Journal
NUTRIENTS
Volume 11, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/nu11112706
Keywords
DASH (Dietary Approaches to Stop Hypertension); diet; nutrition; pregnancy
Categories
Funding
- European Union [696295, 289346, 613977, 733206]
- Science Foundation Ireland, Ireland [SFI/16/ERA-HDHL/3360]
- UK Biotechnology and Biological Sciences Research Council [BB/P028179/1, BB/P028187/1]
- National Centre for Research and Development [ERA-HDHL/01/ALPHABET/1/2017]
- ZonMW The Netherlands [529051014]
- ALPHABET project [696295]
- French National Agency of Research [AnrR16227KK]
- UK Medical Research Council [102215/2/13/2]
- Wellcome [102215/2/13/2]
- Foundation for medical research (FRM)
- National Agency for Research (ANR)
- National Institute for Research in Public health
- French Ministry of Health (DGS)
- French Ministry of Research
- INSERM Bone and Joint Diseases National Research (PRO-A)
- Human Nutrition National Research Programs, Paris-Sud University
- Nestle
- French National Institute for Population Health Surveillance (InVS)
- French National Institute for Health Education (INPES)
- Diabetes National Research Program (French Association of Diabetic Patients (AFD))
- ANSES
- Mutuelle Generale de l'Education Nationale a complementary health insurance (MGEN)
- French national agency for food security
- French-speaking association for the study of diabetes and metabolism (ALFEDIAM)
- Erasmus Medical Centre, Rotterdam
- Erasmus University Rotterdam
- The Netherlands Organization for Health Research and Development
- Irish Health Research Board [HRC/2007/13]
- Ministry of Science and Higher Education, Poland [PBZ-MEiN-/8/2/2006, K140/P01/2007/1.3.1.1]
- Norway through the Norwegian Financial Mechanism within the Polish-Norwegian Research Fund [PNRF-218-AI-1/07]
- National Science Centre, Poland [DEC-2014/15/B/NZ7/00998]
- Health Research Board Health Research Centre for Diet and Health Research Ireland
- National Maternity Hospital Medical Fund
- Medical Research Council
- British Heart Foundation
- Arthritis Research UK
- Food Standards Agency
- BBSRC [BB/P028179/1, BB/P028187/1] Funding Source: UKRI
- EPSRC [EP/J008192/1] Funding Source: UKRI
- MRC [G0400491, MC_U147585819, MC_UP_A620_1015, MC_UU_12011/2, MC_U147585827] Funding Source: UKRI
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The ALPHABET consortium aims to examine the interplays between maternal diet quality, epigenetics and offspring health in seven pregnancy/birth cohorts from five European countries. We aimed to use the Dietary Approaches to Stop Hypertension (DASH) score to assess diet quality, but different versions have been published. To derive a single DASH score allowing cross-country, cross-cohort and cross-period comparison and limiting data heterogeneity within the ALPHABET consortium, we harmonised food frequency questionnaire (FFQ) data collected before and during pregnancy in >= 26,500 women. Although FFQs differed strongly in length and content, we derived a consortium DASH score composed of eight food components by combining the prescriptive original DASH and the DASH described by Fung et al. Statistical issues tied to the nature of the FFQs led us to re-classify two food groups (grains and dairy products). Most DASH food components exhibited pronounced between-cohort variability, including non-full-fat dairy products (median intake ranging from 0.1 to 2.2 servings/day), sugar-sweetened beverages/sweets/added sugars (0.3-1.7 servings/day), fruits (1.1-3.1 servings/day), and vegetables (1.5-3.6 servings/day). We successfully developed a harmonized DASH score adapted to all cohorts being part of the ALPHABET consortium. This methodological work may benefit other research teams in adapting the DASH to their study's specificities.
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