Cryo-EM structures of lipopolysaccharide transporter LptB2FGC in lipopolysaccharide or AMP-PNP-bound states reveal its transport mechanism

Structural basis of unidirectional export of lipopolysaccharide to the cell surface

(2019) Tristan W. Owens et al.   NATURE

Structural basis of lipopolysaccharide extraction by the LptB2FGC complex

(2019) Yanyan Li et al.   NATURE

Novobiocin Enhances Polymyxin Activity by Stimulating Lipopolysaccharide Transport

(2018) Michael D. Mandler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A cluster of residues in the lipopolysaccharide exporter that selects substrate variants for transport to the outer membrane

(2018) Blake R. Bertani et al.   MOLECULAR MICROBIOLOGY

Lipopolysaccharide is transported to the cell surface by a membrane-to-membrane protein bridge

(2018) David J. Sherman et al.   SCIENCE

Outer Membrane Translocon Communicates with Inner Membrane ATPase To Stop Lipopolysaccharide Transport

(2018) Ran Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thanatin targets the intermembrane protein complex required for lipopolysaccharide transport in Escherichia coli

(2018) Stefan U. Vetterli et al.   Science Advances

The Antibiotic Novobiocin Binds and Activates the ATPase That Powers Lipopolysaccharide Transport

(2017) Janine M. May et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Structural basis for lipopolysaccharide extraction by ABC transporter LptB2FG

(2017) Qingshan Luo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural and functional insights into the lipopolysaccharide ABC transporter LptB2FG

(2017) Haohao Dong et al.   Nature Communications

Structural basis for lipopolysaccharide extraction by ABC transporter LptB2FG

(2017) Qingshan Luo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Structural and Functional Characterization of the LPS Transporter LptDE from Gram-Negative Pathogens

(2016) Istvan Botos et al.   STRUCTURE

Lipopolysaccharide Transport to the Cell Surface: New Insights in Assembly into the Outer Membrane

(2016) Paola Sperandeo et al.   STRUCTURE

Identification of Residues in the Lipopolysaccharide ABC Transporter That Coordinate ATPase Activity with Extractor Function

(2016) Brent W. Simpson et al.   mBio

Semi-automated selection of cryo-EM particles in RELION-1.3

(2015) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Lipopolysaccharide transport to the cell surface: periplasmic transport and assembly into the outer membrane

(2015) Janine M. May et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Lipopolysaccharide is Inserted into the Outer Membrane through An Intramembrane Hole, A Lumen Gate, and the Lateral Opening of LptD

(2015) Yinghong Gu et al.   STRUCTURE

Trapped lipopolysaccharide and LptD intermediates reveal lipopolysaccharide translocation steps across the Escherichia coli outer membrane

(2015) Xuejun Li et al.   Scientific Reports

Biosynthesis and Export of Bacterial Lipopolysaccharides

(2014) Chris Whitfield et al.   Annual Review of Biochemistry

Structural and functional studies of conserved nucleotide-binding protein LptB in lipopolysaccharide transport

(2014) Zhongshan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Cross-Disciplinary Perspective on the Innate Immune Responses to Bacterial Lipopolysaccharide

(2014) Yunhao Tan et al.   MOLECULAR CELL

Lipopolysaccharide rolls out the barrel

(2014) Russell E. Bishop   NATURE

Structural basis for outer membrane lipopolysaccharide insertion

(2014) Haohao Dong et al.   NATURE

Structural basis for lipopolysaccharide insertion in the bacterial outer membrane

(2014) Shuai Qiao et al.   NATURE

LptE binds to and alters the physical state of LPS to catalyze its assembly at the cell surface

(2014) Goran Malojčić et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport

(2014) David J. Sherman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Escherichia coli Lpt Transenvelope Protein Complex for Lipopolysaccharide Export Is Assembled via Conserved Structurally Homologous Domains

(2013) R. Villa et al.   JOURNAL OF BACTERIOLOGY

Disruption of LptA oligomerization and affinity of the LptA-LptC interaction

(2013) Kathryn M. Schultz et al.   PROTEIN SCIENCE

Regulated Assembly of the Transenvelope Protein Complex Required for Lipopolysaccharide Export

(2012) Elizaveta Freinkman et al.   BIOCHEMISTRY

Cytoplasmic ATP Hydrolysis Powers Transport of Lipopolysaccharide Across the Periplasm in E. coli

(2012) S. Okuda et al.   SCIENCE

Characterization of interactions between LPS transport proteins of the Lpt system

(2011) Alexandra Bowyer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

New Insights into the Lpt Machinery for Lipopolysaccharide Transport to the Cell Surface: LptA-LptC Interaction and LptA Stability as Sensors of a Properly Assembled Transenvelope Complex

(2010) P. Sperandeo et al.   JOURNAL OF BACTERIOLOGY

Structure and Functional Analysis of LptC, a Conserved Membrane Protein Involved in the Lipopolysaccharide Export Pathway inEscherichia coli

(2010) An X. Tran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonconsecutive disulfide bond formation in an essential integral outer membrane protein

(2010) N. Ruiz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

(2010) N. Srinivas et al.   SCIENCE

The Bacterial Cell Envelope

(2010) T. J. Silhavy et al.   Cold Spring Harbor Perspectives in Biology

The lipopolysaccharide transport system of Gram-negative bacteria

(2009) Paola Sperandeo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol

(2009) Huanting Liu et al.   BMC BIOTECHNOLOGY

Biochemical characterization of an ABC transporter LptBFGC complex required for the outer membrane sorting of lipopolysaccharides

(2009) Shin-ichiro Narita et al.   FEBS LETTERS

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

The molecular basis of the host response to lipopolysaccharide

(2009) Clare E. Bryant et al.   NATURE REVIEWS MICROBIOLOGY

Novel Structure of the Conserved Gram-Negative Lipopolysaccharide Transport Protein A and Mutagenesis Analysis

(2008) Michael D.L. Suits et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli

(2008) N. Ruiz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA