Article
Allergy
Kathryn E. McCauley, Kaitlin Flynn, Agustin Calatroni, Vincent DiMassa, Brandon LaMere, Douglas W. Fadrosh, Kole Lynch, Michelle A. Gill, Jacqueline A. Pongracic, Gurjit K. Khurana Hershey, Carolyn M. Kercsmar, Andrew H. Liu, Christine C. Johnson, Haejin Kim, Meyer Kattan, George T. O'Connor, Leonard B. Bacharier, Stephen J. Teach, Peter J. Gergen, Lisa M. Wheatley, Alkis Togias, Petra LeBeau, Scott Presnell, Homer A. Boushey, William W. Busse, James E. Gern, Daniel J. Jackson, Matthew C. Altman, Susan Lynch
Summary: This study found that respiratory illnesses and asthma exacerbations are associated with seasonal variation in upper airway microbiota. Seasonally adjusted analysis revealed specific bacteria-host interactions that significantly increase the risk of asthma exacerbation in children.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Andrew Nishimoto, Nicholas Wohlgemuth, Jason Rosch, Stacey Schultz-Cherry, Valerie Cortez, Hannah M. Rowe
Summary: Bacterial, fungal, and helminthic species within the microbiome of mammalian hosts have significant effects on health and disease. Pathogenic viruses have evolved to interact with and potentially exploit or evade the microbiome during infection. Recent research has highlighted both synergistic and antagonistic interactions between the microbiome and pathogenic viruses, showcasing the complexity of their relationship.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Zaid Haddadin, Stockton Beveridge, Kailee Fernandez, Danielle A. Rankin, Varvara Probst, Andrew J. Spieker, Tiffanie M. Markus, Laura S. Stewart, William Schaffner, Mary Lou Lindegren, Natasha Halasa
Summary: Respiratory syncytial virus (RSV) is the leading cause of acute respiratory infections (ARIs) in hospitalized children. RSV-positive children were more likely to be hospitalized, require intensive care unit admission, and receive oxygen compared with children positive for other viruses. Higher viral load, White race, younger age, and higher severity score were independently associated with hospitalization in RSV-positive children.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Natalie Mazur, Yvette N. Lowensteyn, Joukje E. Willemsen, Christopher J. Gill, Leah Forman, Lawrence M. Mwananyanda, Dianna M. Blau, Robert F. Breiman, Shabir A. Madhi, Sana Mahtab, Emily S. Gurley, Shams El Arifeen, Nega Assefa, J. Anthony G. Scott, Dickens Onyango, Beth A. Tippet Barr, Karen L. Kotloff, Samba O. Sow, Inacio Mandomando, Ikechukwu Ogbuanu, Amara Jambai, Quique Bassat, Mauricio T. Caballero, Fernando P. Polack, Saad Omer, Abdul Momin Kazi, Eric A. F. Simoes, Ashish Satav, Louis J. Bont
Summary: The study investigated 829 RSV-related deaths in children under 1 year old from 38 developing countries, including 166 community deaths from 12 countries. It was found that infants who died in the community were younger at the time of death compared to those who died in the hospital. Neonatal deaths were also higher in the community than in hospitals.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Immunology
Ting Shi, Sophie Vennard, Francis Jasiewicz, Rory Brogden, Harish Nair
Summary: RSV-ARI in adults with comorbidities is a significant burden, with limited data available. This study estimated the incidence, hospitalization rate, and in-hospital case fatality ratio of RSV-ARI in this population, and found an association between the disease and any comorbidity.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Zifang Shang, Shuguang Tan, Dongli Ma
