Article
Medicine, General & Internal
Iulia Ratiu, Raluca Lupusoru, Alina Popescu, Ioan Sporea, Adrian Goldis, Mirela Danila, Bogdan Miutescu, Tudor Moga, Andreea Barbulescu, Roxana Sirli
Summary: This observational retrospective study aimed to investigate the differences and associated factors between variceal and nonvariceal upper gastrointestinal bleeding (UGIB). The results showed that there was a higher rebleeding rate in patients with variceal bleeding.
Editorial Material
Medicine, General & Internal
Jeffrey L. Tokar, Jennifer T. Higa
Summary: This article reviews the presentation, treatment, and prevention of acute gastrointestinal bleeding (GIB) and emphasizes the collaborative care between internists and other specialists, as well as the pivotal role of primary care providers in managing acute GIB.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Hematology
Amir Samii, Mahshaad Norouzi, Abbas Ahmadi, Akbar Dorgalaleh
Summary: GIB is a serious condition that is difficult to manage due to heterogeneity in CBDs. Evaluating the hematological status and providing urgent interventions for high-risk patients are crucial. The best management strategy for CFD-related bleeding remains controversial.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Article
Gastroenterology & Hepatology
Loren Laine, Alan N. Barkun, John R. Saltzman, Myriam Martel, Grigorios I. Leontiadis
Summary: Systematic reviews were conducted to develop recommendations for the management of patients with overt upper gastrointestinal bleeding, suggesting risk assessment and red blood cell transfusion based on hemoglobin levels. Endoscopic therapy is recommended for ulcers with active bleeding or nonbleeding visible vessels, with repeat endoscopy and transcatheter embolization options available if therapy fails.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Joseph J. Y. Sung, Loren Laine, Ernst J. Kuipers, Alan N. Barkun
Summary: Personalized management strategies should be based on patient characteristics, nature of bleeding lesions, and clinical setting, including available resources.
Article
Agriculture, Dairy & Animal Science
Yajie Chen, Manabu Niimi, Lan Zhang, Xiangming Tang, Jian Lu, Jianglin Fan
Summary: In this study, a new telemetry sensor system was developed to continuously monitor the body temperature of rabbits. The sensor was implanted subcutaneously and the temperature changes were recorded by a personal computer. The temperature data obtained from the telemetry system was consistent with the rectal temperature measured by a digital device. The analysis of body temperature changes confirmed the reliability and usefulness of this system, both in normal conditions and when fever was induced by endotoxin.
Article
Hematology
Floris T. M. Bosch, Frits Mulder, Menno Huisman, Jeffrey Zwicker, Marcello Di Nisio, Marc Carrier, Annelise Segers, Peter Verhamme, Saskia Middeldorp, Jeffrey Weitz, Michael A. Grosso, Anil Duggal, Harry R. Buller, Tzu-Fei Wang, David Garcia, Pieter Willem Kamphuisen, Gary E. Raskob, Nick van Es
Summary: In gastrointestinal cancer patients receiving edoxaban, advanced cancer and low hemoglobin levels were significantly associated with an increased risk of gastrointestinal bleeding. However, further research is needed to identify other risk factors.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Pediatrics
Jayendra Seetharaman, Rajanikant R. Yadav, Anshu Srivastava, Moinak Sen Sarma, Sheo Kumar, Ujjal Poddar, Surender Kumar Yachha
Summary: This study analyzed the etiology, clinical presentation, and outcome of radiological embolization in children with visceral artery pseudoaneurysm (PSA) of celiac (CA) or superior mesenteric artery (SMA) branches. It was found that liver abscess, trauma, and pancreatitis are common causes of PSA in children, with a majority presenting with gastrointestinal bleeding identified on computed tomography angiography (CTA). Radiological embolization was shown to be safe with a success rate of 100%.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Medicine, General & Internal
Lucia Maria Sur, Ionel Armat, Genel Sur, Ioana Badiu Tisa, Madalina Adriana Bordea, Iulia Lupan, Gabriel Samasca, Calin Lazar
Summary: Upper gastrointestinal bleeding is a potentially life-threatening condition in children, with causes varying by age. The impact on the child is often related to the amount of blood lost, ranging from mild to severe cases requiring intensive care unit admission. This article aims to summarize current research on the diagnosis and treatment of upper gastrointestinal bleeding in children.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Electrical & Electronic
Nicola Trivellin, Matteo Buffolo, Carlo De Santi, Matteo Meneghini, Michele Forzan, Fabrizio Dughiero, Enrico Zanoni, Gaudenzio Meneghesso
Summary: A contactless temperature measurement method based on PL of AlInGaP LED structure has been proposed and evaluated, showing high precision. The method involves excitation by laser and measurement by spectrometer. Three key factors affecting measurement results are peak value, spectral width, and spectrometer resolution.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bari Dane, Avneesh Gupta, Michael L. Wells, Mark A. Anderson, Jeff L. Fidler, Haresh V. Naringrekar, Brian C. Allen, Olga R. Brook, David H. Bruining, Michael S. Gee, David J. Grand, David Kastenberg, Ashish Khandelwal, Neil Sengupta, Jorge A. Soto, Flavius F. Guglielmo
Summary: Gastrointestinal (GI) bleeding is a life-threatening condition with a high incidence of hospitalizations. CT angiography is recommended as a first-line diagnostic tool for severe hematochezia patients due to its ability to locate the source of bleeding. Dual-energy CT (DECT) offers advantages such as significant radiation dose reduction and improved diagnostic accuracy through virtual noncontrast (VNC) images and postprocessing techniques. Radiologists should consider the potential pitfalls and limitations of DECT in diagnosing GI bleeding.
Article
Multidisciplinary Sciences
Jeemyoung Kim, Eun Jeong Gong, Myeongsook Seo, Jong Kyu Park, Sang Jin Lee, Koon Hee Han, Young Don Kim, Woo Jin Jeong, Gab Jin Cheon, Hyun Il Seo
Summary: This study aimed to compare the clinical outcomes of urgent endoscopy and elective endoscopy in patients with acute upper gastrointestinal bleeding (UGIB). The results showed that there was no difference in mortality rate within 30 days between urgent endoscopy and elective endoscopy.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Analytical
Cormac D. Fay, Andrew Nattestad
Summary: This study investigates the impact of embedded software-driven measurements on using an LED as a photodetector. By using water turbidity as the sensory target, the chosen software method is found to significantly affect the detection performance, sampling frequency, and photo capacitance error. Optimized code is proposed to improve these issues.
Review
Medicine, General & Internal
Josh Orpen-Palmer, Adrian J. Stanley
Summary: Upper gastrointestinal bleeding is a common medical emergency that requires thorough assessment and resuscitation to stabilize the patient. Risk scores are important in distinguishing between low- and high-risk patients, allowing for appropriate outpatient or inpatient management. Advances in machine learning and artificial intelligence show promise in predicting poor outcomes and may be used for dynamic risk assessment in the future.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Angela Saviano, Mattia Brigida, Carmine Petruzziello, Marcello Candelli, Maurizio Gabrielli, Veronica Ojetti
Summary: NOACs are a safer alternative to warfarin for the prevention and treatment of thromboembolic cardiovascular conditions. Studies have shown that apixaban has a lower rate of gastrointestinal bleeding compared to dabigatran and rivaroxaban, and gastrointestinal bleeding in patients treated with NOACs is generally less severe than with warfarin. The use of NOACs is increasing and widespread in patients who require anticoagulation, with an overall lower risk of major bleeding events. However, caution is still needed in patients at high risk of gastrointestinal bleeding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)