Journal
EPIGENOMICS
Volume 11, Issue 15, Pages 1733-1748Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2019-0119
Keywords
apoptosis; autophagy; lncRNA-miRNA-mRNA axes; myocardial ischemia; necrosis; reperfusion injury
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Funding
- National Natural Science Foundation of China [81860050, 81460044, 81160035]
- Yunnan Provincial Science and Technology Department [2017FE468[-039]]
- Health Commission of Yunnan Province [2018NS0126]
- Program for Innovative Research Team of Kunming Medical University [CXTD201802]
- Yunnan Provincial Ten Thousand-Talent Program-Famous Doctor
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Emerging evidence has demonstrated that regulatory noncoding RNAs (ncRNAs), such as long noncoding RNAs (lncRNAs) and miRNAs, play crucial roles in the initiation and progress of myocardial ischemia-reperfusion injury (MIRI), which is associated with autophagy, apoptosis and necrosis of cardiomyocytes, as well as oxidative stress, inflammation and mitochondrial dysfunction. LncRNAs serve as a precursor or host of miRNAs and directly/indirectly affecting miRNAs via competitive binding or sponge effects. Simultaneously, miRNAs post-transcriptionally regulate the expression of genes by targeting various mRNA sequences due to their imperfect pairing with mRNAs. This review summarizes the potential regulatory role of lncRNA-miRNA-mRNA axes in MIRI and related molecular mechanisms of cardiac disorders, also provides insight into the potential therapies for MIRI-induced diseases.
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