Evaluation of electrophoretic mobility shift assay as a method to determine plasma protein binding of siRNA

Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria

(2019) Eliane Sardh et al.   NEW ENGLAND JOURNAL OF MEDICINE

Plasma and liver protein binding of GalNAc conjugated siRNA

(2019) Sara C Humphreys et al.   DRUG METABOLISM AND DISPOSITION

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index

(2019) Wen Shen et al.   NATURE BIOTECHNOLOGY

Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol

(2017) Kausik K. Ray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides

(2017) Jeffrey K. Bailey et al.   NUCLEIC ACIDS RESEARCH

Impact of Oligonucleotide Structure, Chemistry, and Delivery Method on In Vitro Cytotoxicity

(2017) Maja M. Janas et al.   Nucleic Acid Therapeutics

Rapid agarose gel electrophoretic mobility shift assay for quantitating protein: RNA interactions

(2016) Jennifer A. Ream et al.   ANALYTICAL BIOCHEMISTRY

Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides

(2015) Richard S. Geary et al.   ADVANCED DRUG DELIVERY REVIEWS

2′-Fluoro-modified phosphorothioate oligonucleotide can cause rapid degradation of P54nrb and PSF

(2015) Wen Shen et al.   NUCLEIC ACIDS RESEARCH

Electrostatic Unfolding and Interactions of Albumin Driven by pH Changes: A Molecular Dynamics Study

(2014) K. Baler et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Bioanalysis for plasma protein binding studies in drug discovery and drug development: views and recommendations of the European Bioanalysis Forum

(2014) Brigitte Buscher et al.   Bioanalysis

Plasma protein binding: From discovery to development

(2013) Tonika Bohnert et al.   JOURNAL OF PHARMACEUTICAL SCIENCES