Article
Immunology
Xiaonan Shen, Chunhua Zhou, Haoran Feng, Jialu Li, Tianxue Xia, Xi Cheng, Ren Zhao, Duowu Zou
Summary: The upregulation of PEA3 members ETV1 and ETV5 is associated with poor prognosis in CRC patients. ETV1 and ETV5 may play significant roles in the development of CRC, and ETV1 is specifically associated with the infiltration of cancer-associated fibroblasts and M2 macrophages in CRC. Targeting ETV1 could be a potential approach for treating CRC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Haoming Wu, Jikun Feng, Wenjing Zhong, Xiazi Zouxu, Zhengchong Xiong, Weiling Huang, Chao Zhang, Xi Wang, Jiarong Yi
Summary: Compared to other types of breast cancer, triple-negative breast cancer (TNBC) has poor prognosis due to its ineffectiveness in hormone therapy and HER2 targeted therapy. Immunotherapeutic drugs for TNBC are limited and further development is needed. This study analyzed genes co-expressed with M2 macrophages in TNBC and their influence on patient prognosis. A prognostic model was constructed and validated using different databases. The model showed good accuracy in predicting prognosis and identified potential immunotherapy drugs for TNBC treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yiming Guan, Bing Xu, Yi Sui, Hui Li, Zhezhou Chen, Yu Luan, Ruijia Yang, Wanshun Qi, Qi Guan
Summary: CYTH4 is overexpressed in glioma and associated with M2 macrophages and pyroptosis, suggesting it may serve as a potential biomarker predicting poor prognosis in glioma.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Sibo Li, Xudong Jiang, Meicun Guan, Yi Zhang, Yanfei Cao, Lina Zhang
Summary: This study investigated the expression and functions of GPX8 in glioblastoma (GBM). The results showed that GPX8 was upregulated in GBM and associated with poor prognosis. Functional studies revealed that GPX8 may promote proneural-mesenchymal transition in GBM. Additionally, the expression of GPX8 was associated with immune infiltration and the IL1/MYD88/IRAK/NF-kappa B pathway in GBM.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Ziwen Zhang, Ran Hao, Qiusheng Guo, Sheyu Zhang, Xiaojia Wang
Summary: The TP53 mutation is significantly associated with a shorter overall survival in patients with breast cancer, and is an independent predictive factor for overall survival. The TP53-mutant group exhibits higher tumor mutation burden, microsatellite instability, and tumor immune dysfunction and exclusion values for immunotherapy. In addition, TP53 mutation is related to increased ImmuneScore and StromalScore, and promotes the infiltration of Tregs, T helper cells, and M0-type macrophages in the tumor microenvironment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Lingling Lu, Huaxiang Wang, Jian Fang, Jiaolong Zheng, Bang Liu, Lei Xia, Dongliang Li
Summary: OAS1 expression is elevated in pancreatic cancer and is associated with poor prognosis, potentially linked to immune cell abundance.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ting Liu, Zhi-zhao Li, Lei Sun, Kun Yang, Jia-min Chen, Xiao-yi Han, Li-ming Qi, Xin-gang Zhou, Peng Wang
Summary: CANT1 is highly expressed in hepatocellular carcinoma (HCC) and is associated with clinical features and poor prognosis. It is involved in regulating biological processes such as cell cycle and DNA replication and is independently associated with immune cell infiltration and prognosis in HCC.
Article
Oncology
Yaojun Peng, Hongyu Liu, Qiyan Wu, Lingxiong Wang, Yanju Yu, Fan Yin, Cong Feng, Xuewen Ren, Tianyi Liu, Ling Chen, Haiyan Zhu
Summary: In this study, the potential function of ISG20, its predictive value in stratifying clinical prognosis, and its association with immunological characteristics in gliomas were comprehensively illustrated using bioinformatics. The expression pattern of ISG20 in glioma patient samples was confirmed by immunohistochemistry and immunofluorescence staining.
Article
Cell Biology
Xu Bai, Hui Chen, Brian G. Oliver
Summary: In this study, POSTN was identified as a promising biomarker for predicting the prognosis of lung cancer patients. Upregulated POSTN was found to be associated with immune cell infiltration, particularly in lung squamous cell carcinoma (LUSC). Downregulation of specific miRNAs targeted by POSTN, such as has-miR-144-3p and has-miR-30e-3p, was also linked to poor prognosis in LUSC patients.
Article
Endocrinology & Metabolism
Liying Zhu, Jun Wang, Jia'an Hu
Summary: This study found that IL4I1 expression was upregulated in thyroid cancer tissues and was associated with malignancy grade, lymph node metastasis, and extrathyroidal extension. IL4I1 was also found to be correlated with lactate, body fluid secretion, positive regulation of T cell differentiation, and cellular response to nutrients. In addition, IL4I1 promoted cancer cell proliferation, migration, and invasion. Therefore, IL4I1 may serve as a potential clinical biomarker for poor prognosis and a target for immune therapy in thyroid cancer.
