Journal
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
Volume 123, Issue 9, Pages 1481-1487Publisher
WILEY-BLACKWELL
DOI: 10.1111/1471-0528.13914
Keywords
Activation; aspirin; platelet; pre-eclampsia; pregnancy; resistance
Categories
Funding
- Wellbeing of Women
- Wellbeing of Women [RTF403] Funding Source: researchfish
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Antiplatelet agents are pivotal for prevention of coronary artery disease and cerebrovascular disease worldwide. Individual patient data meta-analysis indicates that low-dose aspirin causes a 10% risk reduction in pre-eclampsia for women at high individual risk. However, in the last 15 years it has emerged that a significant proportion of aspirin-treated individuals exhibit suboptimal platelet response, determined biochemically and clinically, termed 'aspirin non-responsiveness', 'aspirin resistance' and 'aspirin treatment failure'. More recently, investigation of aspirin responsiveness has begun in pregnant women. This review explores the history and clinical relevance of 'aspirin resistance' applied to high-risk obstetric populations.
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