Journal
BIOSENSORS & BIOELECTRONICS
Volume 77, Issue -, Pages 499-504Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2015.10.011
Keywords
Arsenic (III); Aptasensor; Cysteamine-capped CdTe/ZnS core/shell quantum dots; De-aggregation assay
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Funding
- Isfahan University of Technology (IUT) Research Council
- Center of Excellence in Sensor and Green Chemistry
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A new approach for developing a fluorimetric aptasensor has been described and applied for determination of a highly toxic cation, As(III). In this method an aptamer was used to aggregate cationic cysteamine-stabilized CdTe/ZnS core/shell quantum dots, as a result fluorescence quenching was accrued. In the presence of As(III), the aptamer and As(III) make a complex, which prevents aggregation of the quantum dots. Thus, the fluorescence intensity of the quantum dots was enhanced upon the de-aggregation, which depends on the concentration of As(III). The fluorimetric assay has a very low detection limit of 1.3 pmol L-1 As(III) with a dynamic range of 1.0 x 10(-11) to 1.0 x 10(-6) mol L-1. The interference effect of a wide variety of cations and anions was investigated, and the obtained results confirm high selectivity of the aptasensor for As(III) detection. The present assay was successfully applied for the determination of As(III) in several water samples. (C) 2015 Elsevier B.V. All rights reserved.
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