Article
Nanoscience & Nanotechnology
Zixiang Wei, Zhicong Chao, Xindan Zhang, Jiantao Yu, Fan Xiao, Xuanjun Zhang, Leilei Tian
Summary: Mediated Fenton reaction can enhance intracellular oxidative stress through producing toxic ·OH. However, the delivery of Fe2+ in high doses to tumors and its cytotoxicity to normal tissues pose a challenge. Thus, a controllable Fe2+ delivery system has been developed to activate the Fenton reaction and enhance Fe2+ accumulation in tumors.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Struan Bourke, Federico Dona, Yurema Teijeiro Gonzalez, Basma Qazi Chaudhry, Maryna Panamarova, Eirinn Mackay, Peter S. Zammit, Lea Ann Dailey, Ulrike S. Eggert, Klaus Suhling, Mark A. Green
Summary: This study reports the encapsulation of a bright-red-emitting conjugated polymer and superparamagnetic iron oxide nanoparticles in polymer micelles. The resulting particles exhibited good emission properties and cellular uptake, making them potentially valuable for in vivo labeling applications.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Materials Science, Ceramics
Guotao Xiang, Zhen Liu, Menglin Yang, Yongxi Ding, Lu Yao, Yongjie Wang, Xianju Zhou, Li Li, Li Ma, Xiaojun Wang, Jiahua Zhang
Summary: The development of photothermal therapy (PTT) agents that can self-respond to temperature and work in deep tissues is urgently needed for noninvasive cancer treatment. In this study, a nanocomposite material called hexagonal phase NaLuF4:Yb3+/Nd3+@SiO2@Cu2S is successfully created to meet these demands. The prepared nanocrystals (NCs) exhibit excellent photothermal conversion capacity and ultrasensitive temperature sensing properties, enabling optical thermometry using the fluorescence intensity ratio of Nd3+ ions. The adsorption of Cu2S NCs on the surface of NaLuF4:Yb3+/Nd3+@SiO2 provides the necessary light-to-heat conversion capacity, making it a promising candidate for deep tissue therapy.
CERAMICS INTERNATIONAL
(2023)
Review
Chemistry, Multidisciplinary
Jing Mu, Ming Xiao, Yu Shi, Xuewen Geng, Hui Li, Yuxin Yin, Xiaoyuan Chen
Summary: Optical imaging is a non-invasive method with high resolution and sensitivity. Researchers have focused on developing contrast agents with near-infrared absorption or emission to improve imaging quality. This review summarizes recent advances in organic luminescent and photoacoustic materials and discusses their imaging performance and potential applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Optics
J. F. Silva, A. C. C. Soares, T. O. Sales, U. Rocha, W. F. Silva, C. Jacinto
Summary: This study prepared CaF2 nanoparticles doped with Yb3+ and Er3+ via co-precipitation method and explored their potential use as luminescence nanothermometers in biological systems. The results showed a linear positive dependence of the emission intensity at 660 nm with temperature and a thermal sensitivity close to 2.53% °C-1 at 26 °C. The excitation at 1064 nm was found to be more suitable to avoid light-heat conversion and tissue damage.
JOURNAL OF LUMINESCENCE
(2023)
Article
Engineering, Biomedical
Shanshan Peng, Lizhen Wang, Lin Liu, Liang Song, Junpeng Shi, Hanrun Zheng, Jixuan Xu, Rui Rong, Yun Zhang
Summary: Manipulating autophagic processes can enhance the efficacy of nanoagent-mediated photothermal therapy by inducing heat-synergistic pro-survival autophagy. This study presents a promising strategy to optimize imaging-guided photothermal therapy by modulating the autophagy induced by the nanoagent.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Walaa Mohammad, K. David Wegner, Clothilde Comby-Zerbino, Vanessa Trouillet, Marina Paris Ogayar, Jean-luc Coll, Riccardo Marin, Daniel Jaque Garcia, Ute Resch-Genger, Rodolphe Antoine, Xavier Le Guevel
Summary: In this study, ultra-small gold nanoparticles stabilized by co-ligands were synthesized, and their physicochemical properties were controlled by the amount of reducing agent used. The absorption cross-section was significantly increased by precisely controlling the reducing agent, which in turn influenced the photoluminescence quantum yield. The results suggest that the physicochemical properties of the ligand shell can be tuned to control the near-infrared absorption and photoluminescence of the gold nanoparticles.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Acoustics
Zhen Jiang, Yuanmeng Ding, Jonathan F. Lovell, Yumiao Zhang
Summary: This review summarizes NIR-II organic contrast agents reported in the past decade for photoacoustic and fluorescence imaging, and discusses the rational design of NIR-II fluorophores to improve imaging contrast and resolution. A wide variety of applications using NIR-II dyes have been realized, including imaging of tumors, lymphatics, brains, intestines, and others. Targeted imaging and activable imaging with improved resolution and sensitivity have been demonstrated by innovative chemical modification of NIR-II dyes.
