Article
Chemistry, Analytical
Lu-Ying Wang, Jing-Shuai Chen, Xing-Pei Liu, Chang-Jie Mao, Bao-Kang Jin
Summary: In this paper, an ultrasensitive photoelectrochemical aptasensor based on amplified signal strategy and competitive mechanism for ochratoxin A (OTA) detection was developed. The prepared photoactive composite material (BiFeO3/Bi2S3) possessed excellent separation ability of photogenerated electron-hole pair and effectively inhibited the recombination of hole and pair, resulting in significantly enhanced photocurrent intensity. The amplified signal strategy was achieved by adding methylene blue (MB), which facilitated electron transfer and improved the photoelectric conversion efficiency. Under optimal conditions, the aptasensor exhibited a wide linear relationship range from 10^5 to 10^13 g/mL and a low detection limit of 0.0135 fg/mL (3s/S). Simultaneously, the proposed photoelectrochemical aptasensor also showed excellent accuracy, stability, precision, and selectivity.
Article
Chemistry, Analytical
Jun-Tao Cao, Xiao-Jing Liao, Yu-Ling Wang, Yan-Ming Liu
Summary: A novel photoelectrochemical aptasensor for lead ion detection was developed based on a CdSe quantum dots co-sensitized ZnO-CdS nanostructure and the specificity of aptamer, showing a linear response and good detection limit. The sensor can detect lead ions in environmental water samples with high selectivity.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Xiaoyan Yang, Rong Huang, Lulu Xiong, Feng Chen, Wei Sun, Ling Yu
Summary: A novel colorimetric aptasensor was developed to detect ochratoxin A (OTA) by utilizing charge effect-assisted silver enhancement. Gold nanoparticles (AuNPs) were used as carriers of aptamers tagged with a positively charged tetramethylrhodamine (TAMRA), which catalyzed silver reduction and deposition. The TAMRA attracted and retained the silver lactate around the AuNPs due to the attraction between positive and negative charges, increasing the chance of AuNP-catalyzed silver reduction. The charge effect-assisted silver enhancement was confirmed by tagging aptamers of different base pair lengths with TAMRA. The as-prepared OTA aptasensor exhibited a working range of 1 x 10(2)-1 x 10(6) pg mL(-1) and a detection limit of 28.18 pg mL(-1). It was successfully applied to determine OTA in actual samples with satisfactory results.
Article
Chemistry, Analytical
Jintao Dong, Feng Chen, Li Xu, Pengcheng Yan, Junchao Qian, Yun Chen, Mengying Yang, Henan Li
Summary: A highly sensitive and selective photoelectrochemical aptasensor was developed for detecting trace chloramphenicol. The aptasensor, based on Ag nanoparticles sensitized bismuth oxyiodide composites, showed enhanced CAP detection performance with wide linear range, low detection limit, and superior selectivity. Moreover, the aptasensor exhibited favorable stability and reproducibility.
MICROCHEMICAL JOURNAL
(2022)
Article
Engineering, Environmental
Yu Zhang, Guanyu Wu, Yun Chen, Pengcheng Yan, Li Xu, Junchao Qian, Feng Chen, Yuting Yan, Henan Li
Summary: In this study, a photoelectrochemical (PEC) aptasensor was developed using Co(II) doped g-C3N4 nanotubes for the specific detection of Atrazine (ATZ). The aptamer improved the selectivity of the sensor through specific recognition with ATZ. The PEC aptasensor showed excellent selectivity and stability in real water samples. This work provides a simplified and cost-effective method for detecting ATZ and insights into the detection of other pollutants.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Analytical
Qingfa Gong, Shuyun Meng, Dong Liu, Tianyan You
Summary: In this study, a sensitive PEC apta-sensor was constructed based on a direct Z-scheme heterojunction for the detection of ochratoxin A (OTA). By manipulating the conductivity and hydrophilicity of the materials, the separation of charge carriers and amplification of PEC signal were achieved, enabling the detection of OTA. The developed aptasensor exhibited a wide linear detection range and low detection limit, as well as good selectivity and stability.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jintao Dong, Li Xu, Shuangbo Dang, Shanxin Sun, Yucheng Zhou, Pengcheng Yan, Yuting Yan, Henan Li
Summary: A sensitive and selective photoelectrochemical aptasensor was developed using Au/Bi24O31Br10 composites for highly sensitive detection of enrofloxacin. The aptasensor exhibited a broad linear detection range, low detection limit, high selectivity, and stability.
