Article
Psychiatry
Natalie C. Momen, Oleguer Plana-Ripoll, Cynthia M. Bulik, John J. McGrath, Laura M. Thornton, Zeynep Yilmaz, Liselotte Vogdrup Petersen
Summary: This study provides a comprehensive examination of the bidirectional associations between eating disorders and general medical conditions, revealing an increased comorbidity among individuals with eating disorders and vice versa. While there is some variation in comorbidity observed across different types of eating disorders, the magnitudes of relative risks do not differ greatly.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Jacopo Pruccoli, Luca Bergonzini, Angela La Tempa, Antonia Parmeggiani
Summary: There is a lack of evidence on the use of pharmacologic agents in the treatment of Anorexia Nervosa (AN), especially in childhood and adolescence. This systematic scoping review outlines the current literature evidence on the use of antipsychotics in this population. The reviewed studies suggest potential improvements in psychopathology and weight measures, although the lack of RCT or good-quality studies limits the generalizability of the findings in clinical practice.
Review
Psychology, Clinical
Katja Kurnik Mesaric, Ziga Damjanac, Tjas Debeljak, Jana Kodric
Summary: This study conducted a systematic literature review to investigate the role of psychoeducation in the treatment of eating disorders in children and adolescents. The results indicated that psychoeducation is an effective intervention, leading to weight gain, a decrease in eating disorder symptoms, and a reduction in caregiver burden. However, more randomized controlled trials are needed to determine the effectiveness of psychoeducation in the treatment of eating disorders.
EUROPEAN EATING DISORDERS REVIEW
(2023)
Article
Nutrition & Dietetics
Norbert Quadflieg, Silke Naab, Sandra Schlegl, Tabea Bauman, Ulrich Voderholzer
Summary: CBT-E involving carers is an effective intervention for adolescents with anorexia nervosa. The treatment results in significant improvements in body weight indices, drive for thinness, and other subscores of the Eating Disorder Inventory. There is also significant improvement in general psychopathology.
Review
Psychology, Clinical
Cliona Brennan, Sarah Illingworth, Erica Cini, Dee Bhakta
Summary: This review examines the relationship between weight and medical instability in adolescents with typical and atypical anorexia nervosa. It found that medical instability can occur across a range of weights, with weight loss being associated with increased medical risk. Underweight adolescents were more likely to experience lower blood pressure and bradycardia, while adolescents with a body mass index below 70% were more likely to have hypophosphatemia. Rapid weight loss was identified as an important indicator of increasing medical risk. However, more research is needed in this area.
JOURNAL OF EATING DISORDERS
(2023)
Article
Endocrinology & Metabolism
Juliane Leger, Anne Fjellestad-Paulsen, Anne Bargiacchi, Justine Pages, Didier Chevenne, Marianne Alison, Corinne Alberti, Sophie Guilmin-Crepon
Summary: By administering human growth hormone injections for 12 months, it was found that children with anorexia nervosa can significantly increase their height velocity, leading to height gain. The GH treatment group showed better performance in height growth, with a lower incidence of adverse events.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Clinical Neurology
Christina Ralph-Nearman, Brenna M. Williams, Anna Marie L. Ortiz, April R. Smith, Cheri A. Levinson
Summary: The study identified specific core symptoms and illness pathways within patients with anorexia nervosa and atypical anorexia nervosa, revealing the interconnection between sleep disturbances, anxiety, worry, and eating disorder symptoms. Symptoms related to sleep and anxiety were found to be central and strongly connected to anorexia nervosa symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Medicine, General & Internal
Leah Puckett, Daniela Grayeb, Vishnupriya Khatri, Kamila Cass, Philip Mehler
Summary: Anorexia nervosa is a complex and deadly psychiatric disorder characterized by co-occurring psychiatric diseases and physiological changes affecting various organ systems. Early recognition and treatment are crucial to prevent serious consequences for patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Psychiatry
Ruyue Zhang, Ralf Kuja-Halkola, Stina Borg, Virpi Leppae, Laura M. Thornton, Andreas Birgegard, Cynthia M. Bulik, Sarah E. Bergen
Summary: The associations between eating disorders (EDs) and schizophrenia have been recognized, and familial liability to schizophrenia in individuals with anorexia nervosa (AN) reveals distinct patterns of clinical outcomes. This study investigates the influence of schizophrenia genetic liability among individuals with EDs, finding that higher schizophrenia polygenic risk scores (PRS) are significantly associated with increased risk of major depressive disorder (MDD) and substance abuse disorder (SUD). Additionally, higher schizophrenia PRS is related to earlier age at first ED symptom, higher ED symptom scores, and increased risk of MDD and SUD.
TRANSLATIONAL PSYCHIATRY
(2023)
Review
Medicine, General & Internal
Karina W. Davidson, Michael J. Barry, Carol M. Mangione, Michael Cabana, David Chelmow, Tumaini Rucker Coker, Esa M. Davis, Katrina E. Donahue, Carlos Roberto Jaen, Martha Kubik, Li Li, Gbenga Ogedegbe, Lori Pbert, John M. Ruiz, Michael Silverstein, James Stevermer, John B. Wong
Summary: Eating disorders are psychiatric conditions that disturb eating or eating-related behaviors and impair physical and psychosocial functioning. The prevalence of these disorders is relatively high, and they are associated with various health problems. This article evaluates the benefits and harms of screening for eating disorders in adolescents and adults with a normal or high body mass index, and concludes that there is insufficient evidence to determine the balance of benefits and harms.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Psychology, Clinical
Neville H. Golden, Cynthia J. Kapphahn, Jing Cheng, Anna Kreiter, Amanda E. Downey, Erin C. Accurso, Vanessa I. Machen, Sally H. Adams, Sara M. Buckelew, Anna-Barbara Moscicki, Daniel Le Grange, Andrea K. Garber
Summary: The study compared the recovery outcomes of individuals with atypical anorexia nervosa (atypical AN) and anorexia nervosa (AN) after one year. It found that those with atypical AN had slower weight gain and remained further from their pre-illness weight. There were no significant differences in psychological recovery, resumption of menses, or rehospitalization rates between the two groups. The findings highlight the limited understanding of recovery in atypical AN and the need for new recovery assessment metrics.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2023)
Article
Psychiatry
Alexandra C. Pike, Ann L. Sharpley, Rebecca J. Park, Philip J. Cowen, Michael Browning, Erdem Pulcu
Summary: The study found that individuals who have recovered from anorexia nervosa exhibit unexpectedly higher learning rate adjustment, indicating a complex relationship between eating disorders and cognitive inflexibility.
TRANSLATIONAL PSYCHIATRY
(2023)
Review
Psychiatry
Barbara Plemeniti Tololeski, Ana Suhodolcan Grabner, Hojka Gregoric Kumperscak
Summary: This review summarizes possible ways to treat the comorbidity of ASD and anorexia nervosa in children and adolescents, emphasizing the importance of improving treatment and tailoring it specifically for young patients.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Neurosciences
E. Carretier, C. Blanchet, M. R. Moro, J. Lachal
Summary: This study aimed to systematically review strategies for treating severe depression in adolescents with anorexia nervosa. Out of 562 studies, eight were included in the final sample, with treatments including antidepressants, electroconvulsive therapy, light therapy, and nutritional treatment. More systematic studies are needed on therapeutic approaches for mood disorder comorbidities in adolescents with anorexia nervosa.
ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE
(2021)
Article
Psychiatry
Lisa-Katrin Kaufmann, Hanspeter Moergeli, Gabriella Franca Milos
Summary: The study found that low minimal lifetime BMI is associated with lower BMI at admission for adults with anorexia nervosa, while higher maximal lifetime BMI or weight suppression is related to a positive treatment outcome, even years after discharge. Maximal BMI emerged as the most important factor in predicting the weight course in adult patients with AN.
FRONTIERS IN PSYCHIATRY
(2021)