Article
Gastroenterology & Hepatology
Laure Elkrief, Marie Lazareth, Sylvie Chevret, Valerie Paradis, Marta Magaz, Lorraine Blaise, Laura Rubbia-Brandt, Lucile Moga, Francois Durand, Audrey Payance, Aurelie Plessier, Cendrine Chaffaut, Dominique Valla, Marion Malphettes, Alba Diaz, Jean-Charles Nault, Pierre Nahon, Etienne Audureau, Vlad Ratziu, Laurent Castera, Juan-Carlos Garcia Pagan, Nathalie Ganne-Carrie, Pierre-Emmanuel Rautou
Summary: This retrospective multicenter study evaluated the accuracy of transient elastography (TE-LSM) in discriminating between Porto-sinusoidal vascular liver disease (PSVD) and cirrhosis in patients with signs of portal hypertension. The study found that TE-LSM < 10 kPa strongly suggests PSVD, while PSVD is highly unlikely when TE-LSM is >20 kPa in patients with signs of portal hypertension.
Review
Gastroenterology & Hepatology
Pinky Juneja, Dinesh M. Tripathi, Savneet Kaur
Summary: The gut lymphatic system plays a significant role in maintaining gut health, but it is one of the least studied physiological systems. The gut-liver axis is crucial in the pathogenesis of liver diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Xiaocen Zhang, Katelin Marie Durham, Alexander Austin Garza, Arvind R. Murali
Summary: PSVD is a newly named condition that represents non-cirrhotic portal hypertension with characteristic histology and the absence of portal vein thrombosis. It is a more inclusive definition than previously recognized idiopathic non-cirrhotic portal hypertension. However, there is limited data available on PSVD patients.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Philipp Douschan, Gabor Kovacs, Teresa Sassmann, Vanessa Stadlbauer, Alexander Avian, Vasile Foris, Elisabeth Tatscher, Franziska Durchschein, Florian Rainer, Walter Spindelboeck, Martin Wagner, Daniela Kniepeiss, Gernot Zollner, Gerhard Bachmaier, Peter Fickert, Horst Olschewski, Rudolf E. Stauber
Summary: This study investigated the prevalence of portopulmonary hypertension and hepatopulmonary syndrome in patients with chronic liver disease, and found that severe portopulmonary hypertension and hepatopulmonary syndrome were rare, while mild to moderate hepatopulmonary syndrome and pulmonary hypertension were more common.
RESPIRATORY MEDICINE
(2022)
Review
Physiology
Tilman Sauerbruch, Martin Hennenberg, Jonel Trebicka, Ulrich Beuers
Summary: This review examines the role of bile acids in the hyperdynamic circulatory disturbance of liver cirrhosis, and suggests potential ways to influence hemodynamic disorder through modulation of the bile acid pool or dysbiosis. Limited evidence and lack of long-term studies exist on this topic.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lei Zheng, Zhifeng Zhao, Jiayun Lin, Hongjie Li, Guangbo Wu, Xiaoliang Qi, Xiaolou Lou, Yongyang Bao, Haizhong Huo, Meng Luo
Summary: Telmisartan ameliorates cirrhosis-induced portal hypertension by reducing liver fibrosis, inflammation responses, angiogenesis, and vascular remodeling. KLF-4 and eNOS may be potential molecular targets for the management of cirrhosis-associated portal hypertension.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefanie J. Hectors, Octavia Bane, Paul Kennedy, Jordan Cuevas, Swan Thung, Aaron Fischman, Scott L. Friedman, Thomas D. Schiano, Bachir Taouli
Summary: The results of this study demonstrate the potential utility of hepatocyte uptake parameters and spleen interstitial fraction obtained with gadoxetate DCE-MRI for the diagnosis of portal hypertension and clinically significant portal hypertension. Liver uptake rate shows good diagnostic performance for the diagnosis of portal hypertension, while the combination of liver uptake rate with spleen interstitial fraction exhibits excellent diagnostic performance for the diagnosis of clinically significant portal hypertension.
