Article
Neurosciences
Rie Tohge, Satoshi Kaneko, Satoshi Morise, Mitsuaki Oki, Norihiro Takenouchi, Aya Murakami, Masataka Nakamura, Hirofumi Kusaka, Yusuke Yakushiji
Summary: The neurotransmitters glutamate, GABA, acetylcholine, dopamine, and serotonin interact in the striatum to regulate neural information flow. Zonisamide has been shown to improve Parkinson's disease patients' off periods without worsening levodopa-induced dyskinesia. Analyzing changes in serotonergic neurotransmission in LID model rats reveals that the anti-dyskinetic effects of ZNS are based on inhibition via 5HT1B receptors.
Article
Clinical Neurology
Valtteri Kaasinen, Sheng Luo, Pablo Martinez-Martin, Christopher G. G. Goetz, Glenn T. T. Stebbins
Summary: This study compared patient and clinician evaluations of levodopa-induced dyskinesia (LID) severity across multiple cultures in patients with Parkinson's disease (PD). The results showed that language and cultural differences influence the subjective perception of LID, which is important to consider in multinational clinical trials on dyskinesia assessment.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Qian-Ya Fan, Xiao-Dong Zhang, Ze-Di Hu, Shi-Shi Huang, Shi-Guo Zhu, Cai-Ping Chen, Xiong Zhang, Jian-Yong Wang
Summary: This case report presents a patient with Parkinson's disease who developed blepharospasm during the peak-dose dyskinesia period. The symptom was improved by taking amantadine. This expands the understanding of peak-dose dyskinesia in Parkinson's disease to include dystonic blepharospasm, which may respond to amantadine despite the dystonic appearance of movements.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Piniel Alphayo Kambey, Wen Ya Liu, Jiao Wu, Chuanxi Tang, Wokuheleza Buberwa, Adonira Saro, Alphonce M. K. Nyalali, Dianshuai Gao
Summary: This study revealed the crucial role of Amphiregulin (Areg) gene in levodopa-induced dyskinesia in Parkinson's disease. Inhibition of Areg was found to alleviate dyskinetic movements and decrease the expression of related proteins. Therefore, Areg may serve as a potential target for therapy development.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Multidisciplinary Sciences
Clara Virbel-Fleischman, Yann Retory, Sebastien Hardy, Camille Huiban, Jean-Christophe Corvol, David Grabli
Summary: This study evaluated the usability, user experience, patients' perceptions, and health professionals' opinions on Body-Worn Sensors (BWS) monitoring for Parkinson's disease. Both patients and professionals expressed interest in BWS monitoring, with patients having high hopes and expectations for its potential to improve their symptoms. However, there are gaps that need to be addressed to facilitate the adoption and promotion of BWS.
Article
Computer Science, Artificial Intelligence
E. Balaji, D. Brindha, Vinodh Kumar Elumalai, R. Vikrama
Summary: Deep learning has significant potential in healthcare for diagnosing various diseases by analyzing large volumes of clinical data. A novel deep learning architecture based on the LSTM network is proposed to evaluate the severity of Parkinson's disease, achieving reliable diagnosis by learning long-term temporal dependencies in the gait cycle.
APPLIED SOFT COMPUTING
(2021)
Review
Mathematical & Computational Biology
Peng Li, Richard van Wezel, Fei He, Yifan Zhao, Ying Wang
Summary: Parkinson's disease (PD) is a widespread neurodegenerative disorder that presents challenges for timely diagnosis. Wrist-worn digital devices, particularly smartwatches, are popular tools in PD research due to their convenience for long-term monitoring. However, the value of wrist-worn sensing devices for daily practice is still uncertain.
FRONTIERS IN NEUROINFORMATICS
(2023)
Article
Geriatrics & Gerontology
Jinyoung Youn, Mansu Kim, Suyeon Park, Ji Sun Kim, Hyunjin Park, Jin Whan Cho
Summary: This study investigates the structural changes in the basal ganglia related to levodopa-induced dyskinesia (LID) in Parkinson's disease (PD). The results demonstrate distinct shape alterations, especially in the globus pallidus interna (GPi), in the LID group compared to the non-LID group. These findings suggest the crucial role of the basal ganglia pathway in the development of LID.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Bruno L. Santos-Lobato, Luiz Gustavo Gardinassi, Mariza Bortolanza, Ana Paula Ferranti Peti, Angela V. Pimentel, Lucia Helena Faccioli, Elaine A. Del-Bel, Vitor Tumas
Summary: Metabolomic analysis revealed a distinct metabolic profile associated with levodopa-induced dyskinesia (LID) in Parkinson's disease (PD), particularly characterized by dysregulation of the glycosphingolipid metabolic pathway and bile acid biosynthesis metabolites in plasma and CSF. These findings suggest a potential link between lipid metabolism dysregulation and LID in PD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Ghorban Taghizadeh, Mohammad Taghi Joghataei, Sepideh Goudarzi, Merat Bakhsheshi, Sayed Amir Hasan Habibi, Maryam Mehdizadeh
Summary: The study confirmed the acceptability and efficacy of the Persian version of KPPS-P for assessing pain in patients with Parkinson's disease. Cut-off points for pain severity levels were identified as 0, 17, and 68, with high sensitivity and specificity.
