Journal
NUTRIENTS
Volume 11, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/nu11091966
Keywords
sour cherry; anthocyanins; inflammatory mediators; adipokines; obesity; type 2 diabetes; mouse
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Funding
- Ministry of National Development, Hungary [EFOP-3.6.2-16-2017-00009]
- Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, within the framework of the 4. thematic program of the University of Debrecen [20428-3/2018/FEKUTSTRAT]
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Male C57BL/6J mice were used to determine the possible therapeutic effects of our previously described tart cherry extract in a chronic obesity mouse model on metabolic parameters, glucose tolerance, inflammatory mediators, and antioxidant capacity. The control group received standard mouse chow, and the high fat control group was switched to a high fat diet and tap water supplemented with 5% sucrose. The high fat + anthocyanin group received the high fat and sucrose diet, but received the anthocyanin-rich tart cherry extract dissolved in their drinking water. After six weeks, an oral glucose tolerance test was performed, and the water-soluble antioxidant capacity (ACW), superoxide dismutase (SOD) activity, and the plasma levels of insulin, C-peptide, leptin, IL-6, MCP-1, adiponectin and resistin were measured. The high fat diet increased body weight, reduced glucose tolerance, and caused an elevation in leptin, IL-6, MCP-1, and resistin levels. Furthermore, antioxidant capacity was decreased with a significant elevation of SOD activity. Anthocyanin treatment failed to reverse the effects of the high fat diet on body weight and glucose tolerance, but significantly reduced the leptin and IL-6 levels. The tart cherry extract also made a significant enhancement in antioxidant capacity and SOD activity. Our results show that chronic anthocyanin intake has a potential to enhance redox status and alleviate inflammation associated with obesity.
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