Article
Anesthesiology
Ming-Chun Hsieh, Cheng-Yuan Lai, Chou-Ming Yeh, Po-Sheng Yang, Jen-Kun Cheng, Hsueh-Hsiao Wang, Kuan-Hung Lin, Siao-Tong Nie, Tzer-Bin Lin, Hsien-Yu Peng
Summary: This study suggests that phosphorylated UPF1-dependent nonsense-mediated & mu;-opioid receptor mRNA decay is involved in the pathogenesis of neuropathic pain.
Article
Multidisciplinary Sciences
Georgia Katsioudi, Rene Dreos, Enes S. Arpa, Sevasti Gaspari, Angelica Liechti, Miho Sato, Christian H. Gabriel, Achim Kramer, Steven A. Brown, David Gatfield
Summary: The study demonstrates the importance of nonsense-mediated mRNA decay (NMD) in physiological control, particularly in regulating the circadian clock and gene expression.
Article
Biology
Yirong Wang, Xiaolu Tang, Jian Lu
Summary: The evolution of microRNAs in bilaterian animals has been extensively studied, with a focus on both convergent and divergent evolution. Recent evidence suggests that the miRNA pathway might have already existed in the last common ancestor of eukaryotes, and differences in animal and plant lineages arise from lineage-specific innovations and losses. The miRNA repertoire has expanded through de novo creation and duplication processes, with many newly emerged miRNAs being lineage-specific. MiRNA clustering and seed mimicry contribute to the convergent molecular evolution of miRNAs, and miRNAs from different sources can converge to degrade maternal mRNAs during animal development. MiRNAs can evolve across species due to changes in sequence, seed shifting, arm switching, and spatiotemporal expression patterns, resulting in variations in target sites among orthologous miRNAs.
BIOLOGICAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Hana Cho, Elizabeth T. Abshire, Maximilian W. Popp, Christoph Proschel, Joshua L. Schwartz, Gene W. Yeo, Lynne E. Maquat
Summary: This study identifies 13 proteins constituting the AKT signaling pathway as novel effectors of nonsense-mediated mRNA decay (NMD). The study shows that AKT supersedes UPF2 in exon-junction complexes (EJCs) and increases UPF1 helicase activity through phosphorylation, contributing to the hyperactivation of NMD in Fragile X syndrome.
Article
Plant Sciences
Jing Jin, Yuanyuan She, Ping Qiu, Wenzhong Lin, Wenwen Zhang, Jie Zhang, Zujian Wu, Zhenguo Du
Summary: Bunyaviruses, including Rice stripe virus (RSV), acquire cap structures for their mRNAs through a process called cap-snatching, which has been found to be influenced by NMD surveillance pathways in plants. The study reveals that the frequency of RSV targeting nonsense mRNAs during cap-snatching is restricted by NMD, suggesting a novel role of NMD in regulating the efficiency of cap-snatching in plant-bunyavirus interactions.
MOLECULAR PLANT PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Albert Cairo, Anna Vargova, Neha Shukla, Claudio Capitao, Pavlina Mikulkova, Sona Valuchova, Jana Pecinkova, Petra Bulankova, Karel Riha
Summary: In Arabidopsis, the transition from meiosis to mitosis is driven by translation inhibition involving processing bodies. The meiosis-specific protein TDM1 is incorporated into processing bodies through interaction with SMG7, sequestering the main translation initiation complex and inhibiting translation. Chemical inhibition of translation can overcome the failure to terminate meiosis in tdm1 mutants. TDM1-containing processing bodies down-regulate meiotic transcripts to facilitate the transition of cell fates.
Review
Biochemistry & Molecular Biology
Ling Ji, Xinyi Li, Shushu He, Song Chen
Summary: This review introduces the pathways and related microRNAs involved in osteoclastogenesis, discusses the clinical potential of targeting microRNAs for the treatment of osteoclast-mediated bone resorption, and the challenges of avoiding potential side effects and producing efficient delivery methods.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Immunology
Cen Chang, Lingxia Xu, Runrun Zhang, Yehua Jin, Ping Jiang, Kai Wei, Linshuai Xu, Yiming Shi, Jianan Zhao, Momiao Xiong, Shicheng Guo, Dongyi He
Summary: MicroRNAs (miRNAs) play crucial roles in the pathogenesis, diagnosis, and therapeutic intervention of rheumatoid arthritis (RA). They regulate gene expression, immune system differentiation, and serve as potential biomarkers and therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Evangelos D. Karousis, Oliver Muehlemann
Summary: The article reviews the important role of NMD in mRNA degradation, discusses its impact on various diseases, and proposes strategies to modulate NMD as potential therapeutic approaches.