EUROPEAN RADIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Debora Bizzaro, Chiara Becchetti, Silvia Trapani, Bruna Lavezzo, Alberto Zanetto, Francesca D'Arcangelo, Manuela Merli, Lucia Lapenna, Federica Invernizzi, Gloria Taliani, Patrizia Burra
Summary: Alcohol-related liver disease (ArLD) is a leading cause of chronic liver disease worldwide. The sex gap in ArLD is narrowing due to increasing alcohol consumption among women, who are more vulnerable to its harmful effects. Women have a higher risk of cirrhosis and liver-related mortality compared to men. This review summarizes the current knowledge on sex differences in alcohol metabolism, ArLD pathogenesis, disease progression, liver transplant indications, and pharmacological treatments, emphasizing the importance of a sex-specific management approach.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Review
Medicine, General & Internal
Rakesh Kumar Jagdish, Akash Roy, Karan Kumar, Madhumita Premkumar, Mithun Sharma, Padaki Nagaraja Rao, Duvvur Nageshwar Reddy, Anand V. Kulkarni
Summary: Cirrhosis progresses from compensation to decompensation driven by the severity of portal hypertension, leading to various complications. The severity of portal hypertension also contributes to advanced complications such as hyperdynamic circulation and hepatorenal syndrome. The management of these complications has undergone significant developments. Acute-on-chronic failure (ACLF) is a rapidly worsening condition with high mortality, but early intervention can improve outcomes. This review focuses on complications of portal hypertension and approaches to managing ACLF.
FRONTIERS IN MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Alberto Zanetto, Valentina Cossiga, Sarah Shalaby, Maria Guarino, Federica Invernizzi, Lucia Lapenna, Chiara Becchetti, Filomena Morisco, Maria Cristina Morelli, Manuela Merli, Pierluigi Toniutto, Patrizia Burra
Summary: This narrative review, prepared by the Special Interest Group (SIG) Gender in Hepatology of the Italian Association for the Study of the Liver (AISF), aimed to review the current knowledge on the potential role of biological sex in vascular liver diseases. The review focused on diseases such as splanchnic vein thrombosis, hepatic vein thrombosis, porto-sinusoidal vascular disorder, and hereditary hemorrhagic telangiectasia. It also included a specific section on the management of pregnancy in young patients with these challenging diseases.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Adhara Lazaro, Patrick Stoll, Dominik von Elverfeldt, Wolfgang Kreisel, Peter Deibert
Summary: This study investigated the potential correlation between mean arterial pressure (MAP) and portal venous pressure (PVP) in rats with healthy livers. The results showed that changes in MAP are followed by changes in PVP with a distinct time lag, indicating a cause-and-effect relationship. The study also revealed that Sildenafil influences portal pressure. Further studies should be conducted in a model with cirrhotic livers to evaluate the effects of vasoactive drugs for therapy of portal hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Dominique Thabut, Masatoshi Kudo
Summary: Portal hypertension and hepatocellular carcinoma commonly coexist and their association affects the prognosis of cirrhosis patients. The interplay between these conditions has therapeutic significance in terms of treating HCC and managing PHT complications. The management recommendations for PHT have been revised, with new screening and prophylaxis indications. PHT may limit locoregional therapies and TIPS placement can be considered for HCC patients. New systemic HCC therapies can impact PHT levels and increase the risk of bleeding. Prevention and adequate treatment of PHT complications are important, particularly in advanced HCC cases. This expert opinion discusses specific aspects of managing both conditions, incorporating recent data in the HCC field.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Fanny Turon, Ellen G. Driever, Anna Baiges, Eira Cerda, Angeles Garcia-Criado, Rosa Gilabert, Concepcio Bru, Annalisa Berzigotti, Isabel Nunez, Lara Orts, Juan Carlos Reverter, Marta Magaz, Genis Camprecios, Pol Olivas, Fabian Betancourt-Sanchez, Valeria Perez-Campuzano, Annabel Blasi, Susana Seijo, Enric Reverter, Jaume Bosch, Roger Borras, Virginia Hernandez-Gea, Ton Lisman, Juan Carlos Garcia-Pagan
Summary: In patients with cirrhosis, the main predictive factors for portal vein thrombosis (PVT) development are related to the severity of portal hypertension. There is no significant relationship between PVT development and other clinical, biochemical, inflammatory, and acquired or hereditary hemostatic parameters.
JOURNAL OF HEPATOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
E. Llop, J. L. Calleja
Summary: This article is linked to papers by Paternostro et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Hongqun Liu, Henry H. Nguyen, Sang Youn Hwang, Samuel S. Lee
Summary: Patients with portal hypertension may develop various complications, including cardiovascular abnormalities. Oxidative stress is believed to play a crucial role in the pathogenesis of these complications, and blocking oxidative stress could potentially alleviate the severity of cardiovascular diseases associated with portal hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)