Article
Integrative & Complementary Medicine
Liu Chunhua, Lu Dingyan, You Jingrui, Lu Yuan, Sun Jia, Pan Jie, Wang Yonglin, Wang Aimin, Lan Yanyu, Li Yongjun, Liu Ting
Summary: WF protects H9c2 myocardial cells from oxidative stress and apoptosis induced by H2O2 by scavenging ROS, enhancing antioxidant capacity, protecting mitochondria, and regulating apoptosis-related protein expression.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yi Shen, Zheng Shen, Ping Li, Zhangrong Chen, Bo Wei, Danan Liu, Xiaoyun Si, Jiayi Pan, Daiqin Wu, Wei Li
Summary: In this study, the anti-oxidation capacity of Malus doumeri leaf extract (MDLE) was tested. The results showed that MDLE has significant scavenging effects on various radicals and can protect myocardial cells from oxidative damage. The main active components of MDLE were identified as chlorogenic acid, isoquercitrin, quercetin, baicalin, and phloretin.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Food Science & Technology
Xinyue Peng, Luyi Tan, Jia Song, Yuefei Lai, Susu Yu, Feifei Xu, Qinzhi Wei, Zhini He, Wenli Cheng, Wenjuan Zhang, Xingfen Yang
Summary: Geniposide (GP) has anti-apoptotic effects on human hepatocyte L-02 cells induced by hydrogen peroxide (H2O2), and it regulates the global DNA methylation level and expression changes of specific genes to inhibit apoptosis.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Reproductive Biology
Haoze Wu, Nanwei Ye, Zhenwu Huang, Kun Lei, Fangxiong Shi, Quanwei Wei
Summary: This study aimed to investigate the effects of dietary curcumin supplementation on hydrogen peroxide (H2O2)-induced testicular oxidative damage in breeder roosters. The results showed that curcumin supplementation improved semen quality and testicular morphology, increased testosterone levels, and enhanced antioxidant capacities. Moreover, curcumin reversed the negative effects of H2O2 on spermatogenesis-related genes, antioxidant genes, and protein expressions, and normalized mRNA expressions of specific genes. In conclusion, dietary curcumin supplementation alleviates H2O2-induced oxidative damage and reproduction decline through the Nrf2 signaling pathway and anti-apoptotic effects.
Article
Agriculture, Dairy & Animal Science
Shuai Chen, Xin Wu, Jielin Duan, Pan Huang, Tiejun Li, Yulong Yin, Jie Yin
Summary: The study demonstrated that low-protein diets supplemented with glutamic acid or aspartic acid can improve oxidative stress-induced intestinal dysfunction in weaned piglets by reducing oxidative stress-related protein expression, lowering serum diamine oxidase levels, inhibiting intestinal epithelial cell apoptosis, alleviating abnormal energy metabolism, and maintaining intestinal barrier integrity.
Article
Chemistry, Analytical
Fanny Girard-Sahun, Pauline Lefrancois, Vasilica Badets, Stephane Arbault, Franck Clement
Summary: This study aims to detect the in situ production of reactive oxygen and nitrogen species (RONS), specifically superoxide anion (O-2(center dot-)), in aqueous buffer solutions exposed to cold atmospheric plasmas (CAPs). The production and accumulation of RONS in the liquids were found to depend on the plasma composition, with N-2-based shieldings providing the highest concentrations of superoxide. The study provides valuable insights into the interactions between CAPs and physiological solutions for biomedical applications.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Sopita Rattanopas, Albert Schulte, Somjai Teanphonkrang
Summary: In this study, effective amperometric sensors for cathodic hydrogen peroxide (H2O2) detection were produced and characterized, demonstrating good linearity and high sensitivity. The combination of PB/CNT layer and gelatin/zein layer in a sandwich-type sensor proved to be successful, providing accurate detection of H2O2 concentrations in model and real samples. The sensors are cost-effective, easy to make, and can be used for electrochemical H2O2 analyses in various applications.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xinyu Li, Qing Yang, Fangli Yi, Yiqi Yuan, Hongmei Cao, Kewei Liu, Hongjian Yan
Summary: The crystallinity of semiconductors is crucial for enhancing the separation and transportation of photogenerated carriers and their photocatalytic performance. However, organic semiconductors have lower crystallinity compared to inorganic semiconductors. In this study, a novel strategy was proposed to improve the crystallinity of the fluorinated imine-linked covalent organic framework, TFA-TaPt-COF, by forming acetal between the aldehyde and ethanol. The TFA-TaPt-COF with higher crystallinity showed a broader absorption edge up to 650 nm, lower photoluminescence intensity, and a 5 times higher photocatalytic H2O2 evolution rate compared to the one synthesized without using alcohol.
