Article
Oncology
Yi-Rong Gan, Ling Wei, Yan-Zhen Wang, Zong-Ke Kou, Tian-Xiang Liang, Guan-Waner Ding, Yan-Hong Ding, Ding-Xiong Xie
Summary: This study found that knockdown of CCN1 can alleviate PA-induced inflammation and apoptosis of endothelial cells by inhibiting activation of the Wnt/beta-catenin signaling pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Qing-Yun Xie, Lu-Ping Huang, Feng-Wei Gao, Da-Qing Liu, Xia Wang, Kang-Yi Jiang, Jie Gong, Xin Zhao, Ben-Jian Gao, Ze-Hua Lei
Summary: This study investigated the therapeutic efficacy of lenvatinib combined with sequential TACE on primary HCC and its effects on serum bFGF and VEGF. The results showed that the combination treatment group had a higher objective response rate, lower serum bFGF and VEGF levels, and better survival rates.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Agnese Montanino, Anna Manzo, Guido Carillio, Giuliano Palumbo, Giovanna Esposito, Vincenzo Sforza, Raffaele Costanzo, Claudia Sandomenico, Gerardo Botti, Maria C. Piccirillo, Priscilla Cascetta, Giacomo Pascarella, Carmine La Manna, Nicola Normanno, Alessandro Morabito
Summary: Inhibition of angiogenesis has shown efficacy in treating SCLC, with anlotinib being the only drug that has demonstrated improvement in both overall survival (OS) and progression-free survival (PFS) in Chinese patients. Future challenges include evaluating angiogenesis inhibitors in combination with immune-checkpoint inhibitors and chemotherapy in SCLC patients, as well as identifying predictive biomarkers of response to these agents.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xinlong Xie, Qiying Wu, Yuhong Liu, Chunyang Chen, Zeguo Chen, Chao Xie, Mingzhe Song, Zhenlin Jiang, Xiaoke Qi, Sixi Liu, Zhenjie Tang, Zhongshi Wu
Summary: This study evaluated the effect of VEGF on neointimal hyperplasia and local inflammatory responses in decellularized small-diameter vascular grafts. The results showed that local administration of VEGF attenuated neointimal hyperplasia by inducing macrophage M2 polarization and modulating the inflammatory response.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Oncology
Tomoyuki Naito, Yuji Minegishi, Hideaki Shiraishi, Tatsuhiko Hoshino, Junichi Maeda, Toshiya Yokota, Shingo Ikeda, Miyanaga Akihiko, Masahiro Seike
Summary: The study explores the impact of background cardiovascular risk factors on VEGF inhibitor-related adverse vascular events (AVEs) in NSCLC patients. It found that male gender, smoking history, hypertension, dyslipidemia, diabetes, and cardiovascular disease were associated with increased risk of VEGF-related AVEs. Hypertension and chronic kidney disease were associated with discontinuation due to VEGF-related AVEs. The study recommends caution in using VEGF inhibitors for patients with ≥3 cardiovascular risk factors.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Kenji Nakahama, Hiroyasu Kaneda, Masahiko Osawa, Mitsuru Fukui, Motohiro Izumi, Naoki Yoshimoto, Akira Sugimoto, Hiroaki Nagamine, Koichi Ogawa, Yoshiya Matsumoto, Kenji Sawa, Yoko Tani, Shigeki Mitsuoka, Tetsuya Watanabe, Kazuhisa Asai, Tomoya Kawaguchi
Summary: This study found that the expression of vascular endothelial growth factor receptor 2 in immune cells can affect the therapeutic efficacy of immune-checkpoint inhibitors in patients with advanced non-small cell lung cancer, while the expression in tumor cells does not significantly impact the treatment outcome.
Article
Environmental Sciences
Su Min Ji, Jae-Sun Choi, Ji Young Lee, Sungyeon Kim, Woom-Yee Bae, Ye Won Jang, Ja-Eun Kim, Seung Hyeun Lee, Seungyoon Nam, Joo-Won Jeong
Summary: Fine particulate matter (PM2.5) is associated with worldwide public health problems, including epigenetic and microenvironmental changes in lung cancer. This study found that relatively lower concentrations of PM2.5 increased angiogenic activities in endothelial cells and non-small cell lung carcinoma cells, and induced the expression of hypoxia-inducible factor-1a (HIF-1a) to promote the growth and angiogenesis of lung cancer in a mouse tumor model. Lung cancer patients in countries with high PM2.5 levels had high expression of angiogenic factors such as vascular endothelial growth factor (VEGF), which led to a lower survival rate. These findings provide new insights into the mechanisms of HIF-1a-mediated angiogenesis in lung cancer patients exposed to mild PM2.5.
