Article
Chemistry, Analytical
Hongjing Yang, Jiao Liu, Lina Wang, Lifeng Ma, Fei Nie, Guoping Yang
Summary: The novel complex [Co(L)(H2O)2] (1) showed unique 1D chain structure and stability, exhibited excellent catalytic activity and substrate affinity, with recyclability and low storage requirements. A chemiluminescence method for detecting glutathione was proposed based on its characteristics, achieving satisfactory results.
Article
Biochemical Research Methods
Hongjing Yang, Jiao Liu, Xuan Feng, Fei Nie, Guoping Yang
Summary: The newly synthesized Cu-based metal-organic framework (Cu-MOF) exhibited high catalytic activity as a peroxidase-mimicking enzyme and demonstrated strong affinity towards hydrogen peroxide. The catalytic mechanism of Cu-MOF, primarily driven by cupric ions, was found to efficiently generate free radicals and facilitate electron transfer during reactions. Its high affinity for hydrogen peroxide made Cu-MOF an ideal catalyst for chemiluminescence reactions, thus enabling the development of a sensitive detection method for various substrates.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Pei-Hong Tong, Jing-Jing Wang, Xi-Le Hu, Tony D. James, Xiao-Peng He
Summary: Inspired by natural enzymes, a bifunctional metal-organic framework (MOF), AuNPs@PCN-224(Fe), was developed for biosensing applications. The hybridized nanozyme, consisting of ultrasmall gold nanoparticles (AuNPs) and iron porphyrin-based MOF (PCN-224(Fe)), exhibited the catalytic activities of glucose oxidase (GOx) and horseradish peroxidase (HRP). The bifunctional nanozyme enabled a cascade reaction to generate hydrogen peroxide and activate a colorimetric or chemiluminescent substrate. Selectivity over other saccharides and high catalytic activity retention were observed.
Article
Spectroscopy
Wensong Yao, Xiaomin Zhang, Zhen Lin
Summary: The study demonstrates that sodium molybdate significantly enhances the chemiluminescent reaction between hydrogen peroxide and luminol, providing a convenient and sensitive method for hydrogen peroxide determination, as well as potential application for glucose detection when combined with glucose oxidase. This finding suggests promising applications of sodium molybdate in analytical chemistry.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Hossein Abdolmohammad-Zadeh, Farzaneh Ahmadian
Summary: This study developed a nano-probe based on the peroxidase-like property of MoS2@MIP-202(Zr) nano-composite for the indirect detection of residue levels of diazinon in water samples. The high stability of the nanocomposite makes it a good alternative for natural peroxidase enzymes such as horseradish peroxidase with low stability.
ANALYTICA CHIMICA ACTA
(2023)
Article
Nanoscience & Nanotechnology
Congcong Lv, Xiaoyan Guo, Yue Hou, Wei Liu, Yanli Guo, Zixuan Zhang, Yan Jin, Baoxin Li
Summary: The paper successfully transformed the flash-type system of luminol into a long-lasting chemiluminescence system by loading Cu(II)-based organic complex on the paper substrate, achieving a long-lasting emission of over 30 minutes. By controlling the amount of water in the synthesis process, the morphology of the complex can be adjusted, thus controlling the luminescent effect.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Masih Darbandi, Maryam Sadat Alahmadi, Mohammad Amjadi, Tooba Hallaj
Summary: Mesoporous cobalt oxides have important applications due to their exceptional properties. In this study, mesoporous Co3O4 NPs with different porosity were successfully synthesized through a sonochemical process. The synthesized NPs were characterized using XRD, BET, and TEM. The catalytic effect of the Co3O4 NPs in the luminol-H2O2 chemiluminescence system was studied, and the system was used to detect and measure H2O2 and glucose under optimal conditions. The proposed method showed a good linear relationship and excellent LOD for both H2O2 and glucose.
