Article
Allergy
Yohko Kitagawa, Yuri Kawasaki, Yuichi Yamasaki, Naotomo Kambe, Syuji Takei, Megumu K. Saito
Summary: IFN-gamma stimulation plays a key role in driving aberrant inflammatory responses in BS-associated macrophages. However, long-term treatment with anti-TNF agents can ameliorate these abnormalities, suggesting a prerequisite role of TNF or similar cytokines in inducing proinflammatory signaling during macrophage development in BS patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Qian Zhang, Kun Yu, Yazhen Cao, Yanli Luo, Yan Liu, Caiyan Zhao
Summary: The study revealed that miR-125b expression is up-regulated in NAFLD patients, along with increased levels of inflammatory-related genes in the liver. MiR-125b promotes NF-kappa B-mediated inflammatory responses by directly targeting TNFAIP3, suggesting it as a potential target for treating NAFLD.
Article
Cell Biology
Ricardo J. Antonia, Eveliina Karelehto, Kan Toriguchi, Mary Matli, Robert S. Warren, Lawrence M. Pfeffer, David B. Donner
Summary: The study reveals that TNF activates STAT3, which in turn regulates the expression of inflammatory chemokines. Furthermore, Tnfaip3/A20 is identified as a downstream target of STAT3, and it functions to restrict TNF-induced inflammation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Cell Biology
Sydney Diep, Mahita Maddukuri, Stephanie Yamauchi, Ganamee Geshow, Nikki A. Delk
Summary: IL-1 inflammatory signaling plays a crucial role in breast cancer progression and therapeutic resistance by promoting cell proliferation, stem cell expansion, angiogenesis, metastasis, regulating intracellular signaling, and allowing tumor cells to evade therapy.
Article
Immunology
Yingchun Su, Yanting Liu, Dewei He, Guiqiu Hu, Hefei Wang, Bojian Ye, Yuan He, Xiyu Gao, Dianfeng Liu
Summary: Parkinson's disease is a common disease caused by degeneration of the central nervous system, characterized by the death of dopaminergic neurons. Neuroinflammation, particularly the excessive activation of microglia, plays a significant role in its pathogenesis. Hordenine has been found to have anti-oxidant and anti-inflammatory properties, and this study reveals its potential in inhibiting neuroinflammation by suppressing microglial activation and protecting dopaminergic neurons.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Ana Merino-Vico, Jan Piet van Hamburg, Paul Tuijnenburg, Giulia Frazzei, Aram Al-Soudi, Carlo G. Bonasia, Boy Helder, Abraham Rutgers, Wayel H. Abdulahad, Coen A. Stegeman, Jan-Stephan Sanders, Laura Bergamaschi, Paul A. Lyons, Theo Bijma, Laura van Keep, Kirsten Wesenhagen, Aldo Jongejan, Henric Olsson, Niek de Vries, Taco W. Kuijpers, Peter Heeringa, Sander W. Tas
Summary: B lineage cells play a critical role in ANCA-associated vasculitis (AAV), and the transcription factor NF-kappa B may be a potential therapeutic target for AAV and other autoimmune diseases with prominent B cell involvement.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Nutrition & Dietetics
Shanshan Chen, Honghan Liu, Shimiao Wang, Hongbo Jiang, Le Gao, Lu Wang, Lesheng Teng, Chunyue Wang, Di Wang
Summary: The neuroprotective mechanism of Verbascoside (VB) was explored in this study. Proteomic analysis and immunological methods revealed that VB exerts its neuroprotective effect by inhibiting neuroinflammation and modulating the NF-kappa B-p65 pathway. These findings suggest that VB could be a potential candidate drug for the prevention and treatment of Alzheimer's disease (AD).
Article
Immunology
Lin Wei, Xiaowen Yang, Jie Wang, Zhixiao Wang, Qiguang Wang, Yan Ding, Aiqing Yu
Summary: Cellular senescence is a fundamental activity driving the aging process and is closely associated with age-related diseases, including Alzheimer's disease (AD). In this study, the elevated levels of lactic acid in senescent microglia and hippocampus tissues of naturally aged mice and AD mice models were quantified. The study also identified the role of H3K18la/NF?B axis in modulating the production of IL-6 and IL-8, which are components of the senescence-associated secretory phenotype (SASP).