TRENDS IN BIOCHEMICAL SCIENCES
(2022)
Review
Neurosciences
Karolina Anna Kolosowska, Gerhard Schratt, Jochen Winterer
Summary: Information processing in neuronal circuits relies on proper development and interplay between principal and inhibitory interneurons. miRNA-dependent gene regulation plays a crucial role in the development and function of inhibitory interneurons, affecting their migration, maturation, survival, and cognitive function. Dysregulation of miRNAs in GABAergic interneurons may contribute to neurodevelopmental and neuropsychiatric disorders.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Immunology
Sara Assadiasl, Misagh Rajabinejad, Narjes Soleimanifar, Farideh Makiyan, Esfandiar Azizi, Alireza Rezaiemanesh, Mohammad Hossein Nicknam
Summary: Rheumatoid arthritis and ankylosing spondylitis are two common rheumatic disorders characterized by persistent inflammatory joint disease. This review provides an overview of the most important signaling pathways controlled by miRNAs in these diseases.
INFLAMMOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Milad Ashrafizadeh, Ali Zarrabi, Sima Orouei, Kiavash Hushmandi, Azadeh Hakimi, Amirhossein Zabolian, Salman Daneshi, Saeed Samarghandian, Behzad Baradaran, Masoud Najafi
Summary: This article discusses the impact of chemoresistance on cancer treatment, emphasizing the importance of autophagy and miRs in cancer cells, as well as their roles in cancer chemotherapy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biology
Yukio Kurihara, Yuko Makita, Masaharu Kawauchi, Ami Kageyama, Tomoko Kuriyama, Minami Matsui
Summary: Recent evidence suggests the existence of readthrough transcripts (RTs), including polycistronic mRNAs, in eukaryotes. This study identifies 271 loci producing polycistronic RTs in Arabidopsis. The accumulation of RTs is increased in NMD-deficient mutants compared to the wild type. Additionally, the translation of the second open reading frames (ORFs) of bicistronic mRNAs is rare. Intergenic splicing (IS) events occur in 158 RTs, and inhibiting splicing promotes the accumulation of RTs.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Salvatore Pulcrano, Roberto De Gregorio, Claudia De Sanctis, Laura Lahti, Carla Perrone-Capano, Donatella Ponti, Umberto di Porzio, Thomas Perlmann, Massimiliano Caiazzo, Floriana Volpicelli, Gian Carlo Bellenchi
Summary: The development of midbrain dopaminergic neurons requires precise regulation of a specific gene expression program, which is controlled by the Lmx1a-miR-204/211-Nurr1 axis. The miR-204/211 acts as a molecular switch to regulate the timing of Nurr1 expression, ultimately leading to the differentiation of mature midbrain dopaminergic neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Miaoran Xia, Bingbing Wang, Zihan Wang, Xulong Zhang, Xi Wang
Summary: NK cells are a heterogeneous and plastic population that can directly kill target cells without prior immunization, with their activation controlled by the balance of multiple germline-encoded activating and inhibitory receptors. Epigenetic regulation plays an important role in NK cell-mediated antitumor immunity, and NK cell-based immunotherapy is considered a promising strategy for cancer treatment. By targeting intrinsic epigenetic regulators alone or in combination with other strategies, there is potential to enhance NK cell-mediated antitumor cytotoxicity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemical Research Methods
Seo-Won Choi, Hyun-Woo Kim, Jin-Wu Nam
BRIEFINGS IN BIOINFORMATICS
(2019)
Article
Biochemistry & Molecular Biology
Hyeon J. Lee, Ramu Gopalappa, Hongjae Sunwoo, Seo-Won Choi, Suresh Ramakrishna, Jeannie T. Lee, Hyongbum H. Kim, Jin-Wu Nam
NUCLEIC ACIDS RESEARCH
(2019)
Article
Oncology
Sang-Ho Yoon, Seo-Won Choi, Suk Woo Nam, Kyoung Bun Lee, Jin-Wu Nam
Summary: The study explores the immune landscapes in premalignant and early HCC stages, highlighting that total hepatectomy patients have elevated immune infiltration and prolonged disease-free survival. However, patients with regulatory T cell infiltration pretransplantation have a higher risk of tumor relapse. The infiltration of Tregs appears to be independent of molecular classifications based on transcriptomic data.
NPJ PRECISION ONCOLOGY
(2021)
Article
Biology
Hyun Young Kim, Young Jae Choi, Sang Kyum Kim, Hyunsung Kim, Dae Won Jun, Kyungrok Yoon, Nayoun Kim, Jungwook Hwang, Young-Mi Kim, Sung Chul Lim, Keon Wook Kang
Summary: This study conducted in mouse models of liver fibrosis revealed that auranofin exerts its therapeutic effects by inhibiting the NLRP3 inflammasome via the system Xc pathway in bone marrow-derived macrophages and kupffer cells. This inhibition was shown to reduce migration of hepatic stellate cells, providing a potential new approach for treating liver fibrosis.
