Journal
GREEN CHEMISTRY LETTERS AND REVIEWS
Volume 12, Issue 4, Pages 420-434Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17518253.2019.1687762
Keywords
Exiguobacterium aestuarii SBG4 MH185868; gold nanoparticles; response surface methodology; selenium nanoparticles
Funding
- Science and Engineering Research Board (SERB) [YSS/2015/000110]
- Department of Science and Technology [DST-PURSE-II/44/2018]
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Biogenic synthesis of bimetallic nanoparticles (gold - AuNp and selenium - SeNp) using inexpensive Tryptophan Enriched Banana Peel Media for the growth of marine isolate (Exiguobacterium aestuarii SBG4 MH185868). The response surface methodology is employed for optimizing production conditions. The surface plasmon resonance band showed lambda(max) at 540 nm (AuNp) and 284 nm (SeNp). FTIR and zeta potential analysis confirmed the stability, whereas XRD spectra revealed the nature of nanoparticles obtained at optimum conditions. SEM micrographs showed nanospheres of the following size: AuN, 30 +/- 5 nm and SeNp, 50 +/- 5 nm. Biocompatibility of Np evaluated by the hemolytic activity showed <20% hemolysis even at highest concentrations (100 mu g/ml). AuNp showed the least cytotoxicity, whereas SeNp showed considerable cytotoxicity against the breast cancer cell lines MCF - 7 and MDA-MB-231. Hence, we utilized the environment-friendly growth media for the controlled synthesis of dual Np using single bacterial strain involving feasible steps in downstream processing. [GRAPHICS] .
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