Article
Chemistry, Physical
Parvathy O. Chandrasekaran, Ajayakumar Aswathy, Kiran James, Kannankutty Kala, Mohanan T. Ragi, Narayanapillai Manoj
Summary: In this study, a molecular chameleon with D-pi-A architecture, PRAA, was synthesized and utilized as a fluorescent sensor for toxic metal ions. Its selectivity towards Ag+, Hg2+, and Pb2+ ions can be adjusted by solvent polarity. The mechanism of binding and stoichiometry of interaction were established through experimental and theoretical methods. PRAA's potential as a probe for detecting Ag+ and Hg2+ ions in aqueous solutions using an anionic surfactant medium was convincingly demonstrated.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Linlin Yang, Nan Yang, Pengli Gu, Yihua Zhang, Xianyu Gong, Shichao Zhang, Junwan Li, Liguo Ji, Guangjie He
Summary: A novel ratiometric fluorescent probe (NG-TCF) based on ICT mechanism was developed for monitoring SO2 derivatives. The probe showed fast response rate, good sensitivity, and specific response, making it suitable for imaging SO2 derivatives in living cells.
BIOORGANIC CHEMISTRY
(2022)
Article
Spectroscopy
Liangyu He, Qi Li, Yaqing Zhang, Kun Huang, Bingxin Du, Lijuan Liang
Summary: A naphthalimide functionalized fluoran dye NAF has been prepared, which exhibits a red-shift in emission at 550 nm in a water-CH3CN mixture due to aggregating induced emission (AIE) effect. NAF can function as a selective and sensitive sensor for Hg2+ ions by displaying a ratiometric fluorescence signal change and visible color change. It shows fast response time, wide pH range, and low detection limit, making it suitable for ratiometric imaging of Hg2+ ions in living HeLa cells.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Sumita Subedi, Lok Nath Neupane, Hyeongseok Yu, Keun-Hyeung Lee
Summary: A highly selective ratiometric fluorescent chemodosimeter was synthesized for the detection of Hg2+, which showed remarkable detection properties including high selectivity and sensitivity, large fluorescent signal changes, and well-operation in aqueous solutions. The displacement reaction between phenylboronic acid and Hg2+ ions provided a covalent adduct of mercury ion, leading to significant fluorescent signal changes when aggregated in aqueous solution. With a low detection limit of 15.2 nM, nanomolar concentrations of Hg2+ could be successfully detected, providing a ratiometric fluorescent detection method for quantifying low levels of Hg2+ in groundwater and tap water samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Polymer Science
Yanan Zhang, Dajun Hou, Zelong Wang, Ning Cai, Chaktong Au
Summary: This review systematically summarizes the recent progress in nanomaterial-based dual-emission ratiometric fluorescent biosensors, which play an essential role in biosensing and cell imaging applications. It introduces general design approaches and typical examples, while also discussing potential challenges and future outlook for dual-emission ratiometric fluorescent nanosensors.
Article
Chemistry, Analytical
Shuchen Pei, Chaozheng Li, Xinyu Pei, Xiangyang Zhang, Yuting Chi, Wenhong Zeng, Yuanyuan Zhang, Xiaoling Liao, Jun Chen
Summary: The high biological toxicity of mercury ion (Hg2+) has had a negative impact on society, necessitating the development of a rapid Hg2+ detection method. In this study, two fluorescent probes, YF-Hg and YF-Cl-Hg, were developed. YF-Cl-Hg, with an electron-withdrawing substituent (-Cl), exhibited a larger Stokes shift and a more pronounced UV-vis absorption redshift compared to YF-Hg in a pH = 7.4 environment. The reasons for the superior spectral performance of YF-Cl-Hg were explored using density functional theory (DFT) calculations and UV-vis absorption spectroscopy. Furthermore, the good biocompatibility of YF-Cl-Hg suggests its potential as a tool for Hg2+ detection in cells.
ANALYTICAL METHODS
(2023)
Article
Spectroscopy
Yuzhu Zhai, Yijing Li, Xiaoke Huang, Juying Hou, Houshen Li, Shiyun Ai
Summary: A colorimetric and ratiometric fluorescent dual-mode assay based on UiO-66-NH2@Au was constructed for sensitive and specific detection of Hg2+. The assay utilized the peroxidase-like activity of UiO-66-NH2@Au stimulated by the addition of Hg2+, leading to changes in colorimetric and fluorescent signals. The assay demonstrated linear correlation with Hg2+ concentration and was successfully applied to the determination of Hg2+ in tap water and river water.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Materials Science, Multidisciplinary
Xiaohua Yang, Wenjing He, Mingyu Gan, Shaomin Shuang, Martin M. F. Choi, Wei Bian
Summary: In this study, a dual response ratiometric fluorescent probe was constructed for the rapid, on-site, sensitive, and selective detection of tetracycline (TC). The probe was synthesized by mixing sodium citrate (CitNa), europium ion (Eu3+), and sulfur and oxygen co-doped graphite phase carbon nitride quantum dots (S,O-C(3)N(4)QDs) solution in a specific proportion. The probe exhibited a significant decrease in blue fluorescence (lambda(em) = 445 nm) and an increase in red fluorescence (lambda(em) = 620 nm) in the presence of TC, allowing for ultra-sensitive detection from 0.25 to 120 μM, with a detection limit of 1.3 nM. A smartphone app monitoring platform based on test paper was also developed, demonstrating the potential application of the ratiometric fluorescent probe in medical and environmental fields.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Guangjie Song, Di Jiang, Lei Wang, Xiangzhong Sun, Hongtian Liu, Yanqing Tian, Meiwan Chen
Summary: In this study, a simple fluorescent dye called BFCUR was developed for pH sensing. By deprotonating the phenolic hydroxyl groups, BFCUR exhibited significant red-shift and enhanced fluorescence emission, allowing for ratiometric pH detection and visual pH detection using test strips. BFCUR also showed low cytotoxicity and was successfully applied for intracellular pH detection. The findings highlight the great potential of CUR-derived BFCUR as colorimetric and fluorescent probes for ratiometric pH sensing and cell imaging.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Analytical
Shaobing Zhang, Haidong Yan, Hongni Li, Tiantian Xu, Hui Li, Chengkun Wang, Zheng Yang, Xiaodan Jia, Xiangrong Liu
Summary: Nitrogen-doped carbon dots (NCDs) were synthesized using coal washing wastewater as the carbon source, tryptophan for nitrogen doping, and surface functionalization with polyethylene glycol. The NCDs exhibited excellent fluorescent properties and could be used as fluorescent ink for message encryption, as well as fluorescent sensors for Hg2+ and GSH detection in various forms. The NCDs also showed low cytotoxicity and good biocompatibility, making them suitable for imaging Hg2+ and GSH in living cells. This study demonstrates the potential applications of NCDs in anti-counterfeiting, message encryption, and environmental/biological sensing.
Article
Chemistry, Multidisciplinary
Dan Chang, Zhonghua Zhao, Wenyan Li, Hu Shi, Yongxing Yang, Lihong Shi, Shaomin Shuang
Summary: A novel ratiometric fluorescent probe was designed to distinguish glutathione (GSH) from structurally similar substances, providing a potential for rapid detection and imaging in physiological and pathological processes, with high application potential.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Huifang Li, Yiru Tang, Kunrong Shen, Ji Lu, Zhijie Zhang, Dong Yi, Na Hao, Qiang Fu, Zi Ye, Jun Wei, Jun Wang, Xianchao Pan, Siping Wei, Lin Yang
Summary: Four benzoindolenine-based squaraine dyes with intense visible and near-infrared absorption and emission were synthesized and characterized. Among them, BBSQ showed excellent performance, exhibiting high selectivity to Fe3+, Cu2+, and Hg2+ in acetonitrile solution even in the presence of other competitive metal ions, easily detected by the naked eye. The detection limit was 14.17 μM for Fe3+ and 6.06 μM for Cu2+. BBSQ's response mechanism to Fe3+, Cu2+, and Hg2+ involves the coordination of BBSQ and metal ions through specific atoms. BBSQ was also successfully applied to detect Fe3+, Cu2+, and Hg2+ in thin-layer chromatography plates.
Article
Biochemistry & Molecular Biology
Daili Liu, Gaofei Chen, Guiqian Fang
Summary: NCR is a near-infrared fluorescent sensor capable of detecting H2O2 and viscosity with high sensitivity. It has the potential to be a practical tool for monitoring H2O2 level in biological processes, and has been successfully used to detect exogenous and endogenous H2O2 in living cells.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Xiaohang Xu, Qian Zhang, Haichang Ding, Gang Liu, Shouzhi Pu
Summary: A novel FRET-based ratiometric fluorescent probe, Ro1, composed of rhodamine and naphthalimide groups, was synthesized and found to exhibit high selectivity and sensitivity to Hg2+. The probe enabled naked-eye detection of Hg2+ through a significant color change from yellow to pink. The rapid response time of Ro1 to Hg2+ within 60 s and its low limit of detection (0.75 mu M) were also demonstrated. Mechanistic studies using 1H NMR, ESI-MS, and HPLC spectra were conducted to understand the detection mechanism of probe Ro1 for Hg2+. Additionally, Ro1 was developed as a molecular keypad lock with different sequences of Hg2+ and Cu(2+) chemical input. Fluorescence imaging experiments in living Hela cells further demonstrated the potential applications of Ro1 in biological systems.
INORGANICA CHIMICA ACTA
(2022)
Article
Spectroscopy
Xiong Chen, Detao Jiang, Chen Jiang, Cheng Yao
Summary: In this study, phenothiazine was chosen as a fluorophore to construct a NIR fluorescent probe PMM for monitoring the level of hypochlorous acid (HOCl) in lysosomes. PMM is a colorimetric and ratiometric fluorescent probe with high sensitivity, low detection limit, high selectivity, and anti-interference. It has been successfully used for fluorescence imaging of exogenous and endogenous HOCl in HepG2 cells, as well as in vivo detection in nude mice.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
