Review
Neurosciences
Marina Zettin, Caterina Bondesan, Giulia Nada, Matteo Varini, Danilo Dimitri
Summary: Aphasia is a language disorder caused by brain damage, and tDCS has been proven effective in promoting successful recovery in both short and long term treatment, especially when combined with other language and communication therapies. The success of tDCS depends on factors such as electrode placement, stimulation duration, and brain tissue characteristics, making it a promising tool for rehabilitating patients with aphasia.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Review
Geriatrics & Gerontology
Silke Coemans, Esli Struys, Dorien Vandenborre, Ineke Wilssens, Sebastiaan Engelborghs, Philippe Paquier, Kyrana Tsapkini, Stefanie Keulen
Summary: Various tDCS approaches have been used to explore the potential of tDCS in improving language outcomes or slowing down the decline of language competences in PPA cases. While the stimulation protocols and study designs in PPA are similar to post-stroke aphasic populations, differences in pathophysiology require further investigation to establish the optimal stimulation paradigm. Despite heterogeneity in patient populations, stimulation protocols, and study design, tDCS is considered an effective tool for improving language outcomes.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Melissa D. Stockbridge, Jordan Elm, Bonnie L. Breining, Donna C. Tippett, Rajani Sebastian, Christy Cassarly, Abeba Teklehaimanot, Leigh Ann Spell, Shannon M. Sheppard, Emilia Vitti, Kristina Ruch, Emily B. Goldberg, Catherine Kelly, Lynsey M. Keator, Julius Fridriksson, Argye E. Hillis
Summary: This study investigated the efficacy of transcranial direct-current stimulation (tDCS) as an adjunct therapy for chronic aphasia. The results showed that tDCS did not significantly improve patients' naming accuracy, but did enhance their discourse skills.
Article
Clinical Neurology
Shereen J. Matar, Caroline Newton, Isaac O. Sorinola, Marousa Pavlou
Summary: This study aimed to determine the feasibility of anodal tDCS as an adjunct to VNeST to improve discourse production in post-stroke chronic aphasia. The results showed promising changes in discourse production measures and functional communication for the active tDCS group. This suggests that tDCS may be a safe and economical tool for enhancing rehabilitation in chronic aphasia.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Seong Hoon Bae, Seo Jin Moon, Jeong Gum Lee, Yun Kyung Yim, Hee So Oh, Dong Hee Han, In Seok Moon
Summary: The study compared the effects of rTMS and tDCS treatments for chronic tinnitus, showing comparable results in reducing tinnitus symptoms, with tDCS possibly being more cost-effective.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Sinan Yasaroglu, Joachim Liepert
Summary: This study aimed to characterize the changes in motor excitability and motor performance induced by a single session of anodal and cathodal transcranial direct current stimulation (tDCS) in stroke patients. The results showed that anodal tDCS significantly reduced short interval intracortical inhibition (SICI) without affecting intracortical facilitation (ICF) or long interval intracortical inhibition (LICI). Cathodal tDCS did not change motor excitability. Both types of tDCS did not alter motor performance. The SICI in the affected hemisphere was lower than in the unaffected hemisphere even before anodal tDCS, and it was correlated with changes in motor performance after anodal tDCS.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Qi Zhao, Jing Wang, Zheng Li, Luping Song, Xiaoli Li
Summary: The study evaluated the effects of tDCS combined with speech language therapy on nonfluent poststroke aphasia patients. After tDCS treatment, the AQ mean in the A-tDCS group was significantly higher than in the S-tDCS group. Overall, the results suggest that left inferior gyrus frontalis anodic tDCS is an effective adjuvant to conventional speech language therapy for nonfluent PSA patients.
Article
Neurosciences
Milan Pantovic, Lidio Lima de Albuquerque, Sierra Mastrantonio, Austin S. Pomerantz, Erik W. Wilkins, Zachary A. Riley, Mark A. Guadagnoli, Brach Poston
Summary: Transcranial direct current stimulation (tDCS) applied to the primary motor cortex (M1) improves motor learning in relatively simple motor tasks performed with the hand and arm, but its effect on complex motor tasks involving whole-body coordination is unclear. This study found that tDCS applied over multiple days can improve motor learning in a complex overhand throwing task.
