Article
Chemistry, Analytical
Ahmed Faried Abdel Hakiem, Idoia Urriza-Arsuaga, Javier L. Urraca
Summary: An accurate and simple screening method has been developed to determine fluoroquinolone antibiotics using carbon dots as highly fluorescent nano-sensors. The method involves the synthesis of organic-based molecularly imprinted polymers and the development of fluorescence-based polymeric composites. The method showed efficient quenching of fluorescence and good correlation with other fluoroquinolones. It was successfully applied for the determination of enrofloxacin in different meat samples.
Review
Chemistry, Analytical
Myriam Diaz-Alvarez, Antonio Martin-Esteban
Summary: This paper reviews the development of optical sensors using a combination of quantum dots and molecularly imprinted polymers. These sensors overcome the limitations of traditional analytical methods and improve sensor selectivity and sensitivity.
Article
Biochemistry & Molecular Biology
Xiaoxiao Chen, Yang Liu, Pu Li, Yichen Xing, Chaobiao Huang
Summary: A method for the trace detection of chloramphenicol (CAP) was established using a dual recognition system with a fluorescence quenching of quantum dots (QDs) and specific recognition of molecularly imprinted polymer (MIP). The MIP@SiO2@QDs showed good detection selectivity for CAP and was successfully applied to quantify CAP in lake water with promising potential for on-site detection in environmental waters.
Review
Chemistry, Analytical
Ruoyang Liu, Chi-Chiu Ko
Summary: MIP-based luminescent chemosensors have been widely studied due to their high specificity and sensitivity in molecular recognition and luminescence detection. Different strategies, including incorporation of luminescent functional monomers and surface-imprinting polymerization on luminescent nanomaterials, have been used to construct luminescent MIPs for various analytes. This review discusses the design strategies, sensing approaches, and applications of luminescent MIP-based chemosensors in biosensing, bioimaging, food safety, and clinical diagnosis, as well as the limitations and prospects for future development.
Article
Chemistry, Analytical
Tianhao Li, Zhiwei Deng, Jiaqi Bu, Hui Liu, Yanjing Yang, Shian Zhong
Summary: A test strip for selective detection of ferritin was developed by integrating molecular imprinting technology and multicolor fluorescence elements. The test strip showed high specificity for ferritin and allowed for rapid and visual detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Li Liu, Maomin Peng, Ke Xu, Hong Xia, Xitian Peng, Lijun Peng, Jin Z. Zhang
Summary: Molecularly imprinted polymers with methylammonium lead halide perovskite quantum dots were prepared and used for the determination of benzo(a)pyrene. The interaction between MIP@MAPbBr(3) PQDs and BaP is a dynamic process, enhancing the PL intensity. The molecularly imprinted fluorescence assay shows good specificity and selectivity for BaP in complex mixtures.
Article
Materials Science, Biomaterials
Jixiang Wang, Xiaolei Li, Rong Zhang, Bingjie Fu, Mingcan Chen, Mengxue Ye, Wanyu Liu, Jingjing Xu, Guoqing Pan, Hongbo Zhang
Summary: In this study, a fluorescent sensor based on molecularly imprinted magnetic hahoysite nanotubes (MHNTs@FMIP5) was designed and synthesized for the effective detection and purification of OTC in actual environmental samples. The sensor exhibited low detection limit, excellent specificity, and potential applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Physical
Amir Amiri, Farnoush Faridbod, Sheida Zoughi
Summary: A novel optical nanosensor based on carbon dots embedded in silica was developed for sensitive detection of ceftazidime. The sensor showed strong fluorescence emission and quenched in the presence of ceftazidime molecules. It exhibited a linear response to ceftazidime concentration with low detection limit and small relative standard deviation.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Chemistry, Analytical
Dounia Elfadil, Sara Palmieri, Flavio Della Pelle, Manuel Sergi, Aziz Amine, Dario Compagnone
Summary: This study presents a novel method combining molecularly imprinted polymers (MIPs) and enzymatic inhibition assay for the selective and sensitive determination of acetazolamide (ACZ) in biological samples. The MIPs were synthesized using ACZ as the template molecule and were used as the sorbent phase in dispersive solid-phase extraction (MIPs-dSPE). The developed method showed good recovery and correlation with LC-MS/MS analysis, providing a selective and quantitative approach for the determination of ACZ.
Review
Chemistry, Analytical
Saeedeh Ansari, Saeed Masoum
Summary: This article mainly focuses on the design, sensing mechanisms, and properties of MIP/CDs-based fluorescent sensors in recent years, highlighting the importance and potential value of MIP/CDs in sensing systems.
