Article
Spectroscopy
Heera Jayan, Da-Wen Sun, Hongbin Pu, Qingyi Wei
Summary: In this study, a novel plasmonic nanoparticles substrate with a mesoporous coating was synthesized for selective enhancement and detection of small molecules. The substrate showed high sensitivity and reproducibility, achieving the detection of chloramphenicol in milk samples. The addition of the mesoporous coating provided additional stability to the nanoparticles, allowing for substrate reusability.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Han-Wen Zhang, Qian-Qian Zhu, Rongrong Yuan, Hongming He
Summary: The UiO-66-NH2@COF composite, constructed through a covalent linking approach, significantly enhances the electrochemical detection performance, showing promising applications in the field.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Bo-Wei Du, Chih-Yuan Chu, Ching-Chang Lin, Fu-Hsiang Ko
Summary: Fe3O4@Au core-shell nanoparticles were found to serve as a multifunctional molecule delivery platform for sensing and carrying Doxorubicin (DOX) with a limit of detection of 1.839 nM. The Au nano-shell coating and specially designed DNA sequence allowed for efficient release of molecules under a high-frequency magnetic field. Moreover, increasing the thickness of the Au nano-shell enhanced the NP's surface area and reduced temperature increment, making it a potential future nanocarrier material. Overall, the core-shell NP structures proved to be controllable and efficient for molecule delivery.
Article
Chemistry, Multidisciplinary
Yanqing Hu, Shijie Yu, Xinyi Deng, Jiaqiang Zhou, Rui Zhang, Qiyue Shao
Summary: This research discovers the opposite temperature-dependence of upconversion luminescence (UCL) in active-shell and inert-shell nanocrystals. The UCL of active-shell nanocrystals is enhanced at elevated temperature, while the UCL of inert-shell nanocrystals declines. This phenomenon is mainly attributed to the gradually attenuated surface quenching effect induced by H2O molecules.
Article
Spectroscopy
Junlin Chen, Hong Lin, Limin Cao, Jianxin Sui, Lei Wang, Xiu Fang, Kaiqiang Wang
Summary: A portable surface-enhanced Raman scattering (SERS) aptasensor was developed for rapid on-site detection of chloramphenicol (CAP) residues in fish. The aptasensor utilized Fe3O4@Au nanoflowers as capture probes and Au@Ag NPs embedded with 4-mercaptobenzoic acid (4-MBA) as reporter probes. The SERS aptasensor showed excellent performance for CAP detection in fish samples, offering a promising portable analytical tool for drug residue analysis.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Physical
Van-Tuan Hoang, Lemma Teshome Tufa, Jaebeom Lee, Mai Quan Doan, Nguyen Ha Anh, Van Tan Tran, Anh-Tuan Le
Summary: This study investigates the surface-enhanced Raman spectroscopy (SERS) performance of Ag@Fe3O4 core-shell nanoparticles with different sizes. The smallest nanoparticles with thin shell and high shell porosity exhibit significantly improved mass diffusion and SERS performance, making them ideal substrates for highly sensitive detection of organic pollutants. Quantitative SERS measurements using the Ag@Fe3O4 nanoparticles were successfully demonstrated with methylene blue (MB) as probe analytes.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Analytical
Bing Liu, Hanyu Tang, Qian Liu, Wenwen Wang, Haitao Li, Shiya Zheng, Fei Sun, Xiangwei Zhao
Summary: In this study, a novel surface-enhanced Raman scattering-based Western blot (SERS-WB) was proposed for accurate quantitative detection of low-abundance proteins. SERS nanotags were used as quantitative labels of proteins, and the target protein on the membrane could be directly identified by colorimetric signal due to the aggregation effect of nanoparticles.
Article
Chemistry, Physical
Fengyang Jiang, Tian Lan, Jiaqiang Sun, Guofeng Zhao, Yong Lu
Summary: A highly efficient silica-encapsulated nano-Cu catalyst (Cu@SiO2/SiO2) was prepared via a complexation-impregnation method for the dehydrogenation of 1,6-hexanediol, exhibiting a 1,6-hexanediol conversion of 95.3% and ε-caprolactone selectivity of 80.0% at 270℃. The catalyst also showed outstanding thermal stability without sintering up to 270℃ for 100 hours on stream. This study is beneficial for designing high-performance Cu-based catalysts, understanding the reaction network, and large-scale production of ε-caprolactone.
Article
Nanoscience & Nanotechnology
Le Van Lich, Ha Thi Dang, Van-Hai Dinh
Summary: In this study, self-assembled toron structures were discovered in ferroelectric materials, which were formed due to combined effects of geometrical confinement and dipole interactions of different ferroelectric phases. Additionally, the chirality of the toron texture can be controlled by a homogeneous electric field. These findings may open up possibilities for novel solitonic polar structures and their technological applications.
