Journal
NUTRIENTS
Volume 11, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/nu11102456
Keywords
breastfeeding; infant formula; bioactive compounds; visual evoked potentials; growth
Categories
Funding
- Ordesa Laboratories
- S.L. Contract University of Granada General Foundation [3349]
- SMARTFOODS (CIEN) Contract University of Granada General Foundation [4003]
- Spanish Ministry of Economy, Industry and Competitiveness
- HORIZON 2020 EU DynaHEALTH Project [633595]
- FundaciOn Carolina, Madrid, Spain
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Postnatal nutrition is essential for growth and neurodevelopment. We analyzed the influence of a new enriched-infant formula with bioactive compounds on growth, neurodevelopment, and visual function (VF) in healthy infants during their first 18 months of life. A total of 170 infants were randomized in the COGNIS randomized clinical trial (RCT) to receive a standard infant formula (SF = 85) or a new experimental infant formula supplemented with functional nutrients (EF = 85). As a control, 50 breastfed infants (BF) were enrolled. Growth patterns were evaluated up to 18 months of life; neurodevelopment was assessed by general movements at 2, 3, and 4 months; VF was measured by cortical visual evoked potentials at 3 and 12 months. No differences in growth and neurodevelopment were found between groups. Regarding VF, SF and EF infants presented prolonged latencies and lower amplitudes in the P100 wave than BF infants. In the EF group, a higher percentage of infants presented response at 71/2 ' of arc at 12 months compared to 3 months of age; a similar proportion of BF and EF infants presented responses at 71/2 ' of arc at 12 months of age. Early nutritional intervention with bioactive compounds could narrow the gap in growth and neurodevelopment between breastfed and formula-fed infants.
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