Journal
SYNTHESIS-STUTTGART
Volume 52, Issue 2, Pages 311-319Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0039-1690717
Keywords
nickel; cross-coupling; scalable; heterocycles
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Funding
- University of Toronto (UofT)
- Natural Science and Engineering Research Council (NSERC)
- Alphora Research Inc.
- Kennarshore Inc.
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A Ni-catalyzed C-S cross-coupling using only NiI2 (0.5-2.5 mol%) and P(OiPr)(3) (2.0-10.0 mol%) is reported. Using an air-stable Ni(II) precatalyst, and a cheap and commercially available ligand, a scalable and robust method was developed to cross-couple various thiophenols and styryl bromides, including some sterically encumbered thiols, an alpha-bromocinnamaldehyde as well as a thiolation-cyclization.
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