SCRIPTA MATERIALIA
(2023)
Article
Engineering, Environmental
Ting Wang, Shuangpeng Wang, Zehua Cheng, Jinchao Wei, Lele Yang, Zhangfeng Zhong, Hao Hu, Yitao Wang, Bingpu Zhou, Peng Li
Summary: Pesticide residues pose a significant threat to human health and the environment, driving the need for rapid and effective detection methods. Core-shell nanostructures as novel SERS substrates have been widely utilized in rapid pesticide detection research. Understanding and monitoring pesticide residues can be improved through the classification and evaluation of different core-shell nanostructures and early-warning analysis.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Environmental
Ying Yang, Jian Zhu, Guo-jun Weng, Jian-jun Li, Jun-wu Zhao
Summary: The ingeniously designed penetrable nanoassemblies with Au ring satellites provide insights into the rational and optimal design of multifunctional nanostructures and expand the field of vision for the design of multifunctional sensing probes in biochemical detection.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Tsung-Shine Ko, Han-Yuan Liu, Jiann Shieh, De Shieh, Szu-Hung Chen, Yen-Lun Chen, En-Ting Lin
Summary: In this study, Si/MoS2 core/shell nanostructures were fabricated and characterized for SERS, showing significant enhancements in the SERS signal intensity for Rhodamine 6G (R6G) molecules. The larger interfaces provided by Si/MoS2 core/shell NP arrays were suggested to enhance the charge transfer process and exciton transitions, making them effective SERS substrates for biomedical detection.
Article
Chemistry, Analytical
Rui Gao, Dan Li, Qinmei Zhang, Siqing Zheng, Xingang Ren, Wei Deng
Summary: A new tri-mode method utilizing gold nanoparticles and quantum dots for on-site detection and discrimination of trinitrotoluene (TNT) was proposed in this study. The visualization of TNT detection was achieved through colorimetric, fluorescent, and Raman scattering responses, with good linearity and a low detection limit.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Nanoscience & Nanotechnology
Lan Thi Dang, Huy Le Nguyen, Hai Van Pham, Mai Thi Tuyet Nguyen
Summary: In this report, Au@Ag core-shell nanorod structures were developed for contaminants sensing by SERS. The silver shell thickness and plasmon wavelength were tuned by changing coating time and silver precursor amount. These structures showed ultra-sensitive detection ability for Nile blue A dye and Fenobucarb pesticide sensing. The Au@Ag core-shell sample with minimal silver shell thickness exhibited the highest Raman enhancement factor due to optimal enhancement of the electromagnetic field of bimetallic structures. This report demonstrates the potential applicability of combining unique features of two plasmonic metals in SERS-based analysis.
Article
Chemistry, Physical
Quan Doan Mai, Ha Anh Nguyen, Thi Lan Huong Phung, Ngo Xuan Dinh, Quang Huy Tran, Tri Quang Doan, Anh-Tuan Le
Summary: This study investigates the influence of energy levels and alignments of molecular orbitals on the charge transfer process and surface-enhanced Raman scattering (SERS) phenomenon. Experimental results show that the detection of antibiotics on electrochemically synthesized colloidal silver nanoparticles (e-AgNPs) as substrates differs due to the different energy levels of the antibiotics. The hypothesis is confirmed by testing other organic compounds. The study reveals a clear correlation between the energy level of analytes and their SERS signals.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Applied
Haizhou Wu, Shulan Xiao, Jie Yin, Jianhao Zhang, Mark P. Richards
Summary: The research shows that adding free fatty acids can inhibit lipid oxidation in meat, as well as forming hemichrome in hemoglobin by their interaction, which further reduces the oxidative capacity.
Article
Chemistry, Applied
Haizhou Wu, Shulan Xiao, Jie Yin, Jianhao Zhang, Mark P. Richards
Summary: The study revealed that muscle microstructure plays a critical role in lipid oxidation facilitated by myoglobin, while the degree of unsaturation in phospholipids has less impact. This suggests that the accessibility of myoglobin to phospholipids is crucial for lipid oxidation in muscle tissues.
Article
Food Science & Technology
Mehdi Abdollahi, Haizhou Wu, Ingrid Undeland
Summary: The study examined the impact of processing technology on protein recovery and nutrient content in fish backbones. Mechanical separation resulted in higher protein recovery, while pH-shift process effectively extracted protein from herring and salmon backbones. Processing methods also influenced the concentration of various nutrients in the recovered products.
