Article
Medical Laboratory Technology
Mukulika Bose, Alexa Sanders, Chandrav De, Ru Zhou, Priyanka Lala, Sophia Shwartz, Bhaskar Mitra, Cory Brouwer, Pinku Mukherjee
Summary: Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDA), is a major cause of cancer-related deaths in the United States. Surgical resection is the best treatment option, but only a small percentage of patients are eligible. Recurrence and metastasis are the main reasons for mortality. A monoclonal antibody named TAB004 has been developed to target tumor-associated MUC1 (tMUC1), which is expressed in over 80% of PDAs. Treatment with TAB004 has shown significant effects in reducing colony-forming potential in PDA cells and inducing cell death. The mechanism involves disruption of cellular integrity, activation of ER stress and anoikis, and inhibition of oncogenic signaling pathways. TAB004 also exhibited promising results in mouse models, indicating its potential as a prophylactic agent to prevent tumor relapse, metastasis, and increase the efficacy of chemotherapy.
TRANSLATIONAL RESEARCH
(2023)
Editorial Material
Biology
Xinming Xu, Antony N. Dodd
Summary: This study reveals that the circadian clock in Arabidopsis plants affects the rhythmicity of rhizosphere microbial communities, raising the question of bidirectional rhythmic interaction between plants and their rhizomicrobiomes. The findings also suggest that soil microbiomes can have both self-sustained and plant-imposed rhythmicity.
Review
Gastroenterology & Hepatology
Paula Cantallops Vila, Aashreya Ravichandra, Alona Agirre Lizaso, Maria J. Perugorria, Silvia Affo
Summary: Cholangiocarcinoma (CCA) is a type of biliary tree tumor with late diagnosis, low survival rate, and resistance to chemotherapy. CCA can be classified based on anatomical location and has molecular subclasses with heterogeneity. Besides tumor cells, CCA also has a complex tumor microenvironment where tumor cells interact with stromal cells. Cancer-associated fibroblasts (CAFs), a major component of the tumor stroma, play a role in tumor development by influencing various aspects of the disease. Recent evidence suggests the presence of heterogeneous CAF subtypes with both tumor-promoting and tumor-restricting properties. This review discusses the origin, heterogeneity, crosstalk, and potential therapeutic targeting of CAFs in CCA.
Article
Microbiology
Akansha Jain, Harikesh Bahadur Singh, Sampa Das
Summary: Proteomic approaches provide insights into interactions between plants and microorganisms, with a focus on pathogenicity, stress responses, and antioxidant mechanisms. Fine regulation of protein expression is crucial for effective pathogen recognition and induction of resistance. Further research is needed to fully understand molecular plant-microbe interactions.
MICROBIOLOGICAL RESEARCH
(2021)
Review
Cell Biology
Cameron Jackson Bosveld, Colin Guth, Nathachit Limjunyawong, Priyanka Pundir
Summary: The interaction between skin microbiome and mast cells is crucial for maintaining skin health and has significant implications for the occurrence of skin diseases.
Article
Gastroenterology & Hepatology
Mengjia Song, Junyi He, Qiu-Zhong Pan, Jieying Yang, Jingjing Zhao, Yao-Jun Zhang, Yue Huang, Yan Tang, Qijing Wang, Jia He, Jiamei Gu, Yongqiang Li, Shiping Chen, Jianxiong Zeng, Zi-Qi Zhou, Chaopin Yang, Yulong Han, Hao Chen, Tong Xiang, De-Sheng Weng, Jian-Chuan Xia
Summary: This study revealed a cytokine-mediated cellular crosstalk and clinical network involving the CLCF1-CXCL6/TGF-beta axis, which regulates the positive feedback loop among CAFs, tumor stemness, and TANs, HCC progression, and patient prognosis. The up-regulation of the CLCF1-CXCL6/TGF-beta axis in clinical samples showed a correlation with increased cancer stem cells, N2-polarized TANs, tumor stage, and poor prognosis. This suggests the CLCF1 cascade could be a potential prognostic biomarker and targeting CLCF1/ ciliary neurotrophic factor receptor or ERK1/2 signaling could provide an effective therapeutic target for patients with HCC.