Article
Chemistry, Physical
Peipei Dang, Guodong Zhang, Wei Yang, Hongzhou Lian, Guogang Li, Jun Lin
Summary: Combining rare-earth ions with halide perovskites can produce interesting optical properties in the visible and NIR regions. In this study, RE3+ ions (RE: Nd, Ho, Er, Tm) were successfully introduced into Cs4Cd1-wMnwBi2Cl12 quadruple perovskites through a hydrothermal method. The materials exhibited characteristic emission of RE3+ in the red and NIR regions via constructing a Mn2+ energy bridge. The energy transfer processes and mechanism were confirmed, and an evolution process from direct to indirect band gaps was verified.
CHEMISTRY OF MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Zhuxin Wei, Guangxin Duan, Baoxing Huang, Shanshan Qiu, Dandan Zhou, Jianfeng Zeng, Jiabin Cui, Chunhong Hu, Ximing Wang, Ling Wen, Mingyuan Gao
Summary: The study introduces a facile strategy for fabricating Nd3+-doped rare-earth core-shell nanoparticles (Nd-RENPs) with strong emission in the near-infrared-II (NIR-II) window. These Nd-RENPs can be quickly eliminated from the hepatobiliary pathway, reducing the potential risk of long-term retention in the reticuloendothelial system (RES). Additionally, the Nd-RENPs are successfully utilized for NIR-II in vivo imaging and magnetic resonance imaging (MRI) contrast agents, enabling precise detection of breast cancer.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Mengxuan Yu, Xiaohu Yang, Yejun Zhang, Hongchao Yang, Haoying Huang, Zan Wang, Jinyi Dong, Rong Zhang, Ziqiang Sun, Chunyan Li, Qiangbin Wang
Summary: A tailored route is reported for achieving controllable doping of Ag2Se QDs by exchanging Ag with Pb via cation exchange, resulting in significantly enhanced photoluminescence intensity. The Pb:Ag2Se QDs exhibit new optical features and can be successfully used for lymphatic system mapping.
Review
Chemistry, Multidisciplinary
Ke Zhang, Fu-Rong Chen, Lidai Wang, Jinlian Hu
Summary: In this review, the advantages and various imaging technologies of near-infrared-II (NIR-II) bioimaging for deep brain imaging are discussed, along with the corresponding contrast agents. The applications of NIR-II bioimaging in visualizing cerebrovascular characteristics and monitoring pathology signals, as well as its potential for modulating brain structure and function, are outlined. Future perspectives for improving the clinical translation of NIR-II light are also proposed.
Review
Chemistry, Multidisciplinary
Paige A. Shaw, Ewan Forsyth, Fizza Haseeb, Shufan Yang, Mark Bradley, Maxime Klausen
Summary: This review provides an update on available 2P instrumentation and 2P luminescent materials for optical imaging in the NIR-II window, showcasing how two-photon absorption can provide convenient access to the second biological transparency window and increase resolution capabilities.
FRONTIERS IN CHEMISTRY
(2022)
Review
Biotechnology & Applied Microbiology
Menglin Wu, Xue Li, Xiaoyu Mu, Xuening Zhang, Hao Wang, Xiao-Dong Zhang
Summary: This review provides an overview of the development of near-infrared-II (NIR-II) fluorescence imaging for studying physiological and pathological activities in living organisms. It highlights the limitations of fluorescence penetration depth and discusses the integration of NIR-II fluorescence imaging with other imaging modes to create multimodal imaging for deeper anatomical information.