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Immunology
Zhending Gan, Meiyu Zhang, Donghui Xie, Xiaoyan Wu, Changming Hong, Jian Fu, Lijuan Fan, Shengyi Wang, Sufang Han
Summary: Glycine, acting as an inhibitory neurotransmitter, not only affects the functions of macrophages but also shapes their polarization through cellular signaling pathways and microRNAs. Additionally, glycine has beneficial effects in preventing and treating macrophage-associated diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jason W. An, Pallavi Pimpale-Chavan, Deborah L. Stone, Marcia Bandeira, Fatma Dedeoglu, Jeffrey Lo, John Bohnsack, Sofia Rosenzweig, Oskar Schnappauf, Dilan Dissanayake, Linda T. Hiraki, Daniel L. Kastner, Christina Pelajo, Ronald M. Laxer, Ivona Aksentijevich
Summary: RELA haploinsufficiency is an autoinflammatory condition characterized by intermittent fevers and mucocutaneous ulcerations. Only eight cases have been reported in the literature, but this study adds four families with three novel and one previously described pathogenic variant in RELA. Clinical features include orogenital ulcers, rash, joint inflammation, and fever. Treatment with glucocorticoids, colchicine, and TNF inhibitors has shown benefit. The study highlights the importance of the NF-kappa B pathway and the regulatory role of RELA in mucosal homeostasis, and suggests considering RELA associated inflammatory disease in patients with Behcet's Disease, particularly those with early onset and/or a strong family history.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Bo Wu, Lihua Qiang, Yong Zhang, Yesheng Fu, Mengyuan Zhao, Zehui Lei, Zhe Lu, Yan-Ge Wei, Hongmiao Dai, Yingwei Ge, Mingqiu Liu, Xuemei Zhou, Zhiqiang Peng, Hongchang Li, Chun-Ping Cui, Jing Wang, Hui Zheng, Cui Hua Liu, Lingqiang Zhang
Summary: The E3 ubiquitin ligase (E3)-mediated ubiquitination and deubiquitinase (DUB)-mediated deubiquitination play crucial roles in colonic inflammation. Ovarian tumor deubiquitinase 1 (OTUD1) inhibits RIPK1-mediated NF-kappa B activation to alleviate inflammation, with lower expression in UC patients. OTUD1 is a potential target for treating IBD due to its regulatory role in intestinal inflammation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Giovanna M. Bernal, Longtao Wu, David J. Voce, Ralph R. Weichselbaum, Bakhtiar Yamini
Summary: This study found that the p52 subunit increases in the nucleus of cells during senescence, and factors in the conditioned media play a role in promoting p52 nuclear translocation. Additionally, mature p52 can induce cellular senescence. These findings support the observation of increased p52 in aged tissue and suggest that p52 contributes to organismal aging.
CELL AND BIOSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Li Tao, Xiaomeng Ren, Wenhui Zhai, Zheng Chen
Summary: The non-canonical NF-kappa B signaling pathway plays a crucial role in liver diseases by regulating liver homeostasis and participating in various pathological processes. Small-molecule inhibitors targeting this pathway have shown potential in the treatment of liver injuries.
