Article
Biochemistry & Molecular Biology
Sultan Ahmed, W. Todd Miller
Summary: This study demonstrates that the noncatalytic regions of Tnk1 play important roles in governing activity and substrate phosphorylation, including the importance of the N-terminal SAM domain for self-association and kinase activity, and the role of the C-terminus in the subcellular localization of the kinase.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Oncology
Corinna Haist, Zoe Poschinski, Arthur Bister, Michele J. Hoffmann, Camilla M. Grunewald, Alexandra Hamacher, Matthias Kassack, Constanze Wiek, Kathrin Scheckenbach, Helmut Hanenberg
Summary: The study successfully generated a high-affinity EGFR CAR construct and demonstrated its efficacy and specificity in combating head and neck squamous cell carcinoma and other solid cancers.
Article
Biochemistry & Molecular Biology
Tasuku Nishino, Tsuyoshi Oshika, Moriatsu Kyan, Hiroaki Konishi
Summary: The study investigated the subcellular localization of GAREM1 and GAREM2 in response to cell growth stimulus. It was found that GAREM2 specifically formed granules in response to NGF and EGF stimulation, and a glycine-rich region in GAREM2 was required for this granule formation. This aggregation of GAREM2 may be linked to neurodegenerative diseases.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Multidisciplinary Sciences
Hanshuang Shao, Alan Wells
Summary: In this study, it was found that ACTN4 is rapidly phosphorylated upon EGF treatment through direct interaction with EGFR. Overexpression of EGFR also enhances the phosphorylation of ACTN4.
Article
Cell Biology
Rohan Prasad Surabhi, Swetha Rajendran, B. Srikanth Swamy Swaroop, Sowmiya Murugan, Gouthaman Shanmugasundaram, Leena Dennis Joseph, Ravishankar Pitani, Pakala Suresh Babu, K. Rayala Suresh, Ganesh Venkatraman
Summary: Head and neck squamous cancers (HNSCC) are aggressive tumors with poor prognosis. The expression and activation of oncogenic signaling kinase P21 activated kinase-1 (PAK1) in HNSCC cells are associated with accelerated tumorigenic character and poor survival. Silencing PAK1 could be a potential treatment modality for improving clinical outcomes in HNSCC.
CELLULAR SIGNALLING
(2023)
Article
Biology
Xiaolong Tang, Lizhi Cheng, Guo Li, Yong-Ming Yan, Fengting Su, Dan-Ling Huang, Shuping Zhang, Zuojun Liu, Minxian Qian, Ji Li, Yong-Xian Cheng, Baohua Liu
Summary: The small molecule compound D6 demonstrates promising efficacy in treating EGFR-TKI resistant NSCLC by targeting the protein-protein interaction between HSP90 and T790M-EGFR, offering a potential alternative strategy to overcome drug resistance.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Marco A. Alfonzo-Mendez, Kem A. Sochacki, Marie-Paule Strub, Justin W. Taraska
Summary: The study reveals the interaction between growth factor signaling and cell adhesion, and highlights the role of flat clathrin lattices in enhancing signal transduction.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Muhammad Irfan, Seung Chung
Summary: Tissue injury triggers an immune response and inflammation, and the complement system plays a role in the regeneration process. C5a receptor (C5aR) and C5a-like receptor 2 (C5AR2; C5L2) have been found to be involved in nerve sprouting and tissue formation. This study explores the role of C5L2 in regulating BDNF secretion in human dental pulp stem cells (DPSCs) and suggests its potential in accelerating nerve regeneration.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
David A. Hernandez-Espinosa, Rocio Alcantara-Hernandez, K. Helivier Solis, J. Adolfo Garcia-Sainz
Summary: By substituting phosphorylation sites with non-phosphorylatable amino acids, the function of the alpha(1B)-adrenergic receptor phosphorylation sites in mediating receptor function was evaluated. The results showed that phosphorylation sites in the IL3 and Ctail domains play a significant role in regulating receptor function and mediating desensitization in response to phorbol ester.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Caihua Zhang, Zhi Chen, Nailin Gao, Gan Xiong, Peng Chen, Hui Li, Demeng Chen, Qianting He, Liang Peng
Summary: In this study, resistant Bmi1-expressing cells were found during cetuximab treatment, and a novel role of SOX18 in promoting cetuximab resistance in head and neck squamous cell carcinoma (HNSCC) was reported. The study aimed to investigate the regulatory mechanism of Sox18 in Bmi1-positive cells and to search for better therapeutic targets.
Review
Endocrinology & Metabolism
Lorena Gonzalez, Maria E. Diaz, Johanna G. Miquet, Ana I. Sotelo, Fernando P. Dominici
Summary: The interaction between EGFR and GH in the liver plays a significant role in the development and progression of liver tumors, with factors such as exposure to supraphysiological GH levels and the pattern of GH administration being important variables to consider.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biology
Chi-Chuan Lin, Lukasz Wieteska, Guillaume Poncet-Montange, Kin Man Suen, Stefan T. Arold, Zamal Ahmed, John E. Ladbury
Summary: Interactions between the peripheral juxtamembrane and C-terminal tail regions and the phosphorylation state of the kinase domain of FGFR2 fine tunes its signaling outputs.
