Article
Engineering, Environmental
Qin-Ying Li, Liyun Ma, Li Li, Shilin Wang, Xi Li, Cong Zhang, Yu Zhang, Ming Jiang, Hui Wang, Kun Huang, Xu Yu, Li Xu
Summary: A novel dual-element sensor array based on carbon nanodots (CDs) doped with different oxidants was constructed for accurate discrimination of disease-related proteins, quantification, and monitoring of fibrillation stages. The sensor array showed potential for fast screening of cancer patients and healthy individuals based on serum samples at mu L-level, demonstrating its powerful application in biomedical research and disease diagnosis.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Green & Sustainable Science & Technology
Evie L. Papadopoulou, Giulia Biffi, Anitha Senthamizhan, Beatriz Martin-Garcia, Riccardo Carzino, Roman Krahne, Athanassia Athanassiou
Summary: The paper sensor is designed to detect nanomaterials using fluorescence changes of carbon nanodots, allowing for selective detection of different nanomaterials based on their unique photoluminescence quenching mechanisms. The sensor enables easy detection of nanomaterials under UV light and can detect them through direct contact with their dispersions or powders, providing a straightforward method for practical applications.
Article
Chemistry, Analytical
Na Du, Manling Chen, Yunmiao Cui, Xue Liu, Yang Li
Summary: The carbon nanodot sensor array can accurately identify and quantitatively analyze multiple organic acids in urine samples with high selectivity and sensitivity. It can achieve the quantitative analysis of single organic acid systems or dual organic acid systems, making it an effective method for OA analysis.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Mo Xie, Linjie Guo, Shu Xing, Shuting Cao, Ziwei Zhao, Kaiyi Liang, Jiang Li, Shihua Luo, Yu Zhang, Lianhui Wang
Summary: By utilizing the programmability of fractal DNA frameworks, multi-color probes were constructed by arranging fluorescent molecules and nucleic acid aptamers on the structure. Multiplexed cell imaging and classification was achieved through pattern recognition.
CHEMICAL COMMUNICATIONS
(2021)
Article
Spectroscopy
Baraa R. Al-Hashimi, Khalid M. Omer, Heshu S. Rahman, Hemn H. Othman
Summary: A sensitive and selective inner filter effect sensing platform was designed to detect nitrofurantoin in pharmaceutical dosage form using nitrogen and phosphorus co-doped carbon nanodots. The prepared CNDs exhibited greenish fluorescence with high stability and sensitivity for pharmaceutical applications. The fluorometric assay successfully determined NIT in capsules with comparable results to a reference method, while sub-acute toxicity studies in mice showed no signs of toxicity related to CNDs consumption.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Pharmacology & Pharmacy
Taotao Huo, Wenshuai Li, Dong Liang, Rongqin Huang
Summary: This study successfully achieved high enrichment of tumor cells by preparing tumor cell-derived carbon nanodots and utilized their specific binding ability to achieve tumor-specific fluorescence imaging. This research provides new insights and methods for tumor diagnosis.
Article
Biochemistry & Molecular Biology
Angelo Nicosia, Placido Mineo, Norberto Micali, Valentina Villari
Summary: The development of biocompatible composites using polydopamine and fluorescent carbon dots shows promise in exploiting the adhesive properties of polydopamine for various technologies. The catechol unit of dopamine plays a key role in the formation of the supramolecular complex, where the fluorescence emission of carbon nanodots is quenched by photoinduced electron transfer. Interaction with the basic surface sites of the nanodots leads to dopamine oxidation and its oligomerization/polymerization on the nanodot surface.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Mengli Yang, Cui Liu, Ying Peng, Ru-Zhen Xiao, Song Zhang, Zhi-Ling Zhang, Bing Zhang, Dai-Wen Pang
Summary: Fluorescence quenching of carbon nanodots by metal ions has been widely used for the determination of various substances. The specific recognition of carbon nanodots to Hg2+ is achieved by controlling the surface structure and passivating certain functional groups. This work enables the rational design of carbon nanodots for improved selective recognition abilities.