Review
Medicine, General & Internal
Claudia A. A. Salazar, Wuwei Feng, Leonardo Bonilha, Steven Kautz, Jens H. H. Jensen, Mark S. S. George, Nathan C. Rowland
Summary: During rehabilitation, transcranial direct current stimulation (tDCS) can be used to prime the motor system of stroke patients and potentially enhance therapy outcomes. However, the efficacy of tDCS varies among patients, which may be influenced by factors such as cortical infarct regions, motor tract injury, and connectivity changes. Neuroimaging techniques are needed to quantify these factors and understand the impact on tDCS delivery. This review summarizes the development of tDCS for stroke from a neuroimaging perspective and discusses potential strategies for personalized tDCS based on anatomy, connectivity, and brain activation dynamics.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Qi Zhou, Zhiwang Liu, Shengnan Zhao, Jia Yu, Dongsheng Zhou, Weiqian Xu, Yuanyuan Zhang
Summary: Long-term insomnia can have negative impacts on individuals' normal life and work, and increase the risk of various health problems. This study reported the case of a 52-year-old woman with chronic insomnia who received combined repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS). After the treatment, significant clinical improvement was observed, which lasted for one month after the intervention.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Neurosciences
Nicole R. Nissim, Denise Y. Harvey, Christopher Haslam, Leah Friedman, Pandurang Bharne, Geneva Litz, Jeffrey S. Phillips, Katheryn A. Q. Cousins, Sharon X. Xie, Murray Grossman, Roy H. Hamilton
Summary: This study found that cortical thickness and volume can serve as predictors of naming improvement in patients with primary progressive aphasia (PPA) undergoing high-definition transcranial direct current stimulation (HD-tDCS) therapy. Thicker frontal cortex was associated with immediate naming gains, while thickness of temporal areas predicted naming changes after 6 weeks. These findings suggest the involvement of a broader network of brain regions in the long-term maintenance of treatment effects. In addition, volume was associated with immediate naming performance in the sham condition, indicating the benefits of behavioral speech language therapy and the neural correlates of its short-lived treatment gains.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Integrative & Complementary Medicine
Samwel Sylvester Msigwa, Yan Li, Xiang-lin Cheng, Fen Cao
Summary: This study retrospectively analyzed the therapeutic consequences of combining electroacupuncture and transcranial direct current stimulation (tDCS) with speech and language therapy (SLT) in subacute post-stroke aphasia (PSA) patients. The results showed significant improvements in spontaneous conversation and naming ability in the acupuncture group, as well as improvement in word retrieval. Future clinical trials are needed to further validate the effectiveness of this treatment approach.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Review
Clinical Neurology
Giordano D'Urso, Elena Toscano, Annarita Barone, Mario Palermo, Bernardo Dell'Osso, Giorgio Di Lorenzo, Antonio Mantovani, Giovanni Martinotti, Michele Fornaro, Felice Iasevoli, Andrea de Bartolomeis
Summary: Despite multiple available treatments for bipolar depression, many patients do not respond well. Transcranial direct current stimulation (tDCS) has shown promise in treating resistant cases, although further research is needed to determine optimal dosing, timing, and safety considerations.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Leora R. Cherney, Edna M. Babbitt, Xue Wang, Laura L. Pitts
Summary: This study investigated the safety and efficacy of combining fMRI-guided tDCS with SLT for individuals with chronic nonfluent aphasia following stroke. Results showed that active tDCS led to greater improvements in functional language and cortical activation compared to sham, although evidence for the superiority of one polarity in inducing language recovery was mixed.
Article
Rehabilitation
Yan Gong, Xian-Ming Long, Ying Xu, Xiu-Ying Cai, Ming Ye
Summary: The study demonstrated that 1Hz rTMS combined with anodal tDCS stimulation protocol showed significant effects on motor function and cortex excitability in subacute stroke patients, making it a potential preferred rehabilitative strategy for motor recovery.
CLINICAL REHABILITATION
(2021)