COMMUNICATIONS BIOLOGY
(2021)
Review
Biochemical Research Methods
Eun-Gyeong Park, Sung-Jin Pyo, Youxi Cui, Sang-Ho Yoon, Jin-Wu Nam
Summary: This review discusses the specific expression of long non-coding ribonucleic acids (lncRNAs) in tumor and immune cells, summarizes their regulatory functions at the cell type level, and highlights the application of single-cell RNA-sequencing (scRNA-seq) in studying the cell type-specific functions of lncRNAs in the tumor immune microenvironment (TIME).
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Biochemistry & Molecular Biology
Suman Lee, Yukyung Hwang, Tae Hun Kim, Jaemin Jeong, Dongho Choi, Jungwook Hwang
Summary: This study highlights the tumor-suppressive function of UPF1 in the growth of human hepatocellular carcinoma (HCC), which inhibits cell growth by regulating the level of DUSP1.
Article
Gastroenterology & Hepatology
Ju Hee Oh, Dae Won Jun, Hye Young Kim, Seung Min Lee, Eileen L. Yoon, Jungwook Hwang, Jung Hwan Park, Hanbi Lee, Wankyu Kim, Hyunsung Kim
Summary: This study aimed to identify an optimal target population and drug-specific biomarkers that can predict dipeptidyl peptidase (DPP)-4 inhibitor responses in non-alcoholic fatty liver disease (NAFLD). The study found that DPP-4 inhibitors attenuated NAFLD activity score and fibrosis stage in the high-fat diet (HFD) model. Additionally, hepatic or serum levels of Igfbp-1 were associated with DPP-4 inhibitor response.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Seong-geun Moon, Ansun Jeong, Yunji Han, Jin-Wu Nam, Mi Kyung Kim, Inah Kim, Yu-Mi Kim, Boyoung Park
Summary: This study aims to investigate the health status and hereditary effects of atomic bomb exposure on the offspring of atomic bomb survivors. Through cohort studies and whole-genome analysis of survivors and their offspring, the study will elucidate the hereditary health effects of atomic bomb exposure.
JOURNAL OF PREVENTIVE MEDICINE & PUBLIC HEALTH
(2023)
Article
Chemistry, Medicinal
Gi-Ae Kim, Hyun Chin Cho, Soung Won Jeong, Bo-Kyeong Kang, Mimi Kim, Seungwon Jung, Jungwook Hwang, Eileen L. Yoon, Dae Won Jun
Summary: Preclinical data have shown that ALS-L1023, an herbal extract from Melissa officinalis, can reduce visceral fat and hepatic steatosis. In this study, we evaluated the safety and efficacy of ALS-L1023 as a treatment for non-alcoholic fatty liver disease (NAFLD). The results showed that ALS-L1023 could significantly reduce hepatic fat content and improve liver stiffness in patients with NAFLD, with no significant differences in adverse events among the study groups.
Review
Biochemical Research Methods
Dohun Yi, Jin-Wu Nam, Hyobin Jeong
Summary: Structural variants (SVs) are diverse genomic rearrangements that accumulate in the genome during cell development and aging, potentially impacting cancer development. Detecting somatic SVs is challenging but crucial for understanding their functional implications. This review summarizes recent advances in whole-genome sequencing (WGS)-based approaches for somatic SV detection, including computational algorithms for bulk WGS data and cutting-edge single-cell techniques. The advantages and limitations of bulk and single-cell approaches are discussed, along with their potential for linking somatic SVs to functional readouts.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Medicine, General & Internal
Ansun Jeong, Seong-geun Moon, Yunji Han, Jin-Wu Nam, Mi Kyung Kim, Inah Kim, Yu-Mi Kim, Boyoung Park
Summary: This study aimed to compare the cause of death between atomic bomb survivors and the general population, and found a higher proportional mortality of respiratory and nervous system diseases among atomic bomb survivors.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Seokju Park, Hee Doo Yang, Jwa-Won Seo, Jin-Wu Nam, Suk Woo Nam
Summary: This article discusses how the editing of microRNAs can lead to the production of isomiRs, which can alter gene regulation networks and contribute to the development of liver cancer. The study also identifies two specific isomiRs associated with liver cancer and highlights their role in suppressing the growth hormone receptor. The results suggest that targeting these isomiRs could be a potential strategy for developing new treatments for liver cancer.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
