Review
Oncology
Dasha T. Cogswell, Laurent Gapin, Heather M. Tobin, Martin D. McCarter, Richard P. Tobin
Summary: This review highlights the significance of MAIT cells in various diseases, including bacterial, parasitic and fungal infections, viral infections, autoimmune diseases, and different cancers. The impact of MAIT cells on the tumor microenvironment varies depending on factors such as cancer type, subset of MAIT cell, patient demographics, microbiome composition, and therapy type. Further research is needed to fully understand these interactions.
Article
Cardiac & Cardiovascular Systems
Carmen Hannemann, Johannes H. Schecker, Alica Brettschneider, Jana Grune, Nicole Roesener, Andrea Weller, Verena Stangl, Edward A. Fisher, Karl Stangl, Antje Ludwig, Bernd Hewing
Summary: The study demonstrated that deficiency of iRhom2 can reduce the development of atherosclerosis, particularly in early stages. Additionally, iRhom2 deficiency was found to lower serum levels of TNF-alpha, as well as circulating and hepatic levels of cholesterol and triglycerides.
CARDIOVASCULAR RESEARCH
(2022)
Review
Immunology
Hui Ma, Caroline Murphy, Christine E. E. Loscher, Richard O'Kennedy
Summary: Autoantibodies, which can cause severe autoimmune diseases, can also be used as important tools in disease diagnosis, prognosis, and treatment. They can be detected early in disease development, have better stability than their related antigens, and can be used to enhance diagnostics and predict prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Business, Finance
Alessandro Bitetto, Paola Cerchiello
Summary: Initial Coin Offerings (ICOs) have gained interest as an alternative fundraising method in the FinTech world. This paper investigates the connection between ICOs and Environmental, Social and Governance (ESG) indicators by studying 871 ICOs. Preliminary results confirm that ICOs focused on ESG are more likely to successfully raise funds.
FINANCE RESEARCH LETTERS
(2023)
Review
Medicine, General & Internal
Elena Pasini, Roberto Michelucci
Summary: There is a close relationship between the heart and seizures, and studying this relationship is important for preventing cardiac risks and predicting epileptic seizures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Sung Won Lee, Jonggi Choi, Seung Up Kim, Young-Suk Lim
Summary: ETV and TDF have similar short to intermediate-term efficacy, but there are still controversies surrounding their antiviral efficacy in preventing the development of HCC.
CLINICAL AND MOLECULAR HEPATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Aleksandra Mladenovic Djordjevic, Natasa Loncarevic-Vasiljkovic, Efstathios S. Gonos
Summary: It is well established that lifestyle and dietary habits have a significant impact on life span, aging rate, and age-related diseases. Dietary restriction and healthy dietary patterns have been linked to increased survival and longevity, with the ability to modify oxidative stress levels. However, the debate regarding the role of dietary restriction as a golden standard for prolonging life span and ameliorating aging effects continues.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Medicine, General & Internal
Eugenia Enriquez-Merayo, Maria J. Cuadrado
Summary: Glucocorticoids are effective in reducing immune activation and inflammation, but their side effects limit their use in long-term treatment. Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs and systems, and current treatments include corticosteroids and immunosuppressive medications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Microbiology
Xiaofeng Lu, Jingjing Liu, Bing Zhou, Shuwei Wang, Zhifang Liu, Fuyang Mei, Junxiang Luo, Yong Cui
Summary: The gut microbiome has recently been found to be associated with heart failure (HF), a global health issue characterized by cardiac dysfunction. Although the underlying mechanism is still unclear, studies have suggested that microbial metabolites influenced by dietary factors may affect the development of HF. This review focuses on the advances and potential therapeutic targets in HF related to trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs), and bile acids (BAs), as well as the potential application of microbial metabolites in HF therapy.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Plant Sciences
Nora Gigli-Bisceglia, Christa Testerink
Summary: Plants react to environmental stress through specific cellular mechanisms, with overlapping strategies in salt and pathogen perception. Understanding these mechanisms helps explain the complex plant responses to pathogens and salinity.
CURRENT OPINION IN PLANT BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Anja Adelina Giese, Aaron Babendreyer, Peter Krappen, Annika Gross, Pavel Strnad, Stefan Dusterhoft, Andreas Ludwig
Summary: ADAM17 is involved in inflammatory and proliferative responses by shedding cell-surface molecules, and iRhom2 expression is upregulated in acute colitis and inflammatory bowel disease. Upregulation of iRhom2 leads to increased expression of ADAM17, resulting in enhanced cleavage of specific factors.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Joseph Skurski, Garima Dixit, Carl P. Blobel, Priya D. Issuree, Thorsten Maretzky
Summary: A well-controlled innate immune response is characterized by a rapid yet self-limiting inflammatory response, with complex regulatory mechanisms. This study reveals the key role of ADAM17 in regulating the release of TNF, and the signaling of TNFRs in immune cells also plays a regulatory role in TNF expression.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Endocrinology & Metabolism
Antonio Citro, Francesco Campo, Erica Dugnani, Lorenzo Piemonti
Summary: Type 1 diabetes remains challenging to treat, with available methods unable to effectively delay the onset and progression of the disease. Recent research has revealed that diabetes is not solely mediated by T cells in autoimmune processes, as macrophages and neutrophils also play a role in beta cell destruction. Understanding the regulation of cytokines is essential in improving glucose metabolism and preventing autoimmune damage.Combining immunomodulatory strategies targeting both innate and adaptive immunity may be more effective in preventing or delaying islet damage and T1D onset.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Medicine, Research & Experimental
Karen Leal Fischer, Manon Jaffredo, Jochen Lang, Matthieu Raoux
Summary: Diabetes is a major metabolic disease caused by reduced secretion and action of insulin, and alpha cells within the pancreatic islets may enhance beta cell activity under certain physiological conditions, playing a significant role in the regulation of nutrient homeostasis.