Review
Chemistry, Analytical
Dong Li, Jie Pan, Shuyu Xu, Shiying Fu, Chengchao Chu, Gang Liu
Summary: Recently, activatable NIR-II fluorescent probes have shown to have specific targeting to biological tissues, providing higher imaging signal-to-background ratio and lower detection limit. Utilizing disease-associated endogenous stimuli to activate NIR-II probes is significant for achieving switchable fluorescent signals for specific deep bioimaging applications. Challenges and perspectives of activatable NIR-II fluorescent probes are also discussed in this review.
Article
Optics
Maho Takematsu, Masakazu Umezawa, Toshihiro Sera, Yuichi Kitagawa, Hiroyuki Kurahashi, Shuta Yamada, Kyohei Okubo, Masao Kamimura, Hideo Yokota, Kohei Soga
Summary: This study evaluated the influence of the difference in refractive index between the sample body and the surroundings on fluorescence CT results. It was found that refraction can cause the brightest fluorescent point to deviate from the correct point. The speculated position can be determined by immersing the body in an RI matching liquid.
Article
Chemistry, Multidisciplinary
Thi Kim Dung Doan, Masakazu Umezawa, Hisanori Kobayashi, Atsushi Oshima, Kazuno Ikeda, Kyohei Okubo, Masao Kamimura, Kohei Soga
Summary: Fluorescence imaging in the over-thousand nanometer NIR wavelength region is a new technique for real-time bioimaging. The investigation showed that the OTN-NIR probe based on DSPE-PEG micelles is unstable in albumin and PBS solutions, but remains stable in water and saline.
Article
Materials Science, Biomaterials
Thi Kim Dung Doan, Masakazu Umezawa, Kazunobu Ohnuki, Karina Nigoghossian, Kyohei Okubo, Masao Kamimura, Masayuki Yamaguchi, Hirofumi Fujii, Kohei Soga
Summary: In this study, a new bimodal OTN-NIR/MR imaging probe was designed using an OTN-NIR fluorescent organic dye and Gd-DOTA, providing high sensitivity and structural information. The probe exhibited good OTN-NIR fluorescence and MRI contrast enhancement in mouse imaging experiments. The results demonstrated the importance of the Gd-DOTA introduction ratio in controlling the biological response.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Masakazu Umezawa, Hisanori Kobayashi, Kotoe Ichihashi, Shota Sekiyama, Kyohei Okubo, Masao Kamimura, Kohei Soga
Summary: This study investigates the molecular states and optical properties of NIR-II dimer dye IR-1061 in solution and micellar nanoparticles. The dimer can dissociate into monomers in the core of micellar nanoparticles through heat treatment, resulting in enhanced NIR-II fluorescence intensity.
Article
Materials Science, Ceramics
Kohta Nambu, Taisuke Kitaoka, Koji Morita, Kohei Soga, Tomoharu Tokunaga, Takahisa Yamamoto, Hiroshi Masuda, Hidehiro Yoshida
Summary: In this study, flash joining experiments were conducted using an AC field on 3 mol% Y2O3-stabilized tetragonal ZrO2 polycrystal (Y-TZP) bodies. The necessary conditions for achieving almost complete self-joining of Y-TZP bodies were clarified. By applying an AC field at specific conditions, successful joining with 92% of the flexural strength of the as-sintered Y-TZP body was achieved.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2023)
Article
Engineering, Biomedical
Naoaki Mikami, Ikuo Yonemitsu, Hiroshi Takemura, Mark Kondou, Kouhei Soga, Kazuhiro Suga, Zuisei Kanno, WeiJen Lai, Motohiro Uo, Takashi Ono
Summary: The purpose of this study was to demonstrate the forces and moments exerted on adjacent brackets using improved superelastic Nickel-Titanium alloy wire (ISW) to close and align extraction spaces simultaneously. The results showed that the ISW generated sufficient moments with the addition of V-bends to close the space by bodily movement.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Thi Kim Dung Doan, Masakazu Umezawa, Ikeda Kazuno, Kazunobu Ohnuki, Mizuki Akatsuka, Kyohei Okubo, Masao Kamimura, Masayuki Yamaguchi, Hirofumi Fujii, Kohei Soga
Summary: We developed a small MRI/NIR-II probe for HER2 breast cancer cells. The probe contains PLGA-b-PEG micelles encapsulated with NIR-II and Gd-DOTA conjugated at the border of PLGA/PEG. Herceptin is then conjugated to carboxyl residues of PLGA-b-PEG chains. Through binding assays, we found that the optimal surface ratio of -COOH is 5% for stable probe properties and high antigen-capturing activity.