Review
Biochemistry & Molecular Biology
Zhifeng Li, Dazhuang Yang, Ting Guo, Mei Lin
Summary: Breast cancer is the leading cause of death among women with malignant tumors. Overexpression and aberrant glycosylation of MUC1 have been found to be closely associated with breast cancer, making it an ideal target for immunotherapy. This review summarizes the research achievements of MUC1-mediated immunotherapy for breast cancer from laboratory to clinic, and predicts future directions.
Review
Oncology
Farnaz Khodabakhsh, Parnaz Merikhian, Mohammad Reza Eisavand, Leila Farahmand
Summary: VEGF and its receptor family play significant roles in pathological processes such as angiogenesis in tumor growth and metastasis. Overexpression of MUC1 on tumor cells leads to upregulation of various signaling pathways related to growth and survival.
CANCER CELL INTERNATIONAL
(2021)
Review
Nutrition & Dietetics
Inah Gu, Emory Gregory, Casey Atwood, Sun-Ok Lee, Young Hye Song
Summary: Cancer metabolism is complex, with metabolites such as vitamins, lactate, and amino acids playing important roles in cancer-nerve crosstalk. Therefore, studying the role of nutrients in cancer-nerve crosstalk can provide a comprehensive understanding of tumor mechanisms and potentially identify targets for future cancer therapies.
Review
Oncology
Yutaka Naito, Yusuke Yoshioka, Takahiro Ochiya
Summary: Intercellular communication plays a crucial role in cancer initiation and progression, with cancer-associated fibroblasts (CAFs) being a key component in this process. Recent research on extracellular vesicles (EVs) as regulators of intercellular communication has shown significant advancements. EVs facilitate the transfer of functional molecules to recipient cells, influencing the communication between cancer cells and CAFs and promoting cancer progression.
CANCER CELL INTERNATIONAL
(2022)
Review
Fisheries
Yong-Yao Yu, Li-Guo Ding, Zhen-Yu Huang, Hao-Yue Xu, Zhen Xu
Summary: Fish harbor a complex and dynamic microbiota on their mucosal surfaces, with a normal microbiota contributing to fish health and disruptions potentially leading to disease. Fish have developed immune mechanisms to distinguish between beneficial and opportunistic bacteria. Probiotics have been effectively used in aquaculture for disease prevention.
REVIEWS IN AQUACULTURE
(2021)
Article
Gastroenterology & Hepatology
Renyuan Gao, Chunyan Wu, Yefei Zhu, Cheng Kong, Yin Zhu, Yaohui Gao, Xiaohui Zhang, Rong Yang, Hui Zhong, Xiao Xiong, Chunqiu Chen, Qian Xu, Huanlong Qin
Summary: This study identified microbial and metabolic signatures of colorectal cancer (CRC) with broad population relevance, developed a diagnostic panel for CRC and adenoma, and linked many CRC-associated metabolites with gut microbiome signatures of the disease, providing new insights for exploring CRC-related features.
Review
Immunology
Wenxia Zhu, Yilin Wu, Hui Liu, Caini Jiang, Lili Huo
Summary: The gut microbiota plays a crucial role in maintaining the organ microenvironment and can be considered in preventing and treating respiratory diseases. However, studies on the interaction between children's intestinal flora and respiratory infections are still lacking.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Plant Sciences
Marco Giovannetti, Alessandra Salvioli di Fossalunga, Ioannis A. Stringlis, Silvia Proietti, Valentina Fiorilli
Summary: Soil is essential for life and biodiversity on Earth. Preserving soil quality is crucial for ecological balance, food production, and human health. Soil fertility assessment has evolved from crop performance to analyzing physico-chemical parameters, and now includes biological parameters. Finding predictive and easy-to-measure indexes for evaluating soil quality is a challenge, but using plant health traits can be a powerful way to assess soil properties.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Medicine, Research & Experimental
Fariba Maleki, Farzaneh Rezazadeh, Kambiz Varmira
Summary: MUC1 is a large, transmembrane mucin glycoprotein overexpressed in most adenocarcinomas, playing a significant role in tumor progression with distinct features from MUC1 in normal cells. Targeting MUC1 for cancer immunotherapy and imaging exploits the differences between cancerous and normal cells. Radiopharmaceuticals have the potential use as carriers for delivering radionuclides to tumors for diagnostic imaging and radiotherapy, with several radiolabeled targeting molecules efficiently detecting and treating cancer by targeting MUC1.