ENVIRONMENTAL POLLUTION
(2023)
Article
Multidisciplinary Sciences
Chin-Kuo Lin, Tzu-Hsiung Huang, Cheng-Ta Yang, Chung-Sheng Shi
Summary: The study found that lung-recruited monocytes post-VILI are predominantly Ly6C(+low), and pulmonary VEGF decreases initially but increases significantly on days 7 and 14 after injury. There is a strong positive correlation between VEGF expression and alveolar epithelial cell proliferation, and the restoration of pulmonary VEGF by monocytes may play a crucial role in post-VILI lung repair.
Article
Cardiac & Cardiovascular Systems
Sofia-Iris Bibli, Jiong Hu, Mario Looso, Andreas Weigert, Corina Ratiu, Janina Wittig, Maria Kyriaki Drekolia, Lukas Tombor, Voahanginirina Randriamboavonjy, Matthias S. Leisegang, Philipp Goymann, Fredy Delgado Lagos, Beate Fisslthaler, Sven Zukunft, Anastasia Kyselova, Alberto Fernando Oliveira Justo, Juliana Heidler, Diamantis Tsilimigras, Ralf P. Brandes, Stefanie Dimmeler, Andreas Papapetropoulos, Stefan Knapp, Stefan Offermanns, Ilka Wittig, Stephen L. Nishimura, Fragiska Sigala, Ingrid Fleming
Summary: This study investigated the S-sulfhydrome in human endothelial cells and found that S-sulfhydration plays a crucial role in regulating endothelial cell functions, especially in integrins and mechanotransduction. Impaired S-sulfhydration was associated with vascular dysfunction, while H2Sn supplementation improved vascular reactivity, suggesting a potential therapeutic target for vascular diseases.
Review
Cell Biology
Yelda Pakize Kina, Ali Khadim, Werner Seeger, Elie El Agha
Summary: Multiple factors converge to coordinate organogenesis, particularly in the context of lung development where airway branching is considered a rate-limiting step. The reciprocal interaction between the vascular network and airway tree plays a critical role in their patterning, branching, and alignment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Ophthalmology
Tzu-Yi Lin, Yi-Ting Hsieh, Sunir J. J. Garg, Lee-Jen Chen, Kuan-Jen Chen, Wei-Chi Wu, Chi-Chun Lai, Yih-Shiou Hwang, Eugene Yu-Chuan Kang
Summary: This study compared the systemic adverse events (SAEs) of intravitreal dexamethasone and anti-VEGF medications using real-world data. The results showed that both drugs had comparable systemic safety profiles and were effective and safe treatments for ocular diseases.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Oncology
Yu Zhang, Heming Wu, Honghui Luo, Yiqun Luo, Cong Huang
Summary: This study reveals that ATF3 inhibits fibrosis and viability of cardiac fibroblasts by activating the transcription of Cyr61 in stress overload-induced hearts. This finding enhances our understanding of the role of ATF3 in the development of cardiac diseases and provides a new target for the treatment of heart diseases.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Jie Wang, Dan Wang, Xiaobin Ji, Jun Wang, Steven J. Klosterman, Xiaofeng Dai, Jieyin Chen, Krishna V. Subbarao, Xiaojuan Hao, Dandan Zhang
Summary: This study shows that the small cysteine-rich protein VdSCP23 from Verticillium dahliae can inhibit cell necrosis, reactive oxygen species burst, electrolyte leakage, and the expression of defense-related genes in Nicotiana benthamiana. Localization analysis reveals that VdSCP23 is mainly located in the plasma membrane and nucleus of plant cells. The inhibition of immune responses by VdSCP23 is not dependent on its nuclear localization or cysteine residues, but on N-glycosylation sites and the integrity of protein structure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Wei Li, Yi Li, Wei Zhi, Chen Liu, Weize Fan, Qing Miao, Xinshun Gu
Summary: The study found that exosomal Cyr61 levels were significantly elevated in patients with ACS and associated with sex, family history of ACS, and glucose levels. ROC curve analysis showed that exosomal Cyr61 expression could differentiate patients with UAP, AMI, and ACS from healthy individuals. Additionally, exosomal Cyr61 levels were independently correlated with the presence of ACS.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, Research & Experimental
Jiannan Gong, Zihang Feng, Abigail L. Peterson, Jennifer F. Carr, Xuexin Lu, Haifeng Zhao, Xiangming Ji, You-Yang Zhao, Monique E. De Paepe, Phyllis A. Dennery, Hongwei Yao
Summary: The study showed that hyperoxia can exacerbate abnormal endothelial cell proliferation and dysmorphic vascular growth in neonatal mice through the pentose phosphate pathway (PPP), while inhibition of the PPP can reduce these effects.