Article
Chemistry, Analytical
Zekun Zheng, Long Ma, Baoyu Li, Xiaomei Zhang
Summary: A dual-mode biosensor based on FePor-TPA was successfully constructed for the detection of Staphylococcus aureus. FePor-TPA exhibited excellent catalytic activity and conductivity, and its powder form could be used to load signal probes for catalytic amplification.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Xiaoqing Zhang, Tianning Li, Xuening Gao, Jingwen Lin, Baizhao Zeng, Chuqing Gong, Faqiong Zhao
Summary: In this study, a molecularly imprinted photoelectrochemical (PEC) sensor was developed for the detection of chlortetracycline (CTC) using a sensitized ZnO-MWCNTs-NH2 electrode. The sensor exhibited good sensitivity and selectivity towards CTC, and could be used for the detection of CTC in actual samples.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Lin Cui, Jingzhu Shen, Chen-Chen Li, Pei-Pei Cui, Xiliang Luo, Xiaolei Wang, Chun-Yang Zhang
Summary: DNA methyltransferases can be important biomarkers for cancers and genetic diseases, and a dye-sensitized and gold plasmon-enhanced cathodic photoelectrochemical biosensor has been developed based on p-type covalent organic polymers for the signal-on measurement of M.SssI methyltransferase. This biosensor shows high sensitivity and good selectivity, capable of screening inhibitors and detecting M.SssI MTase in serum.
ANALYTICAL CHEMISTRY
(2021)
Article
Biophysics
Hao Wang, Bianbian Zhao, Yufei Ye, Xiaoyu Qi, Yuting Zhang, Xiaole Xia, Xiaoli Wang, Nandi Zhou
Summary: In this study, a fluorescence and surface-enhanced Raman scattering dual-mode aptasensor was developed for sensitive and rapid detection of Ochratoxin A (OTA). The aptasensor demonstrated low detection limits in both FL and SERS modes, as well as high specificity and good interferent resistance. It showed great potential for OTA detection in coffee and wine samples.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Physical
Yuqin Wei, Yan Chen, Rui Yuan, Zhaoli Xue, Long Zhao
Summary: Modification of molecular structure can enhance photocatalytic activity by reducing interfacial electron-hole recombination. Two zinc porphyrins are synthesized and doped on TiO2 for photodegrading an organic pollutant AB1. The composite with TPA-BiPh-ZnP exhibits faster degradation kinetics than the composite with Cb-Ph-ZnP.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemical Research Methods
Maosheng Sang, Xiaoya Meng, Yuhao Zhang, Zhongyu Li, Quanlong Zhou, Xiangzhu Jing, Xia Sun, Wenping Zhao
Summary: This study developed a highly selective and sensitive on-off-on electrochemiluminescence (ECL) aptasensor for the detection of ochratoxin A (OTA) using a self-enhanced luminophore. The aptasensor demonstrated good sensitivity, stability, and reproducibility, with a linear detection range of 0.1-320 ng/mL and a detection limit of 0.03 ng/mL. It provided a common analytical tool for the detection of mycotoxins and other small molecules.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Zahra Khoshbin, Elham Sameiyan, Hamed Zahraee, Mohammad Ramezani, Mona Alibolandi, Khalil Abnous, Seyed Mohammad Taghdisi
Summary: In this study, a simple aptasensing approach was used to detect ochratoxin A (OTA), a dangerous mycotoxin with severe health effects. The aptasensor utilized the alteration of liquid crystal (LC) molecules at the surfactant-arranged interface to sensitively detect OTA. By perturbing the alignment of LCs, the presence of OTA induced a noticeable change in the polarized view of the aptasensor substrate. The aptasensor demonstrated high sensitivity and could detect OTA in various real samples.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Applied
Yan Guan, Peng-Bin Si, Tong Yang, Yuan Wu, Yun-Hui Yang, Rong Hu
Summary: A DNA walker-based dual-signal electrochemical ratiometric platform was developed for OTA detection, using Co-MOFs and toluidine blue as signal tag and reference probe. The method displayed superior sensitivity and reproducibility, with comparable results to commercial enzyme-linked immunoassay kits in determining OTA content in red wine samples.