Article
Chemistry, Medicinal
Ramona Meanti, Laura Rizzi, Elena Bresciani, Laura Molteni, Vittorio Locatelli, Silvia Coco, Robert John Omeljaniuk, Antonio Torsello
Summary: Hexarelin displays inhibitory effects on H2O2-induced apoptosis in Neuro-2A cells, improving cell viability, reducing NO2- release, restoring cell morphology, and modulating apoptotic gene expression and protein kinase phosphorylation levels.
Article
Biochemistry & Molecular Biology
Zhongyuan Tang, Zonghui Zhang, Jiaqi Wang, Zhengwu Sun, Eskandar Qaed, Xinming Chi, Jun Wang, Yazeed Jamalat, Zhaohong Geng, Zeyao Tang, Qiying Yao
Summary: Phosphocreatine (PCr) can suppress H2O2-induced apoptosis in endothelial cells and reduce hyperlipidemia by inhibiting ROS generation and modulating the dysfunctional mitochondrial system, which might be an effective new therapeutic strategy to prevent atherosclerosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Multidisciplinary Sciences
Jaeho Yoon, Hanhwi Jang, Min-Wook Oh, Thomas Hilberath, Frank Hollmann, Yeon Sik Jung, Chan Beum Park
Summary: The authors demonstrate the direct conversion of low-grade waste heat into chemical energy using a combination of thermoelectric materials and biocatalysts. The results show that thermoelectric materials, such as bismuth telluride, can efficiently convert low-temperature waste heat into chemical energy and promote oxyfunctionalization reactions. This study highlights the feasibility of thermoelectrobiocatalysis in utilizing low-quality waste heat for practical applications.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Shaoda Huang, Bingyan Zhang, Huimin Sun, Hongyin Hu, Jinyan Wang, Fang Duan, Han Zhu, Mingliang Du, Shuanglong Lu
Summary: We developed a series of single atom catalysts anchored on bipyridine-rich COFs. The optimal Py-Bpy-COF-Zn shows the highest selectivity of 99.1% and excellent stability in H2O2 production via oxygen reduction, attributed to its high *OOH dissociation barrier. As a proof of concept, it acts as a cathodic catalyst in a homemade Zn-air battery and enables efficient wastewater treatment.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Cunli Wang, Yiming Yang, Shuai Shao, Hangyu Zhang, Na Li, Zhengyao Zhang, Bo Liu
Summary: We have developed a ROS sensor based on modified nanopores GGGCEG(GPGGA)(4)CEG. The formation of an intramolecular disulfide bond oxidized by ROS leads to conformation changes in GGGCEG(GPGGA)(4)CEG, which then induces a noticeable change in the size of the nanopores and the corresponding ionic current. This work enables accurate and dynamic monitoring of ROS through the combination of (GPGGA)(4) and nanopores.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Peng Hu, Shuang Zhao, Jiahua Shi, Fan Li, Shaochen Wang, Ying Gan, Lei Liu, Shuling Yu
Summary: A dual-responsive HMPDA@Cu2-xSe cascade catalytic nanoplatform