Article
Environmental Sciences
Jin-Jie You, Hua Liu, Rong-Rong Zhang, Qiao-Fen Pan, Ai-Li Sun, Ze-Ming Zhang, Xi-Zhi Shi
Summary: A tricolor ratiometric fluorescence sensor was developed using molecularly imprinted quantum dots and quantum dots. It showed a wider range of color variations for visual DBP detection and had comparable results to gas chromatography-tandem mass spectrometry.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Applied
Yunyan Ren, Zhefeng Fan
Summary: In this study, nitrogen-doped carbon dot-based molecularly imprinted polymers (N-CDs@MIPs) were successfully prepared for the trace analysis of tobramycin in milk. The probe showed high sensitivity and selectivity compared to other techniques and can be an alternative method for the detection of tobramycin.
Article
Chemistry, Analytical
Roghayeh Mantashloo, Soleiman Bahar
Summary: In this study, modified magnetic graphene quantum dots with molecularly imprinted polymer coating (Fe3O4@GQDs/MIP), which serve as a low-cost green adsorbent for easy evaluation of quercetin medicinal compound, were synthesized. The optimal conditions for measuring quercetin were investigated, and quercetin in real samples of green tea, cumin, and thyme was successfully measured and detected. The synthesized adsorbent showed high selectivity, sensitivity, and efficiency.
MICROCHEMICAL JOURNAL
(2023)
Article
Spectroscopy
Manal A. Alossaimi, Abdulmalik S. A. Altamimi, Heba Elmansi, Galal Magdy
Summary: A new spectrofluorimetric method based on nitrogen-doped carbon quantum dots (N-CQDs) fluorescent probes was proposed for the determination of larotrectinib. The method is simple, involves no pre-treatment steps or complicated techniques, and showed sufficient sensitivity for the analysis of the drug. The synthesized N-CQDs exhibited high fluorescence intensity, allowing for the selective quenching and sensitive determination of larotrectinib.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Review
Chemistry, Analytical
Rustem Kecili, Chaudhery Ghazanfar Hussain, Chaudhery Mustansar Hussain
Summary: This paper summarises the recent developments in the fabrication of MIPs-coated green CDs as powerful sensing platforms for the determination of various compounds in complex samples (i.e. biological, food and environmental matrices).
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Biophysics
Hui Niu, Yaqiong Yang, Huiqi Zhang
BIOSENSORS & BIOELECTRONICS
(2015)
Article
Nanoscience & Nanotechnology
Yaqiong Yang, Hui Niu, Huiqi Zhang
ACS APPLIED MATERIALS & INTERFACES
(2016)
Article
Biophysics
Ya-Qiong Yang, Xi-Wen He, Yi-Zhi Wang, Wen-You Li, Yu-Kui Zhang
BIOSENSORS & BIOELECTRONICS
(2014)
Article
Chemistry, Analytical
Yaqiong Yang, Xiaoping Qian, Lihui Zhang, Wenjun Miao, Dengming Ming, Ling Jiang, He Huang
ANALYTICA CHIMICA ACTA
(2020)
Article
Chemistry, Analytical
Xinliu Tan, Xueqing Wang, Aiyue Hao, Yifan Liu, Xuepei Wang, Teng Chu, Ling Jiang, Yaqiong Yang, Dengming Ming
MICROCHEMICAL JOURNAL
(2020)
Article
Spectroscopy
Ai-Yue Hao, Xue-Qing Wang, Yan-Zhen Mei, Jun-Fang Nie, Ya-Qiong Yang, Chuan-Chao Dai
Summary: The smartphone-combined dual-emission ratiometric fluorescence probe is designed for specifically and visibly detecting cephalexin, providing a good linear response and low detection limit. It is also applicable for determining the amount of cephalexin in milk samples with high recovery rate.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Polymer Science
Yiting Li, Lihui Zhang, Youhong Shi, Jialing Huang, Yaqiong Yang, Dengming Ming
Article
Nanoscience & Nanotechnology
Xueqing Wang, Lihui Zhang, Aiyue Hao, Ziying Shi, Chuanchao Dai, Yaqiong Yang, He Huang
ACS APPLIED NANO MATERIALS
(2020)
Article
Materials Science, Multidisciplinary
Yiting Li, Xiaoping Qian, Xinliu Tan, Xinghua Liu, Yang Li, Dengming Ming, Lihui Zhang, Yaqiong Yang
ACS APPLIED POLYMER MATERIALS
(2020)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)