ANALYTICA CHIMICA ACTA
(2021)
Article
Spectroscopy
Anqi Hu, Guoqing Chen, Taiqun Yang, Chaoqun Ma, Lei Li, Hui Gao, Jiao Gu, Chun Zhu, Yamin Wu, Xiaolin Li, Yitao Wei, Anlan Huang, Xiaoqian Qiu, Jinzeng Xu, Jialu Shen, Lvyuan Zhong
Summary: In this study, a sensitive fluorescent probe was reported for the detection of thiourea in soil, wastewater, and fruits. The probe utilized fluorescent carbon nanodots and gold nanoparticles based on the fluorescence resonance energy transfer effect, and showed excellent selectivity and sensitivity for thiourea.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Spectroscopy
Qi Wang, Ziru Zhang, Tian Yang, Yejiao Han, Ying Cheng, Jiana Wu, Jingjing Bai, Chunlei Ma, Yulan Niu, Shaomin Shuang
Summary: Carbon nanodots (CNDs) were synthesized through a facile method and combined with MnO2 nanoparticles for captopril detection. The sensor achieved sensitive and selective detection of captopril through fluorescence quenching and recovery effects, showing practical value.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Physical
Zhenzhen Guo, Jinwen Zhu, Jian Yin, Peng Miao
Summary: A novel fluorescent biosensor based on Zeolitic Imidazolate Framework-8 (ZIF-8) nanocomposites is developed for the detection of H2O2 and glucose. The AgNP-CD-ZIF-8 nanocomposites serve as a highly sensitive platform for the analysis of H2O2. This turn-on biosensor can be used for facile and convenient quantification of H2O2 and further extended to detect glucose in real samples.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemical Research Methods
Manling Chen, Xue Liu
Summary: In this study, CD sensors were designed against Cu(II) and Ag(I) using appropriate carbon sources, showing responses to both metal ions. The response sensitivity was found to correspond to the binding energy between the carbon source and metal ions, which is crucial for further design of CD sensors for various analytes. These findings provide valuable insights for the development of CD sensors with improved selectivity.
JOURNAL OF FLUORESCENCE
(2021)
Article
Chemistry, Physical
Valentina Villari, Massimiliano Gaeta, Alessandro D'Urso, Norberto Micali
Summary: The functionalization of carbon dots with dyes through supramolecular interactions can provide desired optical properties. In this study, supramolecular complexes formed spontaneously in water medium between an anionic meso-tetrakis(4-sulfonatophenyl) porphyrin and three different fluorescent carbon nanodots were investigated. The results showed that the formation of porphyrin/carbon dot adducts is favored by high surface charge of the nanodots, and the resulting emission properties depend on the surface precursor. These nanomaterials show fluorescence quenching, making them potential candidates for energy conversion or sensor applications.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Analytical
Lu Chen, Minxia Song, Jie Guan, Yun Shu, Dangqin Jin, Gaochao Fan, Qin Xu, Xiao-Ya Hu
Summary: The study introduced carbon nanodots and polyvinylidene fluoride as additives into perovskite to prepare a composite with improved water tolerance and mechanical stability, which was applied in photoelectrochemical sensing for cholesterol detection with a detection limit lower than most methods. This platform may have potential applications for other analytes and could contribute to enhancing the performance of organic-inorganic perovskites.
Article
Chemistry, Multidisciplinary
Yuying Liu, Jiao Chen, Zijun Xu, Hao Liu, Tingting Yuan, Xiyuan Wang, Jianjie Wei, Qingdong Shi
Summary: This study presents a fluorescence sensor array based on carbon quantum dots for detecting heavy metal ions in environmental samples. The sensor array demonstrates high accuracy in detecting multiple metal ions, and the SX-model helps improve the performance through machine learning. The method shows great potential for environmental monitoring of heavy metal pollution.
ENVIRONMENTAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).