Summary: Respiratory syncytial virus (RSV) is a significant viral pathogen causing respiratory tract infections in infants, the elderly, and immunocompromised individuals globally. Over the past decade, there has been substantial progress in understanding the structure, function, and interactions of RSV components, as well as the host immune responses to infection. Researchers and pharmaceutical companies have shown widespread interest in searching for effective interventions for RSV infection, leading to the screening of promising monoclonal antibodies, inhibitors, and vaccine candidates.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Virology
Jessica Santiago Cruz, Luciano Kleber de Souza Luna, Vitoria Rodrigues Guimaraes Alves, Danielle Dias Conte, Nancy Cristina Junqueira Bellei
Summary: RSV plays a significant role in acute respiratory infections among children. Viral load may impact disease severity and clinical presentation. Age and coinfection with other pathogens can also influence RSV infection outcomes.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, General & Internal
E. E. Walsh, G. Perez Marc, A. M. Zareba, A. R. Falsey, Q. Jiang, M. Patton, F. P. Polack, C. Llapur, P. A. Doreski, K. Ilangovan, M. Ramet, Y. Fukushima, N. Hussen, L. J. Bont, J. Cardona, E. DeHaan, G. Castillo Villa, M. Ingilizova, D. Eiras, T. Mikati, R. N. Shah, K. Schneider, D. Cooper, K. Koury, M. -M Lino, A. S. Anderson, K. U. Jansen, K. A. Swanson, A. Gurtman, W. C. Gruber, B. Schmoele-Thoma
Summary: The RSVpreF vaccine showed efficacy in preventing RSV-associated lower respiratory tract illness and RSV-associated acute respiratory illness in adults (>= 60 years of age), with no evident safety concerns.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Critical Care Medicine
Tristan W. Clark, Kate R. Beard, Nathan J. Brendish, Ahalya K. Malachira, Samuel Mills, Cathleen Chan, Stephen Poole, Sean Ewings, Nick Cortes, Esther Nyimbili, Laura Presland
Summary: The study aimed to evaluate the impact of mPOCT on influenza detection and clinical outcomes in hospitalized patients. The results showed that the mPOCT group had a higher rate of influenza detection, more timely and appropriate antiviral treatment, and isolation facility use, which contributed to improved clinical outcomes.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Virology
Samadhan J. Jadhao, Binh Ha, Courtney McCracken, Tebeb Gebretsadik, Christian Rosas-Salazar, James Chappell, Suman Das, Tina Hartert, Larry J. Anderson
Summary: RSV infection plays a major role in respiratory tract diseases in infants and throughout life. The RSV antibody enzyme-linked immunoassay is sensitive for detecting infant infection, and the two G EIAs can indicate the group of an earlier primary infection.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, General & Internal
Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Meredith L. McMorrow, Florette Treurnicht, Nicole Wolter, Anne von Gottberg, Kathleen Kahn, Adam L. Cohen, Halima Dawood, Ebrahim Variava, Cheryl Cohen
Summary: Based on a study in South African children, the burden of RSV-associated illness was estimated, with newborns and infants being the most affected group. Implementing maternal vaccination and monoclonal antibody products for this group can help reduce the disease burden.