M S-MEDECINE SCIENCES
(2021)
Review
Cell Biology
Dana L. Woodstock, Morgan A. Sammons, Martin Fischer
Summary: p53 and p63, as transcription factors, regulate both shared and unique target genes to exert their tumor suppressive or oncogenic effects. The previous notion of strict competition between the two siblings needs to be reevaluated, as they can also collaborate towards a common goal.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Tiago Clemente, Narcisio J. Vieira, Juan P. Cerliani, Colin Adrain, Alexander Luthi, Mariana R. Dominguez, Monica Yon, Fernanda C. Barrence, Thalita B. Riul, Richard D. Cummings, Telma M. Zorn, Sebastian Amigorena, Marcelo Dias-Baruffi, Mauricio M. Rodrigues, Seamus J. Martin, Gabriel A. Rabinovich, Gustavo P. Amarante-Mendes
CELL DEATH & DISEASE
(2017)
Article
Biology
Ioanna Oikonomidi, Emma Burbridge, Miguel Cavadas, Graeme Sullivan, Blanka Collis, Heike Naegele, Danielle Clancy, Jana Brezinova, Tianyi Hu, Andrea Bileck, Christopher Gerner, Alfonso Bolado, Alex von Kriegsheim, Seamus J. Martin, Florian Steinberg, Kvido Strisovsky, Colin Adrain
Article
Endocrinology & Metabolism
Marina Badenes, Abdulbasit Amin, Ismael Gonzalez-Garcia, Ines Felix, Emma Burbridge, Miguel Cavadas, Francisco Jose Ortega, Erika de Carvalho, Pedro Faisca, Stefania Carobbio, Elsa Seixas, Dora Pedroso, Ana Neves-Costa, Luis F. Moita, Jose Manuel Fernandez-Real, Antonio Vidal-Puig, Ana Domingos, Miguel Lopez, Colin Adrain
MOLECULAR METABOLISM
(2020)
Editorial Material
Biochemistry & Molecular Biology
Abdulbasit Amin, Ana Neves-Costa, Dora Pedroso, Henrique Colaco, Ines Coelho, Ines Mahu, Marina Badenes, Nadia Duarte
Review
Biochemistry & Molecular Biology
Colin Adrain, Miguel Cavadas
Editorial Material
Biochemistry & Molecular Biology
Colin Adrain
Summary: The word 'metabolism' comes from the Greek term metavoli (metabole), meaning 'change'. It is now understood that cell behavior is closely linked to metabolism, and disruptions in metabolite abundance or flux can deeply affect cellular (and whole-body) function, leading to disease. Metabolism plays a crucial role in both health and disease, with most diseases being considered metabolic diseases; modulating metabolism may be key in changing disease outcomes.
Article
Biochemistry & Molecular Biology
Catarina J. Gaspar, Ligia C. Vieira, Cristiana C. Santos, John C. Christianson, David Jakubec, Kvido Strisovsky, Colin Adrain, Pedro M. Domingos
Summary: The ER membrane protein complex (EMC) is essential for the biogenesis of a subset of tail anchored (TA) and polytopic membrane proteins in Drosophila, including Rhodopsin-1 (Rh1) and the TRP channel. This study identified that EMC is required for the biogenesis of the proteins fan and Xport-A, where Xport-A plays a crucial role in the biogenesis of both Rh1 and TRP. Additionally, it was found that Xport-A is involved in a glycosylation-dependent triage mechanism during Rh1 biogenesis in the endoplasmic reticulum.
Editorial Material
Biochemistry & Molecular Biology
Emma Burbridge, Colin Adrain
Summary: This article discusses the importance and mechanisms of maintaining organelle homeostasis in cells, providing a comprehensive perspective on the functions and interactions of various organelles. It also introduces some lesser-known organelles.
Article
Biology
Marina Badenes, Emma Burbridge, Ioanna Oikonomidi, Abdulbasit Amin, Erika de Carvalho, Lindsay Kosack, Camila Mariano, Pedro Domingos, Pedro Faisca, Colin Adrain
Summary: ADAM17 is a metalloprotease that sheds key molecules, including TNF and epidermal growth factor receptor ligands. It exists within a sheddase complex, including iRhom1 or iRhom2. The protein iTAP/Frmd8 is an iRhom-binding protein that regulates ADAM17 biology. The loss of iTAP/Frmd8 affects inflammatory and intestinal epithelial barrier repair functions, and also regulates cancer cell growth. Targeting iTAP/Frmd8 may be beneficial for specific ADAM17-related diseases, avoiding the collateral impact of widespread ADAM17 inhibition.
LIFE SCIENCE ALLIANCE
(2023)
Correction
Oncology
Marina Badenes, Alexandre Trindade, Hugo Pissarra, Luis Lopes-da-Costa, Antonio Duarte
Article
Oncology
Marina Badenes, Alexandre Trindade, Hugo Pissarra, Luis Lopes-da-Costa, Antonio Duarte