ACS APPLIED BIO MATERIALS
(2023)
Article
Engineering, Biomedical
Thi Kim Dung Doan, Masakazu Umezawa, Kyohei Okubo, Masao Kamimura, Kohei Soga
Summary: Micelles have been widely used in biomedicine as potential carriers of hydrophobic fluorescent dyes. However, their lack of stability in physiological environments limits their imaging utility. In this study, the stability of micelles was improved by introducing Gd3+ and DOTA, resulting in enhanced fluorescence intensity and stability in physiological environments.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Biochemical Research Methods
Tomohiro Mitsui, Akino Mori, Toshihiro Takamatsu, Tomohiro Kadota, Konosuke Sato, Ryodai Fukushima, Kyohei Okubo, Masakazu Umezawa, Hiroshi Takemura, Hideo Yokota, Takeshi Kuwata, Takahiro Kinoshita, Hiroaki Ikematsu, Tomonori Yano, Shin Maeda, Kohei Soga
Summary: In this study, near-infrared hyperspectral imaging was used to accurately identify the exposed and unexposed areas of gastric cancer, with a high prediction accuracy. Additionally, areas with tumor thickness greater than 2 mm were more easily identifiable.
JOURNAL OF BIOMEDICAL OPTICS
(2023)
Article
Materials Science, Ceramics
Daichi Morikawa, Kohta Nambu, Koji Morita, Hidehiro Yoshida, Kohei Soga
Summary: The impact of electric field/current on creep deformation in fine-grained 8 mol% Y2O3 stabilized cubic ZrO2 was investigated under direct and alternative current conditions. The acceleration effect caused by electric fields/currents, which cannot be explained by the increase in sample temperature due to Joule heating, is more significant in AC than in DC conditions. The deformation mechanism changes from diffusional creep to grain boundary sliding (GBS) under DC and AC, indicating that the athermal effect of electric field/current enhances GBS and its rate controlling process of cation diffusivity, especially in AC.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2023)
Article
Materials Science, Multidisciplinary
Ye Chen, Kyohei Okubo, Konstantinos Slavakis, Yoshitaka Kitamoto
Summary: This study proposes a method for estimating the distribution of magnetic nanoparticle (MNP) clusters from recorded AC magnetization spectra using an experimental-based model, and successfully applies it to biosensing.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2023)
Article
Polymer Science
Masakazu Umezawa, Hiroyuki Kurahashi, Karina Nigoghossian, Kyohei Okubo, Kohei Soga
Summary: Rare-earth-doped ceramics are NIR fluorescent materials with various potential applications. In this study, NaYF4 ceramic material with specific excitation and emission wavelengths was synthesized by controlling the doping composition of rare-earth ions. The obtained Er3+/Ho3+-doped NaYF4 particles showed long fluorescence lifetime and are expected to have wide applications in biological tissues.
JOURNAL OF PHOTOPOLYMER SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Biomaterials
Thi Kim Dung Doan, Masakazu Umezawa, Kyohei Okubo, Masao Kamimura, Masayuki Yamaguchi, Hirofumi Fujii, Kohei Soga
Summary: Multimodal imaging, combining over one-thousand-nanometer near-infrared (OTN-NIR) fluorescence and magnetic resonance (MR) imaging, is attractive for biomedical research. In this study, a bimodal OTN-NIR/MRI probe was developed by encapsulating IR-1061 in a gadolinium-tetraazacyclododecanetetraacetic acid (Gd-DOTA) conjugated poly(lactic-co-glycolic acid)-block-poly(ethylene glycol) copolymer (PLGA-b-PEG) micelle at two different locations. The probe structure with Gd-DOTA at the border of PLGA/PEG showed stable fluorescence and signal distribution, indicating enhanced structural stability and performance.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Masakazu Umezawa, Keiji Miyata, Kyohei Okubo, Kohei Soga
Summary: This study presents a computed tomography technique for mapping the temperature information in deep samples, especially biological tissues with refractive index interfaces. Using a pulsed laser and a NIR camera, the fluorescence lifetimes are visualized in three dimensions through back-projection and slope comparison method. This method provides a novel choice for observing deep tissues in biology.
APPLIED SCIENCES-BASEL
(2022)