Review
Food Science & Technology
Haizhou Wu, Mark P. Richards, Ingrid Undeland
Summary: This article discusses the principles, characteristics, and implementation of five novel antioxidant delivery methods in muscle-based foods. These methods include recyclable dipping solutions, encapsulation, cross-processing with nonmuscle antioxidant-containing raw materials, and applications of edible films/coatings and active packaging. The advantages of these technologies include low price, the possibility to control the antioxidant release rate, overcoming strong aromas from natural antioxidants, and valorizing antioxidant-containing raw materials from the food industry.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2022)
Article
Chemistry, Applied
Haizhou Wu, Bita Forghani, Mehdi Abdollahi, Ingrid Undeland
Summary: The study revealed that the head of herring showed the fastest lipid oxidation development, while the viscera + belly flap was the most stable part with the highest alpha-tocopherol content. Lipid oxidation susceptibility was significantly influenced by hemoglobin, lipoxygenases, and alpha-tocopherol, with no significant correlation found with total iron, copper, lipids, or polyunsaturated fatty acids.
Article
Chemistry, Applied
Haizhou Wu, Cecilia Tullberg, Semhar Ghirmai, Ingrid Undeland
Summary: The degradation and pro-oxidant activities of trout and bovine hemoglobin in washed cod muscle mince were studied. It was found that Hb degradation was more extensive in the gastric phase, and Hb promoted lipid oxidation.
Article
Chemistry, Applied
Nantawat Tatiyaborworntham, Fatih Oz, Mark P. Richards, Haizhou Wu
Summary: This article discusses the phenomenon of lipolysis in meat and meat products, particularly the hydrolysis of lipids through enzymatic catalysis. Lipolysis actively degrades triacylglycerols and phospholipids, resulting in the accumulation of free fatty acids and other hydrolytic products. It is commonly believed that lipolysis enhances lipid oxidation, leading to deterioration in meat quality and flavor development in certain meat products. However, recent studies have shown that in certain circumstances, lipolysis can inhibit lipid oxidation, providing insights into the mechanisms of lipid oxidation in muscle matrices and suggesting potential strategies for improving meat quality.
Review
Food Science & Technology
Haizhou Wu, Nantawat Tatiyaborworntham, Mahdi Hajimohammadi, Eric A. Decker, Mark P. Richards, Ingrid Undeland
Summary: This article reviews seven commonly used model systems for studying lipid oxidation in muscle-based foods, as well as the prospects of new technologies such as stem cells, tissue cultures, and three-dimensional printing.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Applied
Haizhou Wu, Jie Yin, Shulan Xiao, Jianhao Zhang, Mark P. Richards
Summary: The antioxidant effect of quercetin on Hb-mediated lipid oxidation was investigated. Quercetin effectively inhibited Hb-mediated lipid oxidation by reducing metHb and decreasing heme dissociation. Molecular docking revealed that quercetin became covalently bound to the a-chain of Hb through the formation of hydrogen bonds.
Article
Multidisciplinary Sciences
Semhar Ghirmai, Haizhou Wu, Michael Axelsson, Takashi Matsuhira, Hiromi Sakai, Ingrid Undeland
Summary: Hemoglobin promotes lipid oxidation in fish muscle, and limiting hemolysis can protect polyunsaturated fatty acids. This study found that bacterial growth, pH values, and Hb autoxidation play important roles in fish muscle hemolysis.
SCIENTIFIC REPORTS
(2022)
Review
Food Science & Technology
Haizhou Wu, Gabriel Oliveira, Mary Ann Lila
Summary: Color is an important characteristic of food. Anthocyanins, responsible for the purple, blue or red hues of many plants, not only offer market advantage but also show potential health benefits. However, the bioavailability of anthocyanins in the human body is low, and protein binding has been suggested as a strategy to enhance their bioactivity.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2023)
Review
Food Science & Technology
Haizhou Wu, Kathrine H. Bak, Gheorghe V. Goran, Nantawat Tatiyaborworntham
Summary: Lipid oxidation is a major cause of quality deterioration in muscle-based foods. Plant polyphenols, as natural antioxidants, can inhibit lipid oxidation in these foods through molecular interactions with proteins, phospholipid membranes, and reactive oxygen species.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Applied
Haizhou Wu, Sung Yong Park, Mark P. Richards
Summary: This study examined the effects of sodium chloride and sodium tripolyphosphate on lipid oxidation in washed turkey muscle, and found that sodium chloride promoted oxyhemoglobin-mediated lipid oxidation while sodium tripolyphosphate inhibited it.
Article
Chemistry, Applied
Haizhou Wu, Bita Forghani, Mehdi Abdollahi, Ingrid Undeland
Summary: This study investigated the weight distribution and nutritional composition of various cuts of herring obtained during the filleting process. The co-products were found to be rich in lipids, proteins, fatty acids, amino acids, minerals, and vitamins. The nutritional value of the co-products was often higher than that of the fillet, making them excellent sources for functional food and nutraceuticals.
Meeting Abstract
Chemistry, Applied
Chairs Lan Ban, Karen Schaich, Mark Richards, Haizhou Wu, Nantawat Tatiyabororntham
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2021)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
