad Dehnavi, Mojtaba Shohan, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: Diabetes mellitus is a metabolic disorder characterized by high blood sugar levels and complications in multiple organ systems. Its incidence and prevalence are rapidly increasing worldwide. Besides environmental factors, epigenetic and post-translational modifications play critical roles in the pathogenesis of diabetes and its complications. SUMOylation, a reversible covalent modification carried out by SUMO, has emerged as a new mechanism affecting protein regulation. This review focuses on the function of SUMO and SUMOylation, as well as their potential effects on the pathogenesis of type 1 and type 2 diabetes mellitus.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Xi He, Chenshu Liu, Jiangyun Peng, Zilun Li, Fang Li, Jian Wang, Ao Hu, Meixiu Peng, Kan Huang, Dongxiao Fan, Na Li, Fuchun Zhang, Weiping Cai, Xinghua Tan, Zhongwei Hu, Xilong Deng, Yueping Li, Xiaoneng Mo, Linghua Li, Yaling Shi, Li Yang, Yuanyuan Zhu, Yanrong Wu, Huichao Liang, Baolin Liao, Wenxin Hong, Ruiying He, Jiaojiao Li, Pengle Guo, Youguang Zhuo, Lingzhai Zhao, Fengyu Hu, Wenxue Li, Wei Zhu, Zefeng Zhang, Zeling Guo, Wei Zhang, Xiqiang Hong, Weikang Cai, Lei Gu, Ziming Du, Yang Zhang, Jin Xu, Tao Zuo, Kai Deng, Li Yan, Xinwen Chen, Sifan Chen, Chunliang Lei
Summary: Insulin resistance, hyperglycemia, and decreased HDL-C were found in COVID-19 patients without pre-existing metabolic diseases, with increased expression of REST by SARS-CoV-2 infection being the mechanistic link. Specific lipids were identified as potential biomarkers of COVID-19-induced metabolic dysregulation, especially in insulin resistance.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Surgery
Christian J. Carlsson, Kirsten Norgaard, Anne-Britt Oxboll, Mette I. V. Sogaard, Michael P. Achiam, Lars N. Jorgensen, Jonas P. Eiberg, Henrik Palm, Helge B. D. Sorensen, Christian S. Meyhof, Eske K. Aasvang
Summary: This study investigated the frequency and duration of hypo- and hyperglycemia during and after major surgery, using continuous glucose monitoring (CGM) in departments with implemented diabetes care protocols. The results showed that despite protocolized perioperative diabetes management, significant proportions of patients, especially those with diabetes, experienced both hypo- and hyperglycemia during the postoperative period.
Review
Biology
Sasha Smith, Pasha Normahani, Tristan Lane, David Hohenschurz-Schmidt, Nick Oliver, Alun Huw Davies
Summary: This article discusses the pathogenesis of DSPN, the successes and limitations of current therapies, and potential therapeutic targets. Recent research findings have called into question the definition of DSPN and transformed the disease model.
Article
Food Science & Technology
Meifang Wu, Naying Zheng, Xiaoxiao Zhan, Jianzhang He, Min Xiao, Zhenghong Zuo, Chengyong He
Summary: This study demonstrates that Icariin may cause developmental toxicity by disrupting thyroid development and hormone synthesis, highlighting the importance of risk assessments in clinical practice.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yong Kwon Han, Ji Su Kim, GiBong Jang, Kwon Moo Park
Summary: Cisplatin induces lung cell damage, ciliary fragmentation, and increased oxidative stress, but these effects can be prevented by the mitochondria-specific antioxidant Mito-TEMPO.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Plant Sciences
Mikinori Ueno, Ryusho Kariya, Gunya Sittithumcharee, Seiji Okada
Summary: The study demonstrated that cucurbitacin B (CuB) can effectively inhibit cell proliferation and induce apoptosis in Primary Effusion Lymphoma (PEL) cells in a dose-dependent manner. CuB also has an impact on cell cycle arrest and affects signaling pathways related to KSHV-derived protein activation. In vivo experiments showed that CuB significantly inhibited solid tumor growth, indicating its potential as a promising agent for PEL treatment.
Article
Multidisciplinary Sciences
Kun Yang, Min Fan, Xiaohui Wang, Jingjing Xu, Yana Wang, P. Spencer Gill, Tuanzhu Ha, Li Liu, Jennifer Hall, David L. Williams, Chuanfu Li
Summary: Circulating lactate levels are closely associated with the severity and mortality of sepsis. Our study reveals that lactate contributes to endothelial barrier dysfunction in sepsis, leading to increased vascular permeability and organ dysfunction. Mechanistically, lactate activates the ERK pathway, resulting in proteolytic cleavage and enhanced endocytosis of VE-cadherin in endothelial cells. We also demonstrate the regulatory role of lactate in the interaction between ERK2 and VE-cadherin, which further affects endothelial stability. Inhibition of lactate production or depletion of lactate receptor GPR81 mitigates sepsis-induced vascular permeability, organ injury, and improves patient survival.
Review
Biochemical Research Methods
Bhaswati Chatterjee, Kudugunti Neelaveni, Himaja Kenchey, Suman S. Thakur
Summary: This study provides detailed information about a series of signaling pathways and protein-protein interactions involved in the pathogenesis of gestational diabetes mellitus (GDM), and evaluates their role in GDM development. The study found protein-protein interactions between proteins of different signaling pathways, suggesting an interlink between these pathways. Dysregulation of signaling pathways may contribute to increased risk of GDM-related complications in both mother and child.
Article
Cell Biology
Jin Cheng, Xiaoning Duan, Xin Fu, Yanfang Jiang, Peng Yang, Chenxi Cao, Qi Li, Jiying Zhang, Xiaoqing Hu, Xin Zhang, Yingfang Ao
Summary: The study shows that RIP1 plays a crucial role in the onset and progression of osteoarthritis (OA) by mediating chondrocyte necroptosis and disrupting extracellular matrix (ECM) metabolism. Inhibition of RIP1 activity protects rats from cartilage degradation and limb pain, and bone morphogenetic protein 7 (BMP7) is identified as a downstream target that mediates RIP1-induced chondrocyte necroptosis and OA manifestations. This provides a new therapeutic target for OA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Haiyan Xu, Jingyi Li, Luyang Jin, Dan Zhang, Bin Chen, Xinmei Liu, Xianhua Lin, Yiting Huang, Zhanghong Ke, Juan Liu, Lin Gao, Jianzhong Sheng, Hefeng Huang
Summary: Diabetes can adversely affect reproductive function and lead to abnormal SGK1 expression in the endometrium. Enhanced expression of SGK1 in a high-glucose environment further reduces embryo implantation and causes aberrant expression of LIF and MUC1.
SCIENCE CHINA-LIFE SCIENCES
(2022)
