Article
Gastroenterology & Hepatology
Hironobu Suto, Minoru Oshima, Yasuhisa Ando, Hiroyuki Matsukawa, Shigeo Takahashi, Toru Shibata, Hideki Kamada, Hideki Kobara, Tsutomu Masaki, Kensuke Kumamoto, Yasuyuki Suzuki, Keiichi Okano
Summary: The benefit of preoperative treatment followed by pancreatic resection in older patients with PDAC remains unclear. This study showed that preoperative treatment followed by curative resection could be safely performed in older patients, with similar outcomes as younger patients. Although older patients had a higher frequency of postoperative complications, the prognosis was similar.
Article
Oncology
Shohei Takaichi, Yoshito Tomimaru, Shogo Kobayashi, Keisuke Toya, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Hidenori Takahashi, Tadafumi Asaoka, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study investigated the impact of changes in body composition on postoperative outcomes in patients with PDAC undergoing neoadjuvant chemoradiotherapy. The results showed that loss of skeletal muscle mass during NACRT was an independent risk factor for survival in PDAC patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Laura Maggino, Giuseppe Malleo, Stefano Crippa, Giulio Belfiori, Sara Nobile, Giulia Gasparini, Gabriella Lionetto, Claudio Luchini, Paola Mattiolo, Marco Schiavo-Lena, Claudio Doglioni, Aldo Scarpa, Claudio Bassi, Massimo Falconi, Roberto Salvia
Summary: This study investigated the incidence and pattern of recurrence in patients with initially resectable and borderline resectable pancreatic ductal adenocarcinoma who received post-neoadjuvant pancreatectomy. The results showed that preoperative tumor size <20 mm, normal posttreatment CA19.9 and Delta CA19.9 > 50% were associated with longer recurrence-free survival (RFS) in these patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ayaka Takaori, Daisuke Hashimoto, Tsukasa Ikeura, Takashi Ito, Koh Nakamaru, Masataka Masuda, Shinji Nakayama, So Yamaki, Tomohisa Yamamoto, Kosuke Fujimoto, Yoshiyuki Matsuo, Shohei Akagawa, Mitsuaki Ishida, Kiyoshi Yamaguchi, Seiya Imoto, Kiichi Hirota, Satoshi Uematsu, Sohei Satoi, Mitsugu Sekimoto, Makoto Naganuma
Summary: This study aimed to evaluate the changes in gut microbiota before and after neoadjuvant chemotherapy in patients with resectable and borderline resectable pancreatic ductal adenocarcinoma. The results showed that the diversity of gut microbiota was not significantly affected by neoadjuvant chemotherapy, but the relative abundance of Bifidobacterium genus was lower before neoadjuvant chemotherapy. This suggests that a lower abundance of Bifidobacterium genus before neoadjuvant chemotherapy may be associated with a poorer pathological response to the treatment.
Article
Medicine, General & Internal
Luis Secanella, Juli Busquets, Nuria Pelaez, Maria Sorribas, Berta Laquente, Sandra Ruiz, Thiago Carnaval, Sebastian Videla, Juan Fabregat
Summary: Neoadjuvant treatment plays an important role in ensuring successful resection of pancreatic cancer. However, there is limited research on the predictive factors associated with resection and survival. This study aims to investigate the relationship between CA 19-9 plasmatic levels, tumor anatomical relationship with neighboring vascular structures, and resection and survival in type A BR-PDAC patients.
Article
Oncology
Mohamed Abdelgadir Adam, Alexa Glencer, Samer AlMasri, Sharon Winters, Nathan Bahary, Aatur Singhi, Kenneth K. Lee, Alessandro Paniccia, Amer H. Zureikat
Summary: This study compares neoadjuvant therapy (NAT) with upfront resection (UR) for non-PDAC periampullary adenocarcinomas. The results suggest that NAT may improve survival in patients with extrahepatic cholangiocarcinoma.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Amro M. Abdelrahman, Ajit H. Goenka, Roberto Alva-Ruiz, Jennifer A. Yonkus, Jennifer L. Leiting, Rondell P. Graham, Kenneth W. Merrell, Cornelius A. Thiels, Christopher L. Hallemeier, Susanne G. Warner, Michael G. Haddock, Travis E. Grotz, Nguyen H. Tran, Rory L. Smoot, Wen Wee Ma, Sean P. Cleary, Robert R. McWilliams, David M. Nagorney, Thorvardur R. Halfdanarson, Michael L. Kendrick, Mark J. Truty
Summary: Among patients with post-NAT resected BR/LA PDAC, FDG-PET highly predicts pathologic response and survival, superior to biochemical responses alone. Given the poor ability of anatomic imaging or biochemical markers to assess NAT responses in these patients, FDG-PET is a preoperative metric of NAT efficacy, thereby allowing potential therapeutic alterations and surgical treatment decisions. We suggest that FDG-PET should be an adjunct and recommended modality during the NAT phase of care for these patients.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)
Article
Oncology
Jacob L. van Dam, Quisette P. Janssen, Marc G. Besselink, Marjolein Y. Homs, Hjalmar C. van Santvoort, Geertjan van Tienhoven, Roeland F. de Wilde, Johanna W. Wilmink, Casper H. J. van Eijck, Bas Groot Koerkamp
Summary: This study found that neoadjuvant therapy can improve overall survival in patients with borderline resectable pancreatic cancer. However, more evidence is needed to determine whether it also improves survival in patients with resectable pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2022)
Review
Gastroenterology & Hepatology
Shigenori Ei, Shinichiro Takahashi, Toshihito Ogasawara, Taro Mashiko, Yoshihito Masuoka, Toshio Nakagohri
Summary: Resection is the only curative treatment for pancreatic ductal adenocarcinoma (PDAC), but the 5-year survival rate remains low and more effective therapy is needed. Recent studies have focused on perioperative treatment for resectable and borderline resectable PDAC, showing promising results. This review compares the difference between Asian and Western countries in perioperative treatment for PDAC.