Article
Nanoscience & Nanotechnology
Shengdong Mu, Yuting Deng, Zhenyu Xing, Xiao Rong, Chao He, Sujiao Cao, Tian Ma, Chong Cheng, Yinghan Wang
Summary: In this study, a new nanoreactor was created by mimicking peroxidase to meet the needs of bio-diagnosis. The nanoreactor showed exceptional diagnostic activity and high substrate selectivity, enabling ultrasensitive and visual detection of various biomarkers.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Rui Yang, Wenxuan Dong, Yueran Ren, Yangyang Xue, Hua Cui
Summary: Novel luminol functionalized nanoparticles were synthesized and used for sensitive detection of glucose and uric acid. The method showed potential for application in biological detection fields.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Huairong Zhang, Yong Liu, Mei Yao, Wenxiu Han, Shusheng Zhang
Summary: Cathodic electrochemiluminesence (ECL) microscopy based on luminol analog L012 utilizes multiwalled carbon nanotubes (MWCNTs) as coreactant accelerators to convert oxygen and H2O2 into reactive oxygen species. The produced ROS oxidizes L012 to emit bright cathodic ECL illumination, enabling the imaging of nanotubes and nucleolin on tumor cells. By modifying MWCNTs with AS1411 aptamers, label-free ECL imaging of nucleolin on plasma membranes was achieved, providing a universal approach in single nanomaterial and single-cell imaging.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Lucia Simona Ferraraccio, Donatella Di Lisa, Laura Pastorino, Paolo Bertoncello
Summary: A simple procedure for incorporating enzymes into alginate hydrogels was reported, and electrochemiluminescence was used for detecting the enzymatic reactions. The immobilized enzymes showed maintained activity and good stability within the alginate hydrogels for up to 28 days. The sensitivity and selectivity of the encapsulated enzymes were demonstrated through testing real samples.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Daler R. Dadadzhanov, Igor A. Gladskikh, Mikhail A. Baranov, Tigran A. Vartanyan, Alina Karabchevsky
Summary: Chemiluminophores generate wide-band light emission through a chemical reaction without external light source. Plasmonic nanoparticles can enhance chemiluminescence quantum yield by accelerating radiative decay rate, while the catalytic action of metallic surface can increase the chemical reaction rate. Using an inert spacer layer on a silver metasurface may favor an electrodynamic mechanism for moderate chemiluminescence enhancement.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Shaida Mahmoudi, Mohamad Javad Chaichi, Mojtaba Shamsipur, Ome Leila Nazari, Abdolraouf Samadi-Maybodi
Summary: A Fe3O4@Zn/Mg MOF composite with high peroxidase-like activity was synthesized and utilized for measuring atropine in Datura plants. This method is characterized by its fast, reversible, and selective features.
Article
Nanoscience & Nanotechnology
Min Chen, Xiaocheng Zhou, Can Xiong, Tongwei Yuan, Wenyu Wang, Yafei Zhao, Zhenggang Xue, Wenxin Guo, Qiuping Wang, Huijuan Wang, Yafei Li, Huang Zhou, Yuen Wu
Summary: Nanomaterials with natural enzyme-mimicking characteristics have attracted great attention due to their low cost, easy large-scale production, and environmental resistance. This study investigates the effect of different crystal facets on the peroxidase-mimetic activity of fluorite cubic CeO2 nanocrystals. The results show that CeO2 nanorods dominated by the {110} facet exhibit the highest peroxidase-mimetic activity due to the abundance of surface defects, which enhance their artificial enzymatic functionality for cascade catalysis. Additionally, the introduction of atomic dispersed Au on the CeO2 nanorods enhances the peroxidase activity and enables glucose oxidase-mimicking activity for enzyme-free cascade reactions.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Miaomiao Tian, Liping Zhao, Ya Wang, Gang Liu, Peng Zhang
Summary: Bimetallic Pt/Ag nanoparticles were synthesized and demonstrated to possess excellent catalytic performance and stability for use in chemiluminescence sensors.
ANALYTICAL LETTERS
(2023)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)