Article
Agriculture, Dairy & Animal Science
Junliang Li, Weina Chen, Dongjie Li, Shukai Gu, Xiaoqian Liu, Yanqiu Dong, Lanjie Jin, Cui Zhang, Shijie Li
Summary: Genomic imprinting plays a crucial role in mammalian development, with specific genes being paternally or maternally expressed based on DNA methylation. Comparing imprinted genes across species can provide insights into the biological significance and regulatory mechanisms of genomic imprinting. MKRN3, MAGEL2, and NDN are paternally imprinted genes identified in the human PWS/AS locus, and their expression in bovine tissues suggests conserved monoallelic expression patterns between species.
Review
Cell Biology
Courtney W. Hanna, Gavin Kelsey
Summary: Genomic imprinting refers to the monoallelic expression of a gene based on parent of origin, which is a result of differential epigenetic marking between male and female germlines. Apart from the canonical DNA methylation-mediated imprinting, there is also non-canonical imprinting caused by maternal H3K27me3-independent of DNA methylation. Conservation of canonical and noncanonical genomic imprinting and the role of endogenous retroviral elements are discussed in this review.
GENES & DEVELOPMENT
(2021)
Article
Cell Biology
Teruhito Ishihara, Oliver W. Griffith, Shunsuke Suzuki, Marilyn B. Renfree
Summary: This study reveals that the active histone-3 lysine-4 trimethylation (H3K4me3) marks in the paternal genome remain present in sperm and embryos, playing a role in the regulation of parent-of-origin-specific gene expression from early zygotic stages to implantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Junliang Li, Dawei Yu, Jing Wang, Chongyang Li, Qingwei Wang, Weihua Du, Shanjiang Zhao, Yunwei Pang, Haisheng Hao, Xueming Zhao, Huabin Zhu, Shijie Li, Huiying Zou
Summary: This study investigates the imprinting status and methylation regulation of the DLK1-DIO3 region in wild-type and cloned neonatal pigs. The results reveal the abnormal imprinting and hypermethylation in the DLK1-DIO3 region in cloned pigs, providing a theoretical basis for improving cloning efficiency by gene editing to correct abnormal imprinting.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Hisato Kobayashi
Summary: Genomic imprinting is an epigenetic phenomenon that leads to unequal expression of homologous maternal and paternal alleles in the mouse genome. More than 260 imprinted genes have been identified, most of which are controlled by imprinted germline differentially methylated regions, while a subset of genes are controlled by maternal-derived histone modifications. Understanding DNA methylation-dependent and -independent imprints may provide new insights into genetic regulation and evolutionary divergence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Hisato Kobayashi
Summary: Genomic imprinting is an epigenetic phenomenon that results in unequal expression of homologous maternal and paternal alleles. This process can maintain parental epigenetic memories following fertilization and induce allele-specific transcription and chromatin modifications of neighboring genes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Genetics & Heredity
Rujuan Dai, Zhuang Wang, S. Ansar Ahmed
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting multiple organs, with DNA methylation and miRNAs playing key roles in its pathogenesis. The interaction between DNA methylation and miRNAs regulation impacts the expression of lupus-related miRNAs and DNA methylation status.
Article
Biochemistry & Molecular Biology
Dereje D. Jima, David A. Skaar, Antonio Planchart, Alison Motsinger-Reif, Sebnem E. Cevik, Sarah S. Park, Michael Cowley, Fred Wright, John House, Andy Liu, Randy L. Jirtle, Cathrine Hoyo
Summary: This study identified potential imprint control regions (ICRs) in the human genome using whole-genome bisulphite sequencing. The researchers found that the methylation patterns of these regions are similar across different cell types and are located in known binding sites and hypersensitive regions. This research is of great importance for studying the mechanisms underlying human diseases and developmental and behavioral disorders.
Article
Genetics & Heredity
Alana C. Jones, Amit Patki, Steven A. Claas, Hemant K. Tiwari, Ninad S. Chaudhary, Devin M. Absher, Leslie A. Lange, Ethan M. Lange, Wei Zhao, Scott M. Ratliff, Sharon L. R. Kardia, Jennifer A. Smith, Marguerite R. Irvin, Donna K. Arnett
Summary: Left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular disease, and African Americans have a higher risk of LVH. This study used methylation and echocardiography data to identify differentially methylated regions (DMRs) associated with LVH in African Americans. The results suggest potential candidate genes and variants related to LVH and highlight the importance of DNA methylation patterns in the development of LVH.