Review
Oncology
Chenqi Wang, Guang Tan, Jie Zhang, Bin Fan, Yunlong Chen, Dan Chen, Lili Yang, Xiang Chen, Qingzhu Duan, Feiliyan Maimaiti, Jian Du, Zhikun Lin, Jiangning Gu, Haifeng Luo
Summary: The incidence of pancreatic ductal adenocarcinoma (PDAC) has been increasing in recent years, and its clinical diagnosis and treatment remain challenging. Neoadjuvant therapy (NAT) aims to improve overall survival, but there are still many controversies surrounding its role in PDAC treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Atsushi Oba, Y. H. Andrew Wu, Kathryn L. Colborn, Sana D. Karam, Cheryl Meguid, Mohammed H. Al-Musawi, Quoc R. Bao, Ana L. Gleisner, Steven Ahrendt, Richard D. Schulick, Marco Del Chiaro
Summary: This study evaluated the treatment outcome of neoadjuvant radiotherapy (RT) compared to neoadjuvant chemotherapy (NAC) in patients with pancreatic ductal adenocarcinoma (PDAC). Despite its association with negative margin resection, neoadjuvant chemoradiotherapy did not show a survival benefit over neoadjuvant chemotherapy and had a higher 90-day mortality rate.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Oncology
Ana Acuna-Villaorduna, Viswanathan Shankar, Michael Wysota, Amanda Jirgal, Rafi Kabarriti, Sarah Bellemare, Inessa Goldman, Andreas Kaubisch, Santiago Aparo, Sanjay Goel, Jennifer Chuy
Summary: This study evaluated the efficacy of FOLFIRINOX chemotherapy followed by gemcitabine-based chemoradiation as neoadjuvant therapy for borderline-resectable pancreatic ductal adenocarcinoma (BR-PDAC). The results showed a favorable RO resection rate of 55.6% and good tolerability of the regimen.
Article
Radiology, Nuclear Medicine & Medical Imaging
Seung-seob Kim, Sunyoung Lee, Hee Seung Lee, Seungmin Bang, Mi-Suk Park
Summary: The study identified CA 19-9 > 1000 U/mL and non-homogeneous enhancement as predictors of shorter overall survival in PDAC patients. The presence of positive lymph nodes on CT was a poor prognostic factor for the CTx group, while CA 19-9 > 1000 U/mL was a poor prognostic factor for the CRT group.
ABDOMINAL RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Mark Jaradeh, Wickii T. Vigneswaran, Wissam Raad, James Lubawski, Richard Freeman, Zaid M. Abdelsattar
Summary: This study compares the short-term and long-term outcomes of neoadjuvant chemotherapy alone versus chemoradiation therapy followed by sleeve lung resection in patients with locally advanced resectable NSCLC. The results show that neoadjuvant chemoradiation therapy is associated with a 5-fold increase in 90-day mortality without a significant difference in overall survival compared to neoadjuvant chemotherapy alone.
