Article
Biotechnology & Applied Microbiology
Zicheng Li, Zuoheng Wang, Zhiyuan Chen, Heidi Voegeli, Judith H. Lichtman, Peter Smith, Ju Liu, Andrew T. DeWan, Josephine Hoh
Summary: This study analyzed the genetic sequences of 412 dogs from 76 breeds using whole-genome sequencing and machine learning. Multiple breed-specific genetic variations were identified, which may be related to unknown traits or disease susceptibility. These findings provide important insights for further research on genetic differences between dog breeds and their relevance to human health and disease.
Article
Genetics & Heredity
Yen On Chan, Jana Biova, Anser Mahmood, Nicholas Dietz, Kristin Bilyeu, Maria Skrabisova, Trupti Joshi
Summary: The rapid growth of sequencing technology has made whole genome re-sequencing (WGRS) data widely available, providing insights into genomic variations and their impact on phenotypic differences in plants. The GenVarX toolset, backed by various genomic and phenotypic data, allows researchers to analyze and visualize these variations, facilitating plant research. It supports easy-to-use interfaces, efficient data processing scripts, and interactive visualizations.
FRONTIERS IN GENETICS
(2023)
Article
Neurosciences
Cathal Ormond, Niamh M. Ryan, Elizabeth A. Heron, Michael Gill, William Byerley, Aiden Corvin
Summary: This study identified genes that are likely to increase the risk of schizophrenia in certain pedigrees, with the strongest evidence being for a gene involved in calcium homeostasis. Further research is needed to examine other classes of variants that may contribute to the disease burden.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2023)
Article
Cell Biology
Xingnan Zhang, Chenhao Hu, Dezhi Li, Song Liu
Summary: In this study, a primary cell line derived from a relapsed MPNST patient with NF1 was established, and NF1 and SUZ12 gene mutations were detected through sequencing. It was also found that this cell line has copy number variation on chromosome 7 and overexpression of certain genes, providing a valuable tool for the study and treatment of NF1-associated MPNST.
Article
Medicine, Legal
Junko Fujihara, Naoki Nishimoto, Toshihiro Yasuda, Haruo Takeshita
JOURNAL OF FORENSIC SCIENCES
(2019)
Article
Medicine, Legal
Junko Fujihara, Toshihiro Yasuda, Kaori Kimura-Kataoka, Haruo Takeshita
Article
Physics, Applied
Naoki Nishimoto, Junko Fujihara
INTERNATIONAL JOURNAL OF MODERN PHYSICS B
(2020)
Article
Toxicology
Junko Fujihara, Naoki Nishimoto
Summary: The study found that gallium antimonide (GaSb) can penetrate pig skin and has relatively low short-term cytotoxicity and pro-inflammatory effects on human dermal fibroblasts.
TOXICOLOGY IN VITRO
(2021)
Article
Medical Laboratory Technology
Junko Fujihara, Yoshikazu Takinami, Yasuyuki Kawai, Kaori Kimura-Kataoka, Haruo Takeshita
Summary: The study found significantly higher serum cfDNA concentrations in postmortem subjects compared to healthy controls and patients with cardiac disease, especially in those who died from asphyxia. Fragment larger than 10,000 bp was rare in postmortem samples, while a high concentration of 150-200 bp fragments was characteristic of postmortem subjects.
CLINICA CHIMICA ACTA
(2021)
Article
Medicine, Legal
Ken Inoue, Madina Apbassova, Masaharu Hoshi, Nobuo Takeichi, Yoshihiro Noso, Yoshiyuki Ohira, Dariya Shabdarbayeva, Nailya Chaizhunusova, Yersin T. Zhunussov, Junko Fujihara, Kaori Kimura-Kataoka, Yasuyuki Fujita, Haruo Takeshita
Summary: This study found that total debt may be associated with both the number of suicides and the suicide rate for both sexes, especially for males and females, over the past 40 years. On the other hand, the difference between actual income and consumer spending may only be associated with the number of suicides and the suicide rate in females. These findings suggest that factors such as debt and financial strain play a role in suicide trends, highlighting the importance of incorporating these factors into suicide prevention strategies.
Article
Physics, Applied
Junko Fujihara, Naoki Nishimoto
Summary: This study examined the toxicity of GaSb thin film on L929 cells, showing that GaSb has low toxicity in terms of cell viability, oxidative stress, inflammatory responses, apoptosis induction, and genotoxicity. GaSb did not induce apoptosis or genotoxicity, making it a desirable material for biological devices compared to arsenic-containing III-V materials.
INTERNATIONAL JOURNAL OF MODERN PHYSICS B
(2021)
Article
Materials Science, Multidisciplinary
Naoki Nishimoto, Junko Fujihara
Summary: Flexible devices have been actively studied, with Sb-based materials showing potential for medical applications. InSb and InSbN thin films were grown on PI and quartz substrates, with dilute nitride InSbN/PI exhibiting superior properties. Nitridation may play a role in substituting VSb with N and suppressing native defect formation, making dilute nitride InSbN/PI potentially useful in electronic device applications and epidermal optoelectronics.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Materials Science, Multidisciplinary
Naoki Nishimoto, Junko Fujihara
Summary: This study investigated the effects of Bi doping on InSb and InSb1 - xBix (x = 0.01, 0.02, and 0.03) thin films grown on quartz substrates and polyimide (PI) films. It was found that Bi doping improved the crystallinity and environmental stability of the films.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2022)
Article
Biochemistry & Molecular Biology
Junko Fujihara, Yoshikazu Takinami, Kaori Kimura-Kataoka, Yasuyuki Kawai, Haruo Takeshita
Summary: The source and mechanism of plasma cfDNA release in patients with myocardial infarction (MI) and other cardiac diseases were investigated in this study. The results suggest that cfDNA is mainly released by neutrophils via NETosis, especially in MI patients.
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Junko Fujihara, Naoki Nishimoto
Summary: This review summarizes the biological fate, toxicological effects, and toxicity mechanism of zinc oxide (ZnO) nanoparticles (NPs) in mammals. It is observed that ZnO NPs are mainly absorbed as Zn2+ and particles and lead to elevated Zn concentration in target organs such as the liver, kidney, lungs, and spleen. ZnO NPs induce liver damage, kidney damage, and lung injury, mainly through the generation of reactive oxygen species (ROS) and oxidative stress. Coating the surface of ZnO NPs with silica can reduce their toxicity. Due to their superior characteristics, ZnO NPs have potential biomedical applications.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Naoki Nishimoto, Junko Fujihara
Summary: The effects of dilute Bi doping on the structural properties and chemical stability of GaSb thin films were examined in this study. It was found that Bi doping improved the crystallinity of GaSb thin films, except for a concentration of 0.032, which led to abnormal growth. In addition, Bi doping suppressed the elution of highly toxic Sb under simulated physiological conditions, potentially advancing the development of flexible GaSb-based biomedical and environmental devices with improved safety and lower environmental burden.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Junko Fujihara, Naoki Nishimoto
Summary: In this study, the release of Sb species from undoped and Bi-doped InSb thin films in sodium acetate buffer was investigated using HG-MP-AES. The Sb-III concentration was measured without reduction by potassium iodide and with a lower sodium tetrahydroborate/sodium hydroxide concentration to estimate the Sb-V concentration. The results showed that Sb species were not changed by Bi doping, and a large fraction of Sb eluted as Sb-III during leaching for 28 days.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2023)
Article
Medical Laboratory Technology
Junko Fujihara, Naoki Nishimoto, Haruo Takeshita
Summary: This study aimed to investigate the concentrations and fragment distributions of plasma cfDNA in APL patients treated with ATO. The results showed that plasma cfDNA concentrations increased with ATO treatment, and the fragment distribution patterns remained consistent. Furthermore, APL-related gene mutations were successfully genotyped from plasma cfDNA. Further accumulation of data is needed to confirm whether cfDNA concentrations and fragment patterns can be used as biomarkers for APL treated with ATO.
ANNALS OF CLINICAL BIOCHEMISTRY
(2023)
Article
Chemistry, Analytical
Junko Fujihara, Naoki Nishimoto
MICROCHEMICAL JOURNAL
(2020)