NEUROSCIENCE LETTERS
(2021)
Article
Chemistry, Analytical
James R. Williamson, Brian Telfer, Riley Mullany, Karl E. Friedl
Summary: By analyzing wrist-worn accelerometry data from the U.K. Biobank, machine learning classifiers detected PD with AUC of 0.69 on gait data, 0.84 on low-movement data, and 0.85 on a fusion of both activities over one week. The study found that classification accuracy improved steadily during the one-week data collection, suggesting the potential for higher accuracy with longer data collection. These findings support the feasibility of using a cost-effective and user-friendly activity sensor for detecting movement abnormalities related to PD and further research on early PD detection and symptom severity tracking.
Review
Cell Biology
Destany K. K. Kwon, Mohit Kwatra, Jing Wang, Han Seok Ko
Summary: Levodopa is the most commonly used treatment for Parkinson's disease (PD) but comes with side effects in the advanced stages of the disease. Understanding the pathological mechanisms of levodopa-induced dyskinesia (LID) and finding alternative treatment options are crucial for improving the outcome of PD patients.
Article
Neurosciences
Jingsheng Yang, Quanhao Guo, Xianwei Zou, Meng Wang, Yanxia Wen, Xiaqing Chen, Xiechuan Weng, Fan Xu
Summary: The study found that the range of head tremor in Parkinson's disease patients is positively correlated with the severity of the disease, with significantly greater head displacement compared to healthy individuals, and positively correlated with the severity of the disease.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Geriatrics & Gerontology
Yan Qu, Tingting Zhang, Yunyan Duo, Liling Chen, Xiaohong Li
Summary: This study aims to investigate the value of the Parkinson's KinetiGraph (PKG) in identifying and quantitatively assessing motor complications in the Chinese PD population and its correlation with clinical assessments. The study found that PKG has a significant correlation with clinical assessment, high sensitivity, and high specificity, providing an objective and quantitative method for identifying and assessing motor complications in Parkinson's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Health Care Sciences & Services
Md Saiful Islam, Wasifur Rahman, Abdelrahman Abdelkader, Sangwu Lee, Phillip T. Yang, Jennifer Lynn Purks, Jamie Lynn Adams, Ruth B. Schneider, Earl Ray Dorsey, Ehsan Hoque
Summary: Researchers developed an AI system to remotely assess motor performance in individuals with Parkinson's disease. They used a standardized finger-tapping task performed by 250 participants worldwide and had expert neurologists rate the recorded videos. The computer algorithms developed aligned with the neurologists' ratings and outperformed certified raters.
NPJ DIGITAL MEDICINE
(2023)
Article
Engineering, Biomedical
Dean Sweeney, Leo R. Quinlan, Patrick Browne, Timothy Counihan, Alejandro Rodriguez-Molinero, Gearoid OLaighin
Summary: This study aimed to investigate the applicability and tolerability of sensory and motor electrical stimulation in people with Parkinson's disease. Results showed that sensory electrical stimulation was applicable and tolerable in lower leg sites for most participants, while the tolerability of motor electrical stimulation varied.
MEDICAL ENGINEERING & PHYSICS
(2021)
Letter
Clinical Neurology
Dean Sweeney, Leo R. Quinlan, Margaret Richardson, Pauline Meskell, Anne-Louise Cunnington, Lois Rosenthal, Lan Luo, Gearoid Olaighin
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Health Care Sciences & Services
Kevin A. Cradock, Leo R. Quinlan, Francis M. Finucane, Heather L. Gainforth, Kathleen A. Martin Ginis, Ana Correia de Barros, Elizabeth B. N. Sanders, Gearoid OLaighin
Summary: This study investigated the perceived barriers and facilitators to diet and physical activity behavior change in individuals with Type 2 Diabetes. Data was collected using Design Probes and a thematic analysis revealed key factors influencing behavior change in this population.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Medicine, General & Internal
Shauna McBride, Sahar Avazzadeh, Antony M. Wheatley, Barry O'Brien, Ken Coffey, Adnan Elahi, Martin O'Halloran, Leo R. Quinlan
Summary: Targeted cellular ablation is increasingly used for the treatment of arrhythmias and structural heart disease. Electroporation disrupts cell membranes with minimal thermal effects, creating temporary or permanent nanopores. Further research is needed to understand the specificity of electroporation thresholds for different cell types in complex tissues.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Sahar Avazzadeh, Barry O'Brien, Ken Coffey, Martin O'Halloran, David Keane, Leo R. Quinlan
Summary: The study aimed to compare the optimal voltage thresholds for different cell types within the cardiovascular system and selective cell ablation. Results showed that neuronal and atrial cardiomyocyte lines had cell viabilities below 20% at 1000 V/cm, while cardiac fibroblasts showed an optimal threshold at 1250 V/cm.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Analytical
Kevin A. Cradock, Leo R. Quinlan, Francis M. Finucane, Heather L. Gainforth, Kathleen A. Martin Ginis, Elizabeth B-N Sanders, Gearoid OLaighin
Summary: This study focuses on individual-level diet behavior and describes the design of a tool to support diet behavior change in persons with type 2 diabetes. The tool was designed using a human-centered design methodology and the Behavior Change Wheel framework, aiming to gradually change diet behavior over a 12-week period.