ANNALS OF THORACIC SURGERY
(2022)
Article
Oncology
Satoshi Nishiwada, Masayuki Sho, Ya Cui, Kensuke Yamamura, Takahiro Akahori, Kenji Nakagawa, Minako Nagai, Kota Nakamura, Tadataka Takagi, Naoya Ikeda, Wei Li, Hideo Baba, Ajay Goel
Summary: A novel gene signature has been developed to predict sensitivity to NACRT in PDAC patients, demonstrating robust performance even in preoperative settings. This may have significant clinical implications for optimizing treatment strategies in PDAC patients.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Cardiac & Cardiovascular Systems
Hirosuke Yamaji, Shunichi Higashiya, Takashi Murakami, Hiroshi Kawamura, Masaaki Murakami, Shigeshi Kamikawa, Shozo Kusachi
Summary: The study found that in patients undergoing CTIA adjunctive to AF ablation, the rates of clinical AFL occurrence and CTI reconduction were relatively low, demonstrating superiority compared to other ablation methods.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2022)
Correction
Infectious Diseases
Kazuo Imai, Noriomi Ishibashi, Masahiro Kodana, Norihito Tarumoto, Jun Sakai, Toru Kawamura, Shinichi Takeuchi, Yoshitada Taji, Yasuhiro Ebihara, Kenji Ikebuchi, Takashi Murakami, Takuya Maeda, Kotaro Mitsutake, Shigefumi Maesaki
BMC INFECTIOUS DISEASES
(2022)
Article
Oncology
Fumiaki Sato, Atsunobu Sagara, Kaede Tajima, Shotaro Miura, Kenjiro Inaba, Yusuke Ando, Teruaki Oku, Takashi Murakami, Yoshinori Kato, Tetsuro Yumoto
Summary: COL8A1 is highly expressed in TNBC cell lines, especially in the MSL subtype, and its overexpression promotes TNBC growth through FAK/Src activation. Loss of COL8A1 inhibits TNBC spheroid/tumor growth and metastasis. Targeting COL8A1 may be an effective treatment for TNBC.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Yasuyuki Bito, Takanobu Aoyama, Masanori Sakaguchi, Yuriko Kiriya, Akihiro Sumiya, Masataro Doi, Takashi Murakami
CIRCULATION JOURNAL
(2022)
Article
Immunology
Atsushi Morita, Sho Hosaka, Kazuo Imagawa, Takumi Ishiodori, Yoshihiro Nozaki, Takashi Murakami, Hidetoshi Takada
Summary: This study elucidates the immunological characteristics of a Japanese patient with MIS-C, revealing the time course of peripheral immunophenotypes along with the clinical course and suggesting that immunological activation against the SARS-CoV-2 spike protein plays a central role in the etiology of MIS-C.
CLINICAL IMMUNOLOGY
(2022)
Letter
Gastroenterology & Hepatology
Takashi Murakami, Takashi Yao, Akihito Nagahara
DIGESTIVE ENDOSCOPY
(2022)
Review
Gastroenterology & Hepatology
Takashi Murakami, Taro Kurosawa, Hirofumi Fukushima, Tomoyoshi Shibuya, Takashi Yao, Akihito Nagahara
Summary: The term sessile serrated lesion (SSL) was introduced in the 2019 WHO Classification of Tumours of the Digestive System as an early precursor lesion in the serrated neoplasia pathway. These lesions can quickly progress into dysplastic or invasive carcinomas with high lymphatic invasion potential.
DIGESTIVE ENDOSCOPY
(2022)
Article
Pathology
Taro Kurosawa, Takashi Murakami, Yuya Yamashiro, Hiroyuki Terukina, Takuo Hayashi, Tsuyoshi Saito, Shuko Nojiri, Kazuhiro Sakamoto, Akihito Nagahara, Takashi Yao
Summary: This study classified a large number of colorectal carcinoma (CRC) cases based on mucin phenotypes and investigated their correlation with tumor development, biological behavior, and prognosis. The results showed that small-intestinal type and unclassified type had a poor prognosis in CRCs. Furthermore, colorectal adenocarcinoma with enteroblastic differentiation (CAED) mostly belonged to the small-intestinal type or unclassified type. These findings suggest that the phenotypic classification is useful for predicting the prognosis of CRCs, and CAED might reflect the aggressive behavior and poor prognosis of small-intestinal and unclassified types.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Immunology
Takashi Imai, Ha Ngo-Thanh, Kazutomo Suzue, Aoi Shimo, Akihiro Nakamura, Yutaka Horiuchi, Hajime Hisaeda, Takashi Murakami
Summary: This study aims to develop a malaria vaccine that provides cross-strain protection. Results showed that inoculation of mice with a heterologous live-vaccine prevented the development of experimental cerebral malaria (ECM) and protected the blood-organ barriers from infection. The immune response induced by the live vaccine included cross-reactive antibodies and IL-10-mediated host protection against ECM.