BMC ENDOCRINE DISORDERS
(2023)
Article
Oncology
Xudong Ren, Yanqin Ju, Chaoqun Wang, Ran Wei, Haoting Sun, Quanbao Zhang
Summary: The study reveals that MARCKS expression on TAMs is associated with poor prognosis and immune cell infiltration in HCC.
CANCER INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Mostafa A. Darwish, Amira M. Abo-Youssef, Basim A. S. Messiha, Ali A. Abo-Saif, Mohamed S. Abdel-Bakky
Summary: This study found that CXCL16/NF-kappa B p65 signaling pathway is associated with macrophage infiltration to pancreatic islet in T1DM, and that RES successfully improved T1DM by inhibiting this pathway. The results showed significant elevation of CXCL16, NF-kappa B p65 and CD45 in islets of diabetic mice, which was later restored by RES treatment.
Article
Immunology
Yuyang Liu, Renqi Yao, Ying Shi, Yuxiao Liu, Hongyu Liu, Jialin Liu, Yunqian Guan, Yongming Yao, Ling Chen
Summary: This study comprehensively illustrated the potential function and predictive value of CD101 in patients with glioma. High levels of CD101 were associated with unfavorable clinical outcome, immune regulatory processes, and infiltration of immune cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yi Zhang, Jinchuan Li, Xiaofeng Yin
Summary: This study found that GLA expression levels in LGG are associated with immune infiltration, which may have potential value for assessing tumor development.
Article
Genetics & Heredity
Luyao Zhang, Shuang Yu, Shubin Hong, Xi Xiao, Zhihong Liao, Yanbing Li, Haipeng Xiao
Summary: The study identified BTNL9 as a potential prognostic biomarker and therapeutic target for thyroid cancer. Low BTNL9 expression was associated with poorer progression-free interval and different tumor stages, immune cell infiltrations, chemokines/cytokines in thyroid cancer.
BMC MEDICAL GENOMICS
(2023)
Article
Endocrinology & Metabolism
Yun Jeong Lee, Yeon Jin Cho, You Joung Heo, Eun-Jae Chung, Young Hun Choi, Jong-Il Kim, Young Joo Park, Choong Ho Shin, Young Ah Lee
Summary: In youth with childhood-onset Hashimoto thyroiditis (HT) in an iodine-sufficient country, the detection rate of thyroid nodules was 18.8%, with a 22.5% risk of malignancy among the detected nodules, showing increased risk in those with a family history. Additional large-scale studies are required to evaluate the usefulness of K-TIRADS or ACR-TI-RADS risk level for the differentiation of paediatric thyroid nodules.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Min Joo Kim, Ye An Kim, Sun Wook Cho, Su-jin Kim, Kyu Eun Lee, Young Joo Park, Do Joon Park, Bo Youn Cho
Summary: The study revealed a decrease in the proportion of patients undergoing ablation therapy for Graves' disease over the past 15 years, while the proportion of those undergoing surgery increased in relation to suspected thyroid cancers.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Chae Won Chung, Hoon Sung Choi, Sung Hye Kong, Young Joo Park, Do Joon Park, Hwa Young Ahn, Sun Wook Cho
Summary: The study aimed to evaluate changes in bone mineral density (BMD) and trabecular bone score (TBS) in postmenopausal DTC patients receiving TSH suppression therapy. Results showed that TBS may better reflect bone health than BMD in this patient population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Min Joo Kim, Hwan Hee Kim, Young Shin Song, Ok-Hee Kim, Kyungho Choi, Sujin Kim, Byung-Chul Oh, Young Joo Park
Summary: Following DEHP treatment, Tshr expression in rat thyroid was significantly reduced, which may contribute to thyroid dysfunction.
ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Endocrinology & Metabolism
Marcia S. Brose, Yury Panaseykin, Bhavana Konda, Christelle de la Fouchardiere, Brett G. M. Hughes, Andrew G. Gianoukakis, Young Joo Park, Ilia Romanov, Monika K. Krzyzanowska, Sophie Leboulleux, Terri A. Binder, Corina Dutcus, Ran Xie, Matthew H. Taylor
Summary: This study compared the efficacy and toxicity of lenvatinib starting at doses of 24 mg/day and 18 mg/day in patients with RR-DTC. The results showed that the objective response rate was 57.3% in the 24 mg/day arm and 40.3% in the 18 mg/day arm, indicating that the starting dose of 18 mg/day did not demonstrate noninferiority. However, there was no clinically relevant difference in the safety profile between the two arms.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biotechnology & Applied Microbiology
Diego Chowell, Seong-Keun Yoo, Cristina Valero, Alessandro Pastore, Chirag Krishna, Mark Lee, Douglas Hoen, Hongyu Shi, Daniel W. Kelly, Neal Patel, Vladimir Makarov, Xiaoxiao Ma, Lynda Vuong, Erich Y. Sabio, Kate Weiss, Fengshen Kuo, Tobias L. Lenz, Robert M. Samstein, Nadeem Riaz, Prasad S. Adusumilli, Vinod P. Balachandran, George Plitas, A. Ari Hakimi, Omar Abdel-Wahab, Alexander N. Shoushtari, Michael A. Postow, Robert J. Motzer, Marc Ladanyi, Ahmet Zehir, Michael F. Berger, Mithat Gonen, Luc G. T. Morris, Nils Weinhold, Timothy A. Chan
Summary: A machine learning model integrating genomic, molecular, demographic, and clinical data accurately predicts clinical response to immune checkpoint blockade in cancer patients. The model outperformed predictions based on tumor mutational burden and provides quantitative assessments of key model features. This approach is expected to substantially improve clinical decision-making in immunotherapy and inform future interventions.