Article
Electrochemistry
Fan Yang, Yue Zheng, Xiaochun Tian, Yan Liu, Jinhua Li, Zongze Shao, Feng Zhao
Summary: The study demonstrated that Bacillus horikoshii biET1 can oxidize manganese ions into manganese oxides under oxic conditions and rapidly reduce biogenic Mn(III/IV) oxides under anoxic conditions. The redox cycling of microbial manganese metabolism is reversible and sustainable.
ELECTROCHIMICA ACTA
(2021)
Article
Energy & Fuels
Qin Pan, Xiaochun Tian, Junpeng Li, Xuee Wu, Feng Zhao
Summary: This review discusses the electron transfer mechanisms in converting carbon dioxide to value-added products using microbial electro- or photosynthesis, categorizing them into direct and indirect pathways. It reveals the crucial roles of inorganic catalysts and microbes in enhancing the efficiency and selectivity of CO2 conversion.
Article
Engineering, Environmental
Rui Ding, Yan Wu, Fan Yang, Xiaofeng Xiao, Yidi Li, Xiaochun Tian, Feng Zhao
Summary: The study found that using a synergistic method combining photocatalysis and a microbial community is feasible for degrading low concentrations of PFOA, with microorganisms increasing the removal efficiency and contributing to additional removal of total organic carbon and defluorination percentage. The enrichment of specific microbial genera in the functional microbial community was shaped by both photocatalysis and substances, providing insight into improving the removal efficiency of the synergistic system.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biophysics
Yong Xiao, Geng Chen, Zheng Chen, Rui Bai, Biyi Zhao, Xiaochun Tian, Yicheng Wu, Xiao Zhou, Feng Zhao
Summary: The study shows that interspecific competition significantly influences the performance of bioelectrochemical systems, enhancing the metabolic activity and exoelectrogenic capacity of S. oneidensis MR-1. This competition helps S. oneidensis MR-1 to form biofilms on electrodes and gain a competitive advantage over C. freundii An1.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Environmental Sciences
Junpeng Li, Xiaochun Tian, Rui Bai, Xiaofeng Xiao, Fan Yang, Feng Zhao
Summary: The study found that the HP-7 strain and hydroxyapatite can reduce the bioavailability of Pb(II) in PbCO3, providing new insights for the remediation of lead-polluted environments.
Article
Biochemistry & Molecular Biology
Xinyi Liao, Qin Pan, Xiaochun Tian, Xuee Wu, Feng Zhao
Summary: The study utilized Rhodopseudomonas palustris CGA009 to investigate CO2 bioreduction behavior at different potentials. The results indicated that the cathodic potential positively influenced the NAD(P)-binding domain protein of R. palustris CGA009.
PROCESS BIOCHEMISTRY
(2022)
Article
Chemistry, Analytical
Xiaochun Tian, Ranran Wu, Xiang Li, Xuee Wu, Yanxia Jiang, Feng Zhao
Summary: The redox properties of electroactive bacteria are crucial for biogeochemical cycling, environmental remediation, and bioenergy generation. However, the detailed mechanisms of the redox properties of living cells remain unclear. In this study, we conducted a series of electrochemical tests mediated by FcMeOH to investigate the bacterial electrode process. The results revealed that the electrochemical oxidation followed by biocatalytic reduction occurs in the electroactive bacteria. Furthermore, an irreversible process for the redox behaviors of Shewanella oneidensis MR-1 was observed, suggesting that electrons may transfer among redox flavocytochromes at the cell membrane, forming a conductive network for cathodic electron transfer.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yidi Li, Xiaochun Tian, Lixiang Chen, Junpeng Li, Feng Zhao
Summary: This study found that electron transfer at the biotic-abiotic interface can be enhanced under visible light. Non-photosynthetic microorganisms can capture and utilize visible light by transferring electrons to the valence band of carbon nitride, and this electron transfer is facilitated by the cyclic conversion of riboflavin.
BIOELECTROCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xiaochun Tian, Rui Bai, Feng Zhao
Summary: Microbial hybrid photosynthesis integrates the advantages of natural and artificial photosynthesis and has attracted great interest. Scanning photoelectrochemical microscopy (SPECM) shows great potential in investigating the interfacial reactions of microbial hybrid photosynthesis, and it can also be applied in fields such as biomineralization, photocatalytic-biodegradation, and microbial photoelectrochemical systems.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Oncology
Shuqi Wu, Xiaochun Tian, Qian Mao, Chang Peng
Summary: This study aimed to explore whether azithromycin (AZM) attenuates post-inflammatory wheezing by inhibiting hypermethylation of histone H3K27me3 mediated by EZH2. The results showed that the expression levels of IL-6, IL-2, NF-kappa B P65, EZH2, and H3K27me3 in the BALF of wheezing cases were significantly increased, while IL-10 was decreased. AZM attenuated the overexpression of NF-kappa B P65, EZH2, and H3K27me3 in wheezing cases and shortened the time of wheezing.
CLINICAL EPIGENETICS
(2023)
Review
Chemistry, Multidisciplinary
Chongyuan Ren, Rui Bai, Wei Chen, Junpeng Li, Xudong Zhou, Xiaochun Tian, Feng Zhao
Summary: This review summarizes the recent development of the nanomaterial-microbe system for the removal of emerging contaminants, which is divided into exogenous nanomaterial-microbe and endogenous nanomaterial-microbe. The interaction mechanism of materials and microorganisms is addressed from the particular perspective of extracellular electron transfer and redox reactions, and the advantages and challenges of the pollutants treatment are analyzed. Furthermore, future applications in the degradation of emerging contaminants in environmental fields have been prospected.
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
(2023)
Article
Engineering, Environmental
Junpeng Li, Rui Bai, Wei Chen, Chongyuan Ren, Fan Yang, Xiaochun Tian, Xiaofeng Xiao, Feng Zhao
Summary: Mineralization of lead ions (Pb2+) to pyromorphite using phosphorus-containing materials is an effective way to remediate lead (Pb) contamination. In this study, bone char and Pseudomonas rhodesiae HP-7 were encapsulated into bio-beads to investigate their immobilization performance and mechanism of Pb in solution and soil. The results showed that bone char could be turned into an efficient Pb immobilization material in the presence of phosphate-solubilizing bacteria, and the bio-beads exhibited good stability in long-term soil remediation.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Xiang Li, Xiaochun Tian, Xinyu Yan, Nan Huo, Xuee Wu, Feng Zhao
Summary: This study clarifies the mechanism of the interface process in microbial photoelectrochemical systems. High-performance liquid chromatography-mass spectrometry analysis showed that riboflavin secreted by Rhodopseudomonas palustris was photolyzed to lumichrome. Additionally, the anodic current increased by 75% after adding lumichrome, demonstrating that lumichrome, as an electron shuttle, facilitates microbial electron transfer.
BIOELECTROCHEMISTRY
(2023)
Review
Chemistry, Analytical
Tian Xiao-Chun, Li Yi-Di, Pan Qin, Zhao Feng
Summary: Microbes play a key role in element biogeochemical cycle, redox reactions, and electron transfer, while electrochemical technologies can reveal the electron transfer mechanism at the biotic-abiotic interface. SECM technology allows high sensitivity monitoring of microbial respiratory activity, electricity generation ability, and micro-environmental factors of biofilms.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2021)
Article
Environmental Sciences
Yidi Li, Lixiang Chen, Xiaochun Tian, Lifeng Lin, Rui Ding, Weifu Yan, Feng Zhao
Summary: The combination of photocatalytic-biodegradation using polyurethane sponges modified with visible light-responsive g-C3N4 and mixed culture microbes resulted in 94% removal of ciprofloxacin. This method had a higher total organic carbon (TOC) removal rate compared to photocatalytic degradation alone. The microbial community primarily belonged to Proteobacteria, playing a major role in the efficient degradation process.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)