COMMUNICATIONS BIOLOGY
(2023)
Article
Oncology
Zeng Qi, Yue Qiu, Zhaohui Wang, Huiping Zhang, Ling Lu, Yanqiu Liu, David Mathes, Elizabeth A. Pomfret, Dexiang Gao, Shi-Long Lu, Zhirui Wang
Summary: The novel bivalent human epidermal growth factor fusion toxin (Bi-EGF-IT) shows increased binding affinity and treatment specificity for EGFR-expressing HNSCC compared to the monovalent version and erlotinib, demonstrating superior efficacy in inhibiting primary HNSCC tumor growth and metastasis with reduced off-target toxicities.
MOLECULAR ONCOLOGY
(2021)
Article
Cell Biology
Hsuan-Hsiang Peng, Hao-Chin Yang, Darius Rupa, Chun-Han Yen, Ya-Wen Chiu, Wei-Jia Yang, Fuh-Jinn Luo, Ta-Chun Yuan
Summary: This study investigated the oncogenic role of ACK1 and its underlying molecular mechanism in head and neck squamous cell carcinoma. The results demonstrated that ACK1 is highly expressed in HNSCC tumors and promotes cell proliferation by phosphorylating and degrading p27.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2022)
Article
Cell Biology
Zhe Yang, Zhengyang Feng, Zebin Li, Rohan D. Teasdale
Summary: The mammalian retromer complex plays a role in multiple early endosome-associated trafficking pathways, depending on the sorting nexin (SNX) it is complexed with. Depletion of retromer subunit Vps35 was found to decrease EGFR protein levels and increase association with lysosomal compartments. This study suggests that the absence of retromer can interfere with early endosome-associated protein trafficking pathways and organelle maturation, leading to a prolonged association of EGFR within early endosomes.
Article
Otorhinolaryngology
Joerdis Kristin Eden, Arne Boettcher, Christian Stephan Betz
Summary: Congenital anterior skull base defects with meningoencephaloceles causing nasal obstruction and cerebrospinal fluid (CSF) rhinorrhea are rare clinical entities. The use of transnasal endoscopic technique is a minimally invasive, efficient, and safe approach even in the infant population.
ENT-EAR NOSE & THROAT JOURNAL
(2023)
Article
Oncology
Mara Borgmann, Agnes Oetting, Felix Meyer, Nikolaus Mockelmann, Conrad Droste, Clara Marie von Bargen, Christina Moeller-Koop, Melanie Witt, Kerstin Borgmann, Kai Rothkamm, Christian Betz, Adrian Munscher, Till Sebastian Clauditz, Thorsten Rieckmann
Summary: This study evaluated the prognostic impact of B7-H3 and B7-H4 in head and neck squamous cell carcinoma (HNSCC) patients. The results showed that B7-H3 was associated with better overall survival in HPV-negative HNSCC. However, mRNA levels of B7-H3 and B7-H4 were not significantly associated with patient survival. These findings provide clues for further investigating the mechanisms and potential targeting of B7-H3.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Otorhinolaryngology
Anh Thu Vu, Lara Akingunsade, Konstantin Hoffer, Cordula Petersen, Christian Stephan Betz, Kai Rothkamm, Thorsten Rieckmann, Lara Bussmann, Malte Kriegs
Summary: The study demonstrates the potential benefits of SFK inhibition in HNSCC, but highlights the challenges due to non-specific effects of different drugs.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Meryem H. H. Cetin, Thorsten Rieckmann, Konstantin Hoffer, Britta Riepen, Sabrina Christiansen, Fruzsina Gatzemeier, Simon Feyerabend, Melanie Schoof, Ulrich Schueller, Cordula Petersen, Martin Mynarek, Kai Rothkamm, Malte Kriegs, Nina Struve
Summary: In this study, the researchers found that high expression of Wee1 kinase is associated with poor prognosis in glioblastoma. They demonstrated that inhibition of Wee1 can sensitize glioblastoma cells to radiotherapy, regardless of the expression of EGFRvIII.