NATURE BIOTECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Kyungsik Kim, June Young Choi, Su-jin Kim, Eun Kyung Lee, Young Ki Lee, Jun Sun Ryu, Kyu Eun Lee, Jae Hoon Moon, Young Joo Park, Sun Wook Cho, Sue K. Park
Summary: Cumulative costs of active surveillance and immediate surgery are similar in low-risk PTMC patients for 10 years, but surgery could be more economical for patients with a longer life expectancy in long-term follow-up.
Review
Oncology
Shinje Moon, Ka Hee Yi, Young Joo Park
Summary: This meta-analysis found that thyroid cancer treatment (including RAIT) does not increase the risk of adverse pregnancy outcomes for patients, and the results regarding miscarriage, preterm labor, and congenital anomalies are similar to those in the general population.
Review
Oncology
Ho-Ryun Won, Eonju Jeon, Jae Won Chang, Yea Eun Kang, Kunho Song, Sun Wook Kim, Dong Mee Lim, Tae Kwun Ha, Ki-Wook Chung, Hyo-Jeong Kim, Young Joo Park, Bon Seok Koo
Summary: There is insufficient evidence to support the effectiveness of post-operative maintenance of thyroid-stimulating hormone (TSH) levels below 2 mU/L in reducing recurrence in patients undergoing thyroid lobectomy for low-risk differentiated thyroid cancer (DTC). Further research is needed to clarify the impact of TSH maintenance in this patient population.
Article
Oncology
Seong-Keun Yoo, Diego Chowell, Cristina Valero, Luc G. T. Morris, Timothy A. Chan
Summary: This study found that high baseline serum albumin level is associated with favorable tumor radiographic response to ICB treatment. Serum albumin can be used as a biomarker in combination with tumor mutational burden to enhance predictive capacity.
NPJ PRECISION ONCOLOGY
(2022)
Letter
Medicine, General & Internal
Seong-Keun Yoo, Diego Chowell, Cristina Valero, Luc G. T. Morris, Timothy A. Chan
Letter
Endocrinology & Metabolism
Yoo Hyung Kim, Hyo-Cheol Kim, Yun Bin Lee, Samina Park, Eun-Jae Chung, Jin Chul Paeng, Young Joo Park
ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyobin Seo, Kwang Nam Jin, Ji Sang Park, Koung Mi Kang, Eun Kyung Lee, Ji Ye Lee, Roh-Eul Yoo, Young Joo Park, Ji-hoon Kim
Summary: This study evaluated the risk of thyroid cancer in a lung cancer screening population based on the presence of incidental thyroid nodules detected on low-dose chest computed tomography (LDCT). The results showed that the incidence of thyroid cancer was higher in the ITN-positive group compared to the ITN-negative group, but all cancers were papillary thyroid microcarcinomas (PTMCs). Therefore, thorough screening for thyroid incidentalomas may not be necessary in patients with a heavy smoking history.
Article
Endocrinology & Metabolism
Shinje Moon, Eun Kyung Lee, Hoonsung Choi, Sue K. Park, Young Joo Park
Summary: This study investigates the impact of ultra-sound screening on thyroid cancer outcomes. The findings suggest that early detection of thyroid cancer leads to better survival outcomes compared to symptomatic thyroid cancer.
ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Eun Kyung Lee, Yea Eun Kang, Young Joo Park, Bon Seok Koo, Ki-Wook Chung, Eu Jeong Ku, Ho-Ryun Won, Won Sang Yoo, Eonju Jeon, Se Hyun Paek, Yong Sang Lee, Dong Mee Lim, Yong Joon Suh, Ha Kyoung Park, Hyo-Jeong Kim, Bo Hyun Kim, Mijin Kim, Sun Wook Kim, Ka Hee Yi, Sue K. Park, Eun-Jae Jung, June Young Choi, Ja Seong Bae, Joon Hwa Hong, Kee-Hyun Nam, Young Ki Lee, Hyeong Won Yu, Sujeong Go, Young Mi Kang
Summary: This multicenter clinical trial aims to evaluate the efficacy and safety of TSH suppression therapy in patients with papillary thyroid cancer who have undergone lobectomy. The study focuses on outcomes such as recurrence, metabolic complications, costs, and quality of life.
ENDOCRINOLOGY AND METABOLISM
(2021)