Article
Multidisciplinary Sciences
Zhenhui Zhong, Suhua Feng, Sascha H. Duttke, Magdalena E. Potok, Yiwei Zhang, Javier Gallego-Bartolom, Wanlu Liu, Steven E. Jacobsen
Summary: DNA methylation influences chromatin accessibility, particularly in heterochromatin, in plants. Different sequence contexts of DNA methylation interact with each other, and methylation can impact chromatin structure through mechanisms other than transcription. Increased chromatin accessibility is associated with enhanced long-range chromatin interactions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Genetics & Heredity
Zahra Anvar, Imen Chakchouk, Hannah Demond, Momal Sharif, Gavin Kelsey, Ignatia B. Van den Veyver
Summary: Genomic imprinting is an epigenetic process affecting development, with multi-locus imprinting disturbances possibly leading to disorders. Pathogenic gene variants can cause rare embryonic and reproductive issues.
Article
Oncology
Leila Cabral de Almeida Cardoso, Alejandro Parra, Cristina Rios Gil, Pedro Arias, Natalia Gallego, Valeria Romanelli, Piranit Nik Kantaputra, Leonardo Lima, Juan Clinton Llerena Junior, Claudia Arberas, Encarna Guillen-Navarro, Julian Nevado, Jair Tenorio-Castano, Pablo Lapunzina
Summary: Beckwith-Wiedemann syndrome spectrum (BWSp) is an overgrowth disorder caused by imprinting or genetic alterations at the 11p15.5 locus. Clinical features include overgrowth, macroglossia, neonatal hypoglycaemia, omphalocele, hemihyperplasia, cleft palate, and increased neoplasm incidence. This study examined the clinical and molecular features of all cases of BWSp with CDKN1C variants identified by the Spanish Overgrowth Registry Initiative, with a focus on tumor development in CDKN1C-associated BWSp. The study found that tumor development in patients with BWSp and CDKN1C variants is infrequent but relevant to patient follow-up, supporting the high heterogeneity of BWSp clinical features associated with CDKN1C variants.
Article
Cell Biology
Shaili Regmi, Lana Giha, Ahado Ali, Christine Siebels-Lindquist, Tamara L. L. Davis
Summary: Differential methylation of imprinting control regions is essential for parental allele distinction and regulation of gene expression. DNA methyltransferase 1 plays a crucial role in maintaining the inherited methylation patterns, but little is known about how imprinting control regions direct the acquisition and maintenance of methylation at secondary sites. Recent analysis suggests that DNA methyltransferase 1 may function differently at different loci, and our study shows that it specifically maintains methylation at imprinting control regions but not at corresponding secondary differentially methylated regions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Nutrition & Dietetics
Aatish Mahajan, Divika Sapehia, Beenish Rahat, Jyotdeep Kaur
Summary: Maternal folic acid and B-12 status during pregnancy influence fetal growth. This study reveals that altered dietary ratio of folic acid and B-12 affects the regulation of the H19/IGF2 locus in mice.
BRITISH JOURNAL OF NUTRITION
(2022)
Review
Plant Sciences
Hikaru Sato, Claudia Koehler
Summary: Seed dormancy is an important adaptive trait that allows plant seeds to germinate at the right environmental conditions for survival. The endosperm, a reproductive tissue formed after fertilization, plays a crucial role in establishing seed dormancy. Recent studies have shown that imprinted genes are involved in this process, revealing a new mechanism of parental control over this adaptive trait.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jeremy D. Grevet, Xianjiang Lan, Nicole Hamagami, Christopher R. Edwards, Laavanya Sankaranarayanan, Xinjun Ji, Saurabh K. Bhardwaj, Carolyne J. Face, David F. Posocco, Osheiza Abdulmalik, Cheryl A. Keller, Belinda Giardine, Simone Sidoli, Ben A. Garcia, Stella T. Chou, Stephen A. Liebhaber, Ross C. Hardison, Junwei Shi, Gerd A. Blobel
Article
Multidisciplinary Sciences
Vivek Behera, Perry Evans, Carolyne J. Face, Nicole Hamagami, Laavanya Sankaranarayanan, Cheryl A. Keller, Belinda Giardine, Kai Tan, Ross C. Hardison, Junwei Shi, Gerd A. Blobel
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Caroline R. Bartman, Nicole Hamagami, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Gerd A. Blobel, Arjun Raj
Article
Cell Biology
Vivek Behera, Aaron J. Stonestrom, Nicole Hamagami, Chris C. Hsiung, Cheryl A. Keller, Belinda Giardine, Simone Sidoli, Zuo-Fei Yuan, Natarajan Bhanu, Michael T. Werner, Hongxin Wang, Benjamin A. Garcia, Ross C. Hardison, Gerd A. Blobel
Article
Biochemistry & Molecular Biology
Michael T. Werner, Hongxin Wang, Nicole Hamagami, Sarah C. Hsu, Jennifer A. Yano, Aaron J. Stonestrom, Vivek Behera, Yichen Zong, Joel P. Mackay, Gerd A. Blobel
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Political Science
Carol Hager, Nicole Hamagami
REVIEW OF POLICY RESEARCH
(2020)