Article
Oncology
Weijun Wu, Jinghuan Wang, Chenxi Xiao, Zhenghua Su, Haibi Su, Wen Zhong, Jianchun Mao, Xinhua Liu, Yi Zhun Zhu
Summary: This study confirmed that cytoplasmic protein TRAF2 can be methylated by SMYD2 and contribute to the continuous activation of NF-kappa B signaling pathway. Knocking down SMYD2 showed varying degrees of mitigation in acute and chronic inflammation mouse models. Moreover, lysine-specific demethylase LSD1 was found to resist the methylation of TRAF2 induced by SMYD2.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Wenqing Li, Fubo Han, Kaifan Tang, Chengjie Ding, Fen Xiong, Yina Xiao, Chen Li, Qian Liang, Kwang Youl Lee, Ik-Soo Lee, Hongchang Gao
Summary: Demethylzeylasteral exhibits promising potential as a treatment for colon cancer by inhibiting S100A11 expression and directly interacting with it to attenuate cell proliferation. NF-kappa B acts as an upstream transcription factor regulating S100A11 expression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Genetics & Heredity
Natalie Deuitch, Sandra Soo-Jin Lee, Danton Char
JOURNAL OF GENETIC COUNSELING
(2020)
Review
Biochemistry & Molecular Biology
Cornelia Cudrici, Natalie Deuitch, Ivona Aksentijevich
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Immunology
Oskar Schnappauf, Qing Zhou, Natalia Sampaio Moura, Amanda K. Ombrello, Drew G. Michael, Natalie Deuitch, Karyl Barron, Deborah L. Stone, Patrycja Hoffmann, Michael Hershfield, Carolyn Applegate, Hans T. Bjornsson, David B. Beck, P. Dane Witmer, Nara Sobreira, Elizabeth Wohler, John A. Chiorini, Clifton L. Dalgard, Daniel L. Kastner, Ivona Aksentijevich
JOURNAL OF CLINICAL IMMUNOLOGY
(2020)
Article
Medicine, General & Internal
David B. Beck, Marcela A. Ferrada, Keith A. Sikora, Amanda K. Ombrello, Jason C. Collins, Wuhong Pei, Nicholas Balanda, Daron L. Ross, Daniela Ospina Cardona, Zhijie Wu, Bhavisha Patel, Kalpana Manthiram, Emma M. Groarke, Fernanda Gutierrez-Rodrigues, Patrycja Hoffmann, Sofia Rosenzweig, Shuichiro Nakabo, Laura W. Dillon, Christopher S. Hourigan, Wanxia L. Tsai, Sarthak Gupta, Carmelo Carmona-Rivera, Anthony J. Asmar, Lisha Xu, Hirotsugu Oda, Wendy Goodspeed, Karyl S. Barron, Michele Nehrebecky, Anne Jones, Ryan S. Laird, Natalie Deuitch, Dorota Rowczenio, Emily Rominger, Kristina V. Wells, Chyi-Chia R. Lee, Weixin Wang, Megan Trick, James Mullikin, Gustaf Wigerblad, Stephen Brooks, Stefania Dell'Orso, Zuoming Deng, Jae J. Chae, Alina Dulau-Florea, May C. V. Malicdan, Danica Novacic, Robert A. Colbert, Mariana J. Kaplan, Massimo Gadina, Sinisa Savic, Helen J. Lachmann, Mones Abu-Asab, Benjamin D. Solomon, Kyle Retterer, William A. Gahl, Shawn M. Burgess, Ivona Aksentijevich, Neal S. Young, Katherine R. Calvo, Achim Werner, Daniel L. Kastner, Peter C. Grayson
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Rheumatology
Daniella Muallem Schwartz, Moses M. Kitakule, Brian L. P. Dizon, Cristhian Gutierrez-Huerta, Sarah A. Blackstone, Aarohan M. Burma, Aran Son, Natalie Deuitch, Sofia Rosenzweig, Hirsh Komarow, Deborah L. Stone, Anne Jones, Michele Nehrebecky, Patrycja Hoffmann, Tina Romeo, Adriana Almeida de Jesus, Sara Alehashemi, Megha Garg, Sofia Torreggiani, Gina A. Montealegre Sanchez, Katelin Honer, Gema Souto Adeva, Karyl S. Barron, Ivona Aksentijevich, Amanda K. Ombrello, Raphaela Goldbach-Mansky, Daniel L. Kastner, Joshua D. Milner, Pamela Frischmeyer-Guerrerio
Summary: This study investigated allergic, immunological, and clinical phenotypes in patients with monogenic autoinflammatory diseases (AID). The results showed that CAPS is characterized by an enhanced Type 2 immune response, while FMF and CANDLE are associated with reduced Type 2 responses. DADA2 is linked to reduced Type 2 responses but a high rate of physician-diagnosed allergies.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Letter
Immunology
Li Guo, Jun Wang, Xinghui Yang, Rongjun Zheng, Natalie Deuitch, Panfeng Tao, Qing Zhou
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Dana B. Gal, Natalie Deuitch, Sandra Soo Jin Lee, Rosalie Tang Simon, Danton S. Char
Summary: Families' perceptions of genomic sequencing in critical cardiac disease may strain their overall trust in the health system, potentially hindering the realization of the potential benefits genomic sequencing could offer.