MOLECULAR PHARMACEUTICS
(2021)
Review
Cell Biology
Mukulika Bose, Pinku Mukherjee
MEDIATORS OF INFLAMMATION
(2019)
Article
Cell Biology
Mahboubeh Yazdanifar, Ru Zhou, Priyanka Grover, Chandra Williams, Mukulika Bose, Laura J. Moore, Shu-ta Wu, John Maher, Didier Dreau, Pinku Mukherjee
Article
Biochemistry & Molecular Biology
Mahnaz Sahraei, Mukulika Bose, J. Alexa Sanders, Chandrav De, Lopamudra DasRoy, Sritama Nath, Cory R. Brouwer, Pinku Mukherjee
Summary: The study revealed accelerated tumor growth in MUC1KO mice, associated with increased suppressive MDSCs and Tregs in the tumor microenvironment. MUC1KO host showed elevated levels of iNOS, ARG1, and TGF-beta, promoting proliferation of MDSCs with an immature and immune suppressive phenotype. Additionally, MDSCs from MUC1KO mice exhibited higher c-Myc and activated pSTAT3 levels, suggesting increased survival, proliferation, and prevention of maturation of MDSCs in the MUC1KO host.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Mukulika Bose, Priyanka Grover, Alexa J. Sanders, Ru Zhou, Mohammad Ahmad, Sophia Shwartz, Priyanka Lala, Sritama Nath, Mahboubeh Yazdanifar, Cory Brouwer, Pinku Mukherjee
Summary: This study finds that MUC1 plays a significant role in the development of pancreatic ductal adenocarcinoma (PDA). Overexpression of MUC1 activates the JNK pathway and increases cell viability. Conversely, low expression of MUC1 allows TGF-beta to retain its tumor-suppressive function. These findings contribute to a better understanding of the mechanisms behind PDA development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medical Laboratory Technology
Mukulika Bose, Alexa Sanders, Chandrav De, Ru Zhou, Priyanka Lala, Sophia Shwartz, Bhaskar Mitra, Cory Brouwer, Pinku Mukherjee
Summary: Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDA), is a major cause of cancer-related deaths in the United States. Surgical resection is the best treatment option, but only a small percentage of patients are eligible. Recurrence and metastasis are the main reasons for mortality. A monoclonal antibody named TAB004 has been developed to target tumor-associated MUC1 (tMUC1), which is expressed in over 80% of PDAs. Treatment with TAB004 has shown significant effects in reducing colony-forming potential in PDA cells and inducing cell death. The mechanism involves disruption of cellular integrity, activation of ER stress and anoikis, and inhibition of oncogenic signaling pathways. TAB004 also exhibited promising results in mouse models, indicating its potential as a prophylactic agent to prevent tumor relapse, metastasis, and increase the efficacy of chemotherapy.
TRANSLATIONAL RESEARCH
(2023)
Review
Physiology
Mukulika Bose, Bhaskar Mitra, Pinku Mukherjee
Summary: The COVID-19 pandemic has had a devastating impact on global health and economy. Studying mucins and their connection to pathogenicity may lead to the development of a biomarker for predicting susceptibility, progression, and therapy response in COVID-19 patients.
PHYSIOLOGICAL REPORTS
(2021)
Meeting Abstract
Oncology
Mukulika Bose, Aabha Vora, Taylor Colleton, Pinku Mukherjee
Review
Immunology
Mukulika Bose, Pinku Mukherjee
Meeting Abstract
Oncology
Mukulika Bose, Pinku Mukherjee