Review
Pharmacology & Pharmacy
Farah Elawar, Ahmed K. Oraby, Quinten Kieser, Lionel D. Jensen, Tyce Culp, Frederick G. West, David J. Marchant
Summary: RSV infection is a major cause of pediatric hospitalizations and deaths, with limited treatment options. The development of effective antivirals and vaccines is crucial in combating RSV, despite challenges in therapeutics so far. This review provides insight into current research progress and future considerations in RSV treatment.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pediatrics
Diego Rodriguez-Alvarez, Cristina Rodriguez-De Tembleque, Emilio Cendejas-Bueno, Elena Perez-Costa, Jesus Diez-Sebastian, Pedro De la Oliva
Summary: This study found that exposure to secondhand smoke increases the risk of pulmonary bacterial superinfection and the need for invasive mechanical ventilation in severely ill infants with acute bronchiolitis. Tobacco smoke significantly impacts the risk of lower respiratory tract infections in children.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
B. Kampmann, S. A. Madhi, I. Munjal, E. A. F. Simoes, B. A. Pahud, C. Llapur, J. Baker, G. Perez Marc, D. Radley, E. Shittu, J. Glanternik, H. Snaggs, J. Baber, P. Zachariah, S. L. Barnabas, M. Fausett, T. Adam, N. Perreras, M. A. Van Houten, A. Kantele, L. -M Huang, L. J. Bont, T. Otsuki, S. L. Vargas, J. Gullam, B. Tapiero, R. T. Stein, F. P. Polack, H. J. Zar, N. B. Staerke, M. Duron Padilla, P. C. Richmond, K. Koury, K. Schneider, E. V. Kalinina, D. Cooper, K. U. Jansen, A. S. Anderson, K. A. Swanson, W. C. Gruber, A. Gurtman
Summary: Vaccination of pregnant women with RSVpreF vaccine was effective in reducing severe RSV-associated lower respiratory tract illness in infants. The vaccine showed 81.8% efficacy within 90 days and 69.4% efficacy within 180 days. The vaccine was found to be safe for both mothers and infants.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Nasim Vahabi, Masoud Salehi, Julio D. Duarte, Abolfazl Mollalo, George Michailidis
Summary: The study analyzed the mortality to incidence ratio of COVID-19 in different counties in the US at different stages of the pandemic, identifying more vulnerable clusters during the three waves of the pandemic. The research found that diseases such as tuberculosis, hepatitis, and HIV/AIDS were significantly associated with more vulnerable county clusters, and heart complications and cancer were the main risk factors.
SCIENTIFIC REPORTS
(2021)
Article
Urology & Nephrology
Kathryn L. Penney, Mary K. Townsend, Constance Turman, Kimberly Glass, Kyle Staller, Peter Kraft, Francine Grodstein, Vatche A. Minassian
JOURNAL OF UROLOGY
(2020)
Article
Multidisciplinary Sciences
Paola Paci, Giulia Fiscon, Federica Conte, Valerio Licursi, Jarrett Morrow, Craig Hersh, Michael Cho, Peter Castaldi, Kimberly Glass, Edwin K. Silverman, Lorenzo Farina
SCIENTIFIC REPORTS
(2020)
Article
Clinical Neurology
Cecilia Samieri, Abhijeet Rajendra Sonawane, Sophie Lefevre-Arbogast, Catherine Helmer, Francine Grodstein, Kimberly Glass
Article
Oncology
Cheng Peng, Natalie DuPre, Trang VoPham, Yujing J. Heng, Gabrielle M. Baker, Christopher A. Rubadue, Kimberly Glass, Abhijeet Sonawane, Oana Zeleznik, Peter Kraft, Susan E. Hankinson, A. Heather Eliassen, Jaime E. Hart, Francine Laden, Rulla M. Tamimi
Article
Cell Biology
Camila M. Lopes-Ramos, Cho-Yi Chen, Marieke L. Kuijjer, Joseph N. Paulson, Abhijeet R. Sonawane, Maud Fagny, John Platig, Kimberly Glass, John Quackenbush, Dawn L. DeMeo
Review
Respiratory System
Giuditta Benincasa, Dawn L. DeMeo, Kimberly Glass, Edwin K. Silverman, Claudio Napoli
Summary: Epigenetic mechanisms, including DNA methylation and histone modifications, play important roles in pulmonary diseases like COPD, asthma, and PAH. These epigenetic marks can be detected in blood, sputum, etc., providing insights into disease pathogenesis and biomarker research for lung diseases.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Multidisciplinary Sciences
Xueming Liu, Enrico Maiorino, Arda Halu, Kimberly Glass, Rashmi B. Prasad, Joseph Loscalzo, Jianxi Gao, Amitabh Sharma
NATURE COMMUNICATIONS
(2020)
Review
Oncology
Federica Sarno, Giuditta Benincasa, Markus List, Albert-Lazlo Barabasi, Jan Baumbach, Fortunato Ciardiello, Sebastiano Filetti, Kimberly Glass, Joseph Loscalzo, Cinzia Marchese, Bradley A. Maron, Paola Paci, Paolo Parini, Enrico Petrillo, Edwin K. Silverman, Antonella Verrienti, Lucia Altucci, Claudio Napoli
Summary: Despite significant efforts in epigenetic research, clinical applications are limited and precision medicine is not widely recognized. The study of epigenetic biomarkers shows promise in clinical therapy, especially for cancer patients, and may lead to a shift towards network medicine.