PEDIATRIC CRITICAL CARE MEDICINE
(2021)
Article
Genetics & Heredity
Natalie T. Deuitch, Erika Beckman, Meghan C. Halley, Jennifer L. Young, Chloe M. Reuter, Jennefer Kohler, Jonathan A. Bernstein, Matthew T. Wheeler, Kelly E. Ormond, Holly K. Tabor
Summary: Parents of children with undiagnosed conditions struggle to find information and support, often turning to social media for connections with similar families. While they find valuable information, interpreting its relevance to their child's condition can be difficult. Social support and access to others' experiences are highly valued but emotionally challenging, especially when facing poor outcomes in similar families. Balancing concerns about privacy with the benefits of data sharing for diagnosis is important for these families.
JOURNAL OF GENETIC COUNSELING
(2021)
Article
Allergy
Natalie T. Deuitch, Dan Yang, Pui Y. Lee, Xiaomin Yu, Natalia Sampaio Moura, Oskar Schnappauf, Amanda K. Ombrello, Deborah Stone, Hye Sun Kuehn, Sergio D. Rosenzweig, Patrycja Hoffmann, Cornelia Cudrici, Deborah M. Levy, Elizabeth Kessler, Jennifer B. Soep, Arielle D. Hay, Austin Dalrymple, Yu Zhang, Li Sun, Qiuye Zhang, Xuemei Tang, Yuan Wu, Koneti Rao, Haibo Li, Hong Luo, Yao Zhang, Jon M. Burnham, Manfred Boehm, Karyl Barron, Daniel L. Kastner, Ivona Aksentijevich, Qing Zhou
Summary: This study investigates the cellular mechanisms underlying the response to TNF inhibitor therapy in patients with DADA2 and identifies the pathological features associated with treatment response. TNFi treatment reduces inflammation, corrects skewed macrophage differentiation, and restores endothelial cell integrity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Karyl S. Barron, Ivona Aksentijevich, Natalie T. Deuitch, Deborah L. Stone, Patrycja Hoffmann, Ryan Videgar-Laird, Ariane Soldatos, Jenna Bergerson, Camilo Toro, Cornelia Cudrici, Michele Nehrebecky, Tina Romeo, Anne Jones, Manfred Boehm, Jennifer A. Kanakry, Dimana Dimitrova, Katherine R. Calvo, Hawwa Alao, Devika Kapuria, Gil Ben-Yakov, Dominique C. Pichard, Londa Hathaway, Alessandra Brofferio, Elisa McRae, Natalia Sampaio Moura, Oskar Schnappauf, Sofia Rosenzweig, Theo Heller, Edward W. Cowen, Daniel L. Kastner, Amanda K. Ombrello
Summary: The deficiency of adenosine deaminase 2 (DADA2) is a wide-ranging disease with multiple systemic manifestations and overlapping phenotypes. This study provides a long-term follow-up of DADA2, highlighting the clinical heterogeneity and the potential for phenotypic evolution.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Christina Torres Kozycki, Shilpa Kodati, Laryssa Huryn, Hongying Wang, Blake M. Warner, Priyam Jani, Dima Hammoud, Mones S. Abu-Asab, Yingyos Jittayasothorn, Mary J. Mattapallil, Wanxia Li Tsai, Ehsan Ullah, Ping Zhou, Xiaoying Tian, Ariane Soldatos, Niki Moutsopoulos, Marie Kao-Hsieh, Theo Heller, Edward W. Cowen, Chyi-Chia Richard Lee, Camilo Toro, Shelley Kalsi, Zohreh Khavandgar, Alan Baer, Margaret Beach, Debra Long Priel, Michele Nehrebecky, Sofia