Article
Cardiac & Cardiovascular Systems
Hitoshi Mori, Naokata Sumitomo, Kenta Tsutsui, Hideo Fukunaga, Hidemori Hayashi, Hiroshi Nakajima, Shota Muraji, Taisuke Nabeshima, Daisuke Kawano, Yoshifumi Ikeda, So Asano, Junichi Nitta, Shigeo Watanabe, Tatsunori Hokosaki, Seiichi Sato, Toshiyuki Chisaka, Takashi Higaki, Tadashi Nakajima, Shuntaro Tamura, Yoshiaki Kaneko, Kentaro Ikeda, Ayako Okada, Hideki Kobayashi, Hirohiko Motoki, Hitoshi Minamiguchi, Tomohiko Imamura, Satoshi Shizuta, Mitsuharu Kawamura, Yumi Munetsugu, Tsugutoshi Suzuki, Takashi Murakami, Hitoshi Horigome, Tsutomu Wada, Motoki Takamuro, Junichi Ozawa, Hiroshi Suzuki, Daisuke Izumi, Sou Otsuki, Masaomi Chinushi, Ken Kato, Masaru Miura, Jun Maeda, Masato Fukunaga, Hidekazu Kondo, Naohiko Takahashi, Takeshi Tobiume, Itsuro Morishima, Kenji Kuraishi, Kentaro Nakamura, Hiroshi Hayashi, Hirohiko Suzuki, Yukihiko Yoshida, Seiji Fukamizu, Rintaro Hojo, Norihito Nuruki, Masao Yoshinaga, Kentaro Hayashi, Hidehira Fukaya, Jun Kishihara, Toshiki Kobayashi, Ritsushi Kato
Summary: This study investigated the utility and safety of subcutaneous implantable cardioverter defibrillators (S-ICDs) in patients <= 18 years old. The results suggested that S-ICDs can effectively prevent sudden cardiac death in the pediatric population with a low incidence of lead complications or device infections. The number of suitable sensing vectors did not change during the patients' growth.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hirosuke Yamaji, Shunichi Higashiya, Takashi Murakami, Hiroshi Kawamura, Masaaki Murakami, Shigeshi Kamikawa, Shozo Kusachi
Summary: The purpose of this study is to determine the optimal method for preventing right phrenic nerve injury (PNI) in superior vena cava isolation (SVCI). The introduction of various monitoring systems has led to a decrease in PNI incidence, but only the application of high-power, short-duration radiofrequency energy on risk points tagged by a 3-dimensional electro-anatomical mapping (EAM) system completely prevents PNI.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Showkat Rashid, Takashi Murakami, Hiroshi Koganezawa, Yusuke Yoshigoe, Shoichi Hosoya, Shinichi Saito
Summary: Oxidative dimerization of terminal alkynes (Glaser coupling) triggered by spirofluorene derived macrocyclic phenanthroline-Cu complexes was used to synthesize a series of novel [2]rotaxanes. The size and structural variations among the components and their effects on the dynamic behavior were investigated in detail using H-1 and F-19 NMR spectroscopy. Non-symmetric distribution of the ring component along the axle component was observed in the NMR spectra of rotaxanes with substituted macrocyclic components with low symmetry, and localization of the ring component near the 1,3-diyne moiety was observed in some [2]rotaxanes.
NEW JOURNAL OF CHEMISTRY
(2023)
Review
Clinical Neurology
Sho Hanai, Ai Muroi, Daisuke Hitaka, Takashi Murakami, Masayuki Sato, Yuji Matsumaru, Eiichi Ishikawa
Summary: We present a neonatal case of DSM that was diagnosed prenatally and treated via endovascular intervention in the early postnatal period. The patient presented with a large DSM involving the torcular Herophilion prenatal magnetic resonance imaging (MRI). The neonate underwent endovascular occlusion via the umbilical artery, successfully treating the DSM.
CHILDS NERVOUS SYSTEM
(2023)
Review
Obstetrics & Gynecology
Shunichiro Tsuji, Yuri Nobuta, Tetsuro Hanada, Aike Takebayashi, Ayako Inatomi, Akimasa Takahashi, Tsukuru Amano, Takashi Murakami
Summary: This review summarizes the definition, prevalence, and etiology of Cesarean scar defects (CSD), as well as the pathophysiology and treatment of Cesarean scar disorder (CSDi), focusing on surgical therapy and examining the effects and procedures of laparoscopy, hysteroscopy, and transvaginal surgery. The definition of CSD was proposed as an anechoic lesion with a depth of at least 2 mm, while the incidence of CSD depends on the number, procedure, and situation of cesarean sections. Histopathological findings in CSD include fibrosis and adenomyosis, and chronic inflammation in the uterine and pelvic cavities affects fertility in women with CSDi. Although the surgical procedures are not standardized, laparoscopic, hysteroscopic, and transvaginal surgeries have shown effectiveness.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2023)
Meeting Abstract
Oncology
Seiichiro Inoue, Yutaka Horiuchi, Yuta Takeuchi, Takashi Murakami, Akio Odaka
PEDIATRIC BLOOD & CANCER
(2022)