RADIATION ONCOLOGY
(2023)
Article
Otorhinolaryngology
Mihnea Cristian Trache, Josef Maria Heinrich Schipp, Mareike Haack, Christine Adderson-Kisser, Catalina Hoegerle, Sven Becker, Christian Stephan Betz
Summary: This study investigates the impact of etiology on the epidemiologic profile, disease severity, type of treatment and therapy outcome in smell and taste disorders. The results show that post-traumatic etiology is associated with young age and male sex, and has the most severe degrees of smell loss. Postinfectious causes are more frequent in females and correlate with a history of pharyngeal surgery. Sinunasal etiology with nasal polyps worsens the overall olfactory test score, but shows significant improvement after therapy. Good correlations between subjective impairment and objective dysfunction were established for each sensory modality.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Florian Jansen, Christian Stephan Betz, Matthias Hans Belau, Gesa Matnjani, Till Sebastian Clauditz, Sebastian Dwertmann-Rico, Katharina Stoelzel, Nikolaus Moeckelmann, Arne Boettcher
Summary: This study aimed to determine the effect of omitting postoperative irradiation of the contralateral pathologically node-negative neck on oncological outcomes in oropharyngeal squamous cell carcinoma patients. Retrospective analysis showed that omitting the irradiation did not decrease tumor-free, cause-specific, or overall survival. Unilateral postoperative irradiation was associated with increased overall survival and cause-specific survival, especially for tumors arising from lymphoepithelial tissue.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Henrike B. Zech, Christian S. Betz
Summary: Based on the studies presented at the ASCO and ESMO meetings in 2022, changes in the clinical routine of nasopharyngeal, salivary gland, and thyroid cancer were suggested. Therapeutic innovations for specialized otorhinolaryngological tumor entities were assessed, focusing on their potential clinical relevance. The studies presented at the conferences analyzed clinical phase II and phase III trials and highlighted the importance of risk-adapted treatment strategies and targeted therapies for advanced cancers in these areas.
Article
Biochemistry & Molecular Biology
Rupert Stadlhofer, Manuela Moritz, Marceline M. Fuh, Jorg Heeren, Henrike Zech, Till S. Clauditz, Hartmut Schlueter, Christian S. Betz, Dennis Eggert, Arne Boettcher, Jan Hahn
Summary: Nanosecond infrared laser tissue sampling combined with mass spectrometry lipidomic analysis is a feasible and promising approach for differentiating oropharyngeal squamous cell carcinoma from non-tumorous oropharyngeal tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Otorhinolaryngology
H. B. Zech, C. S. Betz, T. K. Hoffmann, J. P. Klussmann, T. Deitmer, O. Guntinas-Lichius
Summary: The ORATOR2 trial investigated therapy de-escalation in early human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas (OPSCC). The study compared radiotherapy with trans-oral surgery and neck dissection in 61 patients. The primary endpoint favored radiotherapy, but the trial had limitations and caution should be exercised in drawing conclusions for clinical practice.
LARYNGO-RHINO-OTOLOGIE
(2023)
Review
Oncology
Kristina Viktorsson, Thorsten Rieckmann, Maximilian Fleischmann, Markus Diefenhardt, Stephanie Hehlgans, Franz Roedel
Summary: Recent advances in understanding tumor biology and innovative technologies have led to individual characterization of malignancies, providing a basis for personalized cancer treatment. Studies on radiation-induced signaling and tumor promotion have identified novel molecular targets. However, only a limited number of clinical trials have shown improved outcomes with the combination of radiation therapy or chemoradiation therapy and targeted agents. This review highlights recent progress in molecular therapies targeting oncogenic drivers, DNA damage response, apoptosis signaling pathways, and the tumor microenvironment to enhance radiation response, as well as advancements in nanotechnology for targeted therapy.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Psychology, Multidisciplinary
Theresa Schrage, Mirja Goerlach, Christian Stephan Betz, Carsten Bokemeyer, Nicolaus Kroeger, Volkmar Mueller, Andreas Kruell, Holger Schulz, Christiane Bleich
Summary: The purpose of this study was to evaluate the psychometric properties and item reduction of a newly developed questionnaire for measuring health-related quality of life in cancer patients. The results showed that the HELP-6 questionnaire has a six-factor structure and demonstrated moderate-to-good convergent validity and test-retest reliability. The conclusion is that the HELP-6 is a short and practical patient-reported outcome instrument that provides important information in relevant dimensions of health-related quality of life in cancer patients.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Oncology
Fridolin Grottker, Simon Gehre, Clara M. Reichardt, Azzaya Sengedorj, Tina Jost, Thorsten Rieckmann, Markus Hecht, Antoniu-Oreste Gostian, Benjamin Frey, Rainer Fietkau, Udo S. Gaipl, Michael Rueckert
Summary: It is found that the immune phenotype of HNSCC tumor cells is modulated by the HPV status. Although the expression of immune checkpoint molecules PD-L1, PD-L2, and HVEM significantly increased after radiochemotherapy (RCT) in HNSCC tumor cells, the expression of immune stimulatory molecule CD137 and the release of HMGB1 also significantly increased in HPV-positive cell lines, indicating an increased immunogenicity in HPV-positive tumors following RCT.
Review
Otorhinolaryngology
Mihnea Cristian Trache, Arne Boettcher, Christian Stephan Betz
Summary: This review provides practical recommendations for the screening, work-up, and management of hereditary head and neck paragangliomas based on recent molecular and empirical understanding. It highlights the high proportion of hereditary cases among head and neck paragangliomas and the importance of regular screening for new tumors in patients carrying pathological mutations. Different imaging techniques can aid in preoperative diagnosis, and radiation and active surveillance are now preferred over surgery in highly advanced cases. Complete paraganglioma removal remains the primary therapeutic goal, but preserving cranial nerve function and minimizing complications are crucial in genetically predisposed patients. An interdisciplinary approach is strongly recommended for the management of hereditary head and neck paragangliomas.
CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
(2023)