Rosenzweig, Tina Romeo, Natalie Deuitch, Laurie Brenchley, Eileen Pelayo, Wadih Zein, Nida Sen, Alexander H. Yang, Gary Farley, David A. Sweetser, Lauren Briere, Janine Yang, Fabiano de Oliveira Poswar, Ida Schwartz, Tamires Silva Alves, Perrine Dusser, Isabelle Kone-Paut, Isabelle Touitou, Salah Mohamed Titah, Petrus Martin van Hagen, Rogier T. A. van Wijck, Peter J. van der Spek, Hiromi Yano, Andreas Benneche, Ellen M. Apalset, Ragnhild Wivestad Jansson, Rachel R. Caspi, Douglas Byron Kuhns, Massimo Gadina, Hidetoshi Takada, Hiroaki Ida, Ryuta Nishikomori, Elena Verrecchia, Eugenio Sangiorgi, Raffaele Manna, Brian P. Brooks, Lucia Sobrin, Robert Hufnagel, David Beck, Feng Shao, Amanda K. Ombrello, Ivona Aksentijevich, Daniel L. Kastner
Summary: This study discovered that ROSAH syndrome is an autoinflammatory disease caused by ALPK1 gene mutations. Patients with ROSAH syndrome often exhibit signs of inflammation and show sensitivity to anti-cytokine therapy.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Guo-min Li, Xu Han, Ye Wu, Wei Wang, Hong-xia Tang, Mei-ping Lu, Xue-mei Tang, Yi Lin, Fan Deng, Jun Yang, Xin-ning Wang, Cong-cong Liu, Wen-jie Zheng, Bing-bing Wu, Fang Zhou, Hong Luo, Liang Zhang, Hai-mei Liu, Wan-zhen Guan, Shi-hao Wang, Pan-feng Tao, Tai-jie Jin, Ran Fang, Yuan Wu, Jie Zhang, Yao Zhang, Tian-nan Zhang, Wei Yin, Li Guo, Wen-jing Tang, Hong Chang, Qiu-ye Zhang, Xiao-zhong Li, Jian-guo Li, Zhi-xuan Zhou, Si-rui Yang, Kang-kang Yang, Hong Xu, Hong-mei Song, Natalie T. Deuitch, Pui Y. Lee, Qing Zhou, Li Sun
Summary: This study aimed to systematically investigate deficiency of adenosine deaminase 2 (DADA2) in the Chinese population. A retrospective analysis of 30 DADA2 patients identified through whole exome sequencing was conducted. The patients commonly presented with systemic inflammation, vasculitis, and hypogammaglobinemia, with two patients dying from complications. TNF inhibitors were the first-line treatment for vascular phenotypes, while hematopoietic stem cell transplantation may be beneficial for patients with hematological disease or refractory to TNF inhibitors.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Computer Science, Information Systems
Diana Cagliero, Natalie Deuitch, Nigam Shah, Chris Feudtner, Danton Char
Summary: Objective of this case study is to identify ethical challenges in ML-HCA for advanced care planning by using a stakeholder values-collision approach. Five values-collisions were identified through interviews, which mark areas of ethical and value tension. Based on these findings, the ML design team prioritized alternative workflow strategies, clarification of predictions, and protection of research from scrutiny until endpoint driven studies were completed.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2023)
Article
Genetics & Heredity
Natalie Deuitch, Shao-Tzu Li, Eliza Courtney, Tarryn Shaw, Rebecca Dent, Veronique Tan, Lauren Yackowski, Rebecca Torene, Windy Berkofsky-Fessler, Joanne Ngeow
HUMAN GENOME VARIATION
(2020)