Article
Cardiac & Cardiovascular Systems
Sahar Avazzadeh, Mahshid H. Dehkordi, Peter Owens, Amirhossein Jalali, Barry O'Brien, Ken Coffey, Martin O'Halloran, Howard O. Fernhead, David Keane, Leo. R. Quinlan
Summary: This study presents important findings on the differences in the susceptibility of neurons and cardiomyocytes to irreversible electroporation. Cell type alone yielded selective and different dynamics in terms of the evolution and signaling mechanism of cell death in response to electroporation.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Alejandro Rodriguez-Molinero, Antonio Minarro, Leire Narvaiza, Cesar Galvez-Barron, Natalia Gonzalo Leon, Esther Valldosera, Eva De Mingo, Oscar Macho, David Aivar, Efren Pinzon, Adilis Alba, Jorge Passarelli, Nadia Stasi, Isabel Collado, Jose R. Banegas
Summary: This study examines whether blood pressure-lowering drugs are associated with an increased risk of death in elderly patients, taking multiple potential confounders into account. The results indicate a significant association between diuretics and nitrites and mortality.
INTERNATIONAL JOURNAL OF HYPERTENSION
(2022)
Article
Engineering, Industrial
Evismar Andrade, Leo R. Quinlan, Richard Harte, Bronwyn Reid-McDermott, Frank Kirrane, Enda Fallon, Martina Kelly, Tony Hall, Michael Scully, John Laffey, Patrick Pladys, Ethel Ryan, Dara Byrne, Gearoid OLaighin
Summary: This study developed an online training platform to train clinicians on the use of a critical care medical device and carried out a preliminary evaluation of the platform via a case study. The results showed that participants were able to use and interpret the device interface and were overall satisfied with the training platform, perceiving it as an efficient and effective method for training.
APPLIED ERGONOMICS
(2023)
Article
Biochemistry & Molecular Biology
Enrico Bagnoli, Alexandre Trotier, Jill Mcmahon, Leo R. Quinlan, Manus Biggs, Abhay Pandit, Una Fitzgerald
Summary: Parkinson's disease is a progressive neurodegenerative disorder with unknown etiology and no cure. The olfactory bulb, responsible for processing olfactory information, is affected early in the disease. Research has shown that exposure to the dopamine metabolite DOPAL can replicate many aspects of Parkinson's disease pathology.
Article
Biochemistry & Molecular Biology
Enrico Bagnoli, Alexandre Trotier, Jill McMahon, Leo R. Quinlan, Manus Biggs, Abhay Pandit, Una Fitzgerald
Summary: Parkinson's disease is a progressive neurodegenerative disorder with unknown etiology and no cure. The olfactory bulb, involved in processing olfactory information, is affected early in the disease. The study demonstrates that dopamine metabolite DOPAL can replicate Parkinson's pathology, shedding light on the disease mechanism.
Article
Cardiac & Cardiovascular Systems
Jara M. Baena-Montes, Tony O'Halloran, Cormac Clarke, Kevin Donaghey, Eoghan Dunne, Martin O'Halloran, Leo R. Quinlan
Summary: This study aims to determine the optimal ablation threshold parameters related to lesion size for human cardiomyocytes in 2D culture. The results showed that human cardiomyocytes are susceptible to significant electroporation and cell death at a field strength of 750 V/cm or higher with 100 mu s pulses. Increasing the IRE on-time from 3 ms to 60 ms reduces the effective field threshold to 250 V/cm. The study also predicted different forms of cell death based on the evolution of cell death over time.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Medicine, General & Internal
Alejandro Rodriguez-Molinero, Jorge Hernandez-Vara, Antonio Minarro, Carlos Perez-Lopez, Angels Bayes-Rusinol, Juan Carlos Martinez-Castrillo, David A. Perez-Martinez
Summary: This study aims to compare the effectiveness of the Parkinson's Holter with traditional clinical practice in reducing Off time, as well as analyzing other motor complications, quality of life, autonomy in activities of daily living, adherence to the monitoring system, and number of doctor-patient contacts.
Article
Engineering, Biomedical
Peadar R. Rooney, Vijaya Krishna Kannala, Niranjan G. Kotla, Ana Benito, Damien Dupin, Iraida Loinaz, Leo R. Quinlan, Yury Rochev, Abhay Pandit
Summary: The study successfully engineered a biphasic system using cross-linked hyaluronic acid and naive HA solution to treat interstitial cystitis, reducing inflammation and permeability. The biphasic system demonstrated therapeutic effects by increasing the barrier effect through decreased permeability and alteration of cell metabolism.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)