CLINICAL EPIGENETICS
(2021)
Article
Genetics & Heredity
Deborah Weighill, Marouen Ben Guebila, Kimberly Glass, John Platig, Jen Jen Yeh, John Quackenbush
Summary: Profiling of whole transcriptomes has become a cornerstone of molecular biology and an invaluable tool for characterizing clinical phenotypes and identifying disease subtypes. Gene targeting scores are increasingly being used to identify disease-relevant processes and analyze differences between complex phenotypes.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Margherita De Marzio, Ayse Kilic, Enrico Maiorino, Jennifer Mitchel, Chimwemwe Mwase, Michael J. O'Sullivan, Maureen McGill, Robert Chase, Jeffrey J. Fredberg, Jin-Ah Park, Kimberly Glass, Scott T. Weiss
Summary: By conducting compression experiments on bronchial epithelial cells, the genome-wide analysis of UJT revealed different activation stages of intracellular and extracellular molecular networks induced by compression. Furthermore, the study found common genomic patterns associated with ECM remodeling in nonasthmatic and asthmatic bronchial epithelial cells.
Article
Biochemistry & Molecular Biology
Deborah Weighill, Marouen Ben Guebila, Kimberly Glass, John Quackenbush, John Platig
Summary: Understanding how individual genotypes influence gene regulation can improve our understanding of human health and development. EGRET is a method that infers genotype-specific gene regulatory networks to reveal the genetic associations driving complex phenotypes.
Article
Mathematical & Computational Biology
Abhijeet Rajendra Sonawane, Dawn L. DeMeo, John Quackenbush, Kimberly Glass
Summary: The study focuses on the application of epigenetic data in gene regulatory networks, developing the SPIDER method for network reconstruction, which shows high accuracy and cell-line-specific interactions, and has the potential to identify novel hypotheses for better characterizing cell-type and phenotype-specific regulatory mechanisms.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2021)
Article
Health Care Sciences & Services
Matthew Quinn, Arlene Chung, Kimberly Glass
Summary: This article introduces a method called ASCEPT for selecting the optimal set of changepoints in mHealth data. The method involves two stages: identifying statistically significant changepoints and trimming changepoints within linear and seasonal trends. The results show that ASCEPT outperforms other methods and has a significant impact on adjusting changepoints in downstream analysis.
Article
Genetics & Heredity
Marouen Ben Guebila, Daniel C. Morgan, Kimberly Glass, Marieke L. Kuijjer, Dawn L. DeMeo, John Quackenbush
Summary: Gene regulatory network inference allows for modeling genome-scale regulatory processes. Researchers have developed a collection of tools to model various regulatory processes and improve their performance through GPU-accelerated calculations.
NAR GENOMICS AND BIOINFORMATICS
(2022)
Article
Oncology
Jun Wang, Cheng Peng, Catherine Guranich, Yujing J. Heng, Gabrielle M. Baker, Christopher A. Rubadue, Kimberly Glass, A. Heather Eliassen, Rulla M. Tamimi, Kornelia Polyak, Susan Hankinson
Summary: This study investigated the association between early-life adiposity and breast cancer by analyzing the transcriptome of breast tumor and tumor-adjacent tissue. While no genes were found to be significantly differentially expressed based on early-life body size, pathway analysis revealed several gene sets that were either upregulated or downregulated, providing new insights into the biological and pathological mechanisms underlying the relationship between early-life adiposity and breast cancer.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2021)