Article
Oncology
Xiaofeng Duan, Xiaobin Shang, Jie Yue, Zhao Ma, Chuangui Chen, Peng Tang, Hongjing Jiang, Zhentao Yu
Summary: A nomogram was developed to predict lymph node metastasis for patients with early-stage esophageal squamous cell carcinoma, which was validated by an independent cohort. The study confirms the accuracy of the nomogram in predicting the risk of lymph node metastasis for these patients.
Article
Oncology
Seong Yong Park, Junghee Lee, Yeong Jeong Jeon, Jong Ho Cho, Hong Kwan Kim, Yong Soo Choi, Jae Il Zo, Young Mog Shim
Summary: The presence of supraclavicular lymph node metastasis did not significantly impact the overall survival of esophageal squamous cell carcinoma patients who underwent 3-field lymph node dissection, regardless of clinical suspicion or pathologic confirmation.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Dong Tian, Kai-Yuan Jiang, Yu-Shang Yang, Hao-Ji Yan, Rui-Xuan Yu, Heng Huang, Shun-Hai Jian, Hai-Ning Zhou, Hong-Ying Wen, Long-Qi Chen
Summary: This study aimed to investigate the prognosis of lymph node metastasis (LNM) in esophageal squamous cell carcinoma (ESCC) and propose a novel N (nN) staging system. It was found that paradigestive LNM was associated with worse overall survival (OS) compared to pararespiratory LNM. The nN staging system showed superior prognostic ability than current N staging systems.
Article
Oncology
Dong-lin Li, Lin Zhang, Hao-ji Yan, Yin-bin Zheng, Xiao-guang Guo, Sheng-jie Tang, Hai-yang Hu, Hang Yan, Chao Qin, Jun Zhang, Hai-yang Guo, Hai-ning Zhou, Dong Tian
Summary: This study investigates the performance of machine learning models in predicting lymph node metastasis (LNM) in patients with T1-T2 esophageal squamous cell carcinoma (ESCC). The study finds that ML models provide good predictive value for LNM in these patients, with the naive Bayes algorithm and determination coefficient for feature selection performing the best.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Shaoyuan Zhang, Linyi Sun, Danjie Cai, Guobing Liu, Dongxian Jiang, Jun Yin, Yong Fang, Hao Wang, Yaxing Shen, Yingyong Hou, Hongcheng Shi, Lijie Tan
Summary: This study aimed to predict the lymph node status and survival of esophageal squamous cell carcinoma before treatment using PET-CT-related parameters. A total of 311 patients were included and a predictive model was constructed based on the training and test sets. The model accurately predicts the risk of lymph node metastasis and the patient's 5-year overall survival in esophageal squamous cell carcinoma.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Yu-Zhen Zheng, Xiao-Qiang Li, Jun-Ye Wang, Hong Yang, Jing Wen, Wen-Yu Zhai, Lian-Xiong Yuan, Shen-Shen Fu, Hong-Ying Liao, Jian-Hua Fu
Summary: This study suggests that a higher number of examined lymph nodes (ELNs) in patients with esophageal squamous cell carcinoma (ESCC) who underwent right transthoracic esophagectomy is associated with more accurate nodal staging and better long-term survival. The optimal ELN count threshold was found to be 21.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Xia Zhong, Xue-Hua Tu, Gu-Ha A-Lai, Ze-Guo Zhuo, Peng Yao, Ying Zhang, Zhi-Jie Xu, Yi-Dan Lin
Summary: This study found that the distance between the lower tumor margin and esophagogastric junction is associated with the risk of abdominal lymph node metastasis in patients with esophageal cancer, providing guidance for surgeons in preoperative risk assessment and lymph node dissection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Environmental Sciences
Guanqiang Ma, Xiangyan Liu, Mo Shi
Summary: This study showed that targeting MUC1 gene could downregulate DNAJB6 expression and promote tumorigenesis and metastasis in esophageal squamous cell carcinoma (ESCC) through the AKT-HSF-1 pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Oncology
Qiuyuan Huang, Suyu Li, Xiaoying Chen, Xiaohong Liu, Guangrun Zhou, Liyuan Huang, Xiaoyan Li, Kaiwu Lin, Xiangqin Zheng
Summary: The aim of this study was to construct a preoperative model predicting lymph node metastasis (LNM) in IB1-IIA2 stage cervical squamous cell cancer (CSCC) based on hematological indexes. The model demonstrated good discrimination and calibration, and can assist physicians in assessing the risk of LNM in preoperative patients.
Review
Gastroenterology & Hepatology
Kai-Yuan Jiang, Heng Huang, Wei-Yang Chen, Hao-Ji Yan, Zhen-Ting Wei, Xiao-Wen Wang, Hao-Xuan Li, Xiang-Yun Zheng, Dong Tian
Summary: Tumor size, location, macroscopic type, T1 substage, differentiation, and lymphovascular invasion are significant risk factors for lymph node metastasis in patients with T1 esophageal squamous cell carcinoma, while sex, age, and infiltrative growth pattern are not identified as such.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Songtao Zhang, Runfang Zhang, Chao Wang, Wenbo Gong, Miaomiao Xue, Lina Liu, Yuanyuan Zhang
Summary: In previously untreated oral SCC patients, Level VI metastasis is rare but associated with poor prognosis, presenting with adverse pathologic features, metastatic foci size ranging from 2.6 to 4.5 cm, high recurrence and mortality rates.
Article
Oncology
Shuang Liu, Zheng Lin, Wenqing Rao, Jing Zheng, Qianwen Xie, Yulan Lin, Xi Lin, Huilin Chen, Yuanmei Chen, Zhijian Hu
Summary: The study identified that the expression levels of serum exosomal hsa_circ_0026611 are related to lymph node metastasis in ESCC, and can serve as a prognostic predictor for ESCC patients.
Article
Oncology
Hongmei Dong, Wan Lin, Liang Du, Zhimeng Yao, Feifei Li, Shuanglong Chen, Yiteng Huang, Hongzheng Ren, Yichen Luo, Songwang Cai, Yexi Chen, Hui Tang, Xiaofu Qiu, Yunlong Pan, Xingxu Huang, Dianzheng Zhang, Shegan Gao, Sai-Ching Jim Yeung, Hao Zhang
Summary: This study demonstrates that protein tyrosine phosphatase receptor-type O (PTPRO) can suppress the metastasis of esophageal squamous cell carcinoma (ESCC). Mechanistically, PTPRO inhibits MET-mediated metastasis by dephosphorylating Y1234/1235 in the kinase activation loop of MET. PTPROlow/p-METhigh can serve as an independent prognostic factor for patients with ESCC.
Article
Oncology
Yusuke Sato, Satoru Motoyama, Yuki Wada, Akiyuki Wakita, Yuta Kawakita, Yushi Nagaki, Kaori Terata, Kazuhiro Imai, Akira Anbai, Manabu Hashimoto, Yoshihiro Minamiya
Summary: NACRT followed by esophagectomy with three-field lymph node dissection is feasible and offers the potential for long-term survival of clinical Stage III patients and even clinical Stage IVB patients with supraclavicular LN metastasis as the only distant metastatic factor. At least in patients with upper and middle thoracic ESCC, treating supraclavicular LNs as regional LNs seems to be appropriate.
Article
Cell Biology
Jian Cheng, Fang Chen, Yufeng Cheng
Summary: This study identified circadian clock genes (CCGs) associated with lymph node metastasis (LNM) in human esophageal squamous carcinoma (ESCC) and constructed a risk model based on TP53 and NAGLU that accurately predicted prognosis. The study also found differences in immune cells, immune functions, immune checkpoint molecules, and functional pathways between high- and low-risk groups.
Article
Oncology
Kirika Oyama, Mari Oba, Yoko Oshima, Hideaki Shimada
Summary: The study found that O-PNI can be used to predict short-term life expectancy in patients with end-stage gastric cancer, with O-PNI decreasing as life expectancy shortens. Different optimal cutoff values for O-PNI were identified for 8, 4, and 1 week before death.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2021)
Review
Surgery
Naoya Koda, Yoko Oshima, Keiji Koda, Hideaki Shimada
Summary: The study concluded that surgeon fatigue does not significantly affect postoperative mortality rates or total postoperative complication rates after elective surgeries, and may have minimal to no effect on postoperative mortality rates or total postoperative complication rates after non-elective surgeries.
Editorial Material
Oncology
Hideaki Shimada
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Sohei Kobayashi, Takaki Hiwasa, Takayuki Ishige, Masayuki Kano, Tyuji Hoshino, Bahityar Rahmutulla, Masanori Seimiya, Hideaki Shimada, Fumio Nomura, Hisahiro Matsubara, Kazuyuki Matsushita
Summary: This study found that the detection of anti-FIR Delta exon2 Abs in gastric cancer patients may serve as a potential biomarker for monitoring a better prognosis, with high levels of anti-FIR Delta exon2 Abs significantly associated with overall survival.
Article
Oncology
Makoto Sumazaki, Hideaki Ogata, Yoshihiro Nabeya, Akiko Kuwajima, Takaki Hiwasa, Hideaki Shimada
Summary: Tumor-associated antibodies (TAA) can be detected in cancer patients, including those with early-stage tumors. Different TAA showed varying positive rates, with non-luminal type breast cancer patients having significantly higher positivity rates. TAA may be useful for early detection of breast cancer.
Article
Oncology
Atsushi Ikeda, Satoshi Nagayama, Makoto Sumazaki, Makoto Konishi, Risa Fujii, Naomi Saichi, Satoshi Muraoka, Daisuke Saigusa, Hideaki Shimada, Yoshiharu Sakai, Koji Ueda
Summary: This study explores the proteomic information of colorectal cancer-derived TE-EVs, identifying CAT1 as a potential biomarker for colorectal cancer and emphasizing its role in tumor angiogenesis.
MOLECULAR CANCER RESEARCH
(2021)
Article
Surgery
Jin Moriyama, Yoko Oshima, Tatsuki Nanami, Takashi Suzuki, Satoshi Yajima, Fumiaki Shiratori, Kimihiko Funahashi, Hideaki Shimada
Summary: This study evaluated the clinical impact of CEA and CA19-9 values at the time of recurrence in gastric cancer patients. The results suggest that CA19-9 positive status at recurrence may have a negative prognostic impact, particularly in patients with lymph node recurrence.
Article
Gastroenterology & Hepatology
Kenji Murayama, Takashi Suzuki, Satoshi Yajima, Yoko Oshima, Tatsuki Nanami, Fumiaki Shiratori, Hideaki Shimada
Summary: This study analyzed the prognostic significance of preoperative serum creatine kinase level in patients with esophageal squamous cell carcinoma. The results showed that low serum creatine kinase level was associated with worse overall survival in male patients with esophageal squamous cell carcinoma.
Article
Oncology
Tatsuki Nanami, Isamu Hoshino, Fumiaki Shiratori, Satoshi Yajima, Yoko Oshima, Takashi Suzuki, Masaaki Ito, Takaki Hiwasa, Akiko Kuwajima, Hideaki Shimada
Summary: The study found that the levels of s-RalA-Abs and s-p53-Abs were significantly elevated in various types of cancer, with positivity rates of both antibodies above 20%. The two antibodies were complementary in prostate and breast cancers, but independent in other carcinomas.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Hideaki Shimada
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2021)
Article
Oncology
Sayaka Takagi-Maeda, Satoshi Yajima, Takashi Suzuki, Katsuaki Usami, Nobuaki Takahashi, Rinpei Niwa, Hideaki Shimada
Summary: An antibody KT112 specifically binding to cancer cells has been identified, showing potential tumor suppression effects on esophageal cancer patients due to its high cancer specificity.
Article
Surgery
Nobuto Yamazaki, Yoko Oshima, Fumiaki Shiratori, Tatsuki Nanami, Takashi Suzuki, Satoshi Yajima, Kimihiko Funahashi, Hideaki Shimada
Summary: This study evaluated the clinicopathological and prognostic significance of preoperative serum creatine kinase (CK) levels in gastric cancer. The results showed that low CK levels were predictive of poor survival in men with gastric cancer, but not in women.
Review
Oncology
Chihiro Onagi, Mari Oba, Yoko Oshima, Hideaki Shimada
Summary: The number of elderly patients undergoing gastric cancer surgery is increasing, and this study aimed to analyze the prognosis of patients aged 80 years or older. The study found that elderly patients with gastric cancer who underwent radical surgery had a 5-year survival rate of up to 57%, and postoperative complications appeared to have a minor impact.
INTERNATIONAL CANCER CONFERENCE JOURNAL
(2022)
Review
Gastroenterology & Hepatology
Hideaki Shimada, Takeo Fukagawa, Yoshio Haga, Shin-ichi Okazumi, Koji Oba
Summary: Clinical staging is crucial for advanced tumors treatment strategies. PET-CT and/or MRI are best for assessing distant metastases in gastrointestinal cancers. Different types of gastrointestinal cancers may require different diagnostic algorithms for clinical staging.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2021)
Article
Oncology
Mitsunori Ushigome, Hideaki Shimada, Yoshihiro Nabeya, Fumiaki Shiratori, Hiroaki Soda, Nobuhiro Takiguchi, Isamu Hoshino, Akiko Kuwajima, Tomoaki Kaneko, Kimihiko Funahashi
Summary: The study investigated the clinical and prognostic significance of s-RalA-Abs in patients with colorectal cancer. The presence of s-RalA-Abs was not significantly associated with clinicopathological characteristic factors, but it was found to be a useful predictor of poor relapse-free survival in patients with colorectal cancer, especially in those with a positive CEA status.
MOLECULAR AND CLINICAL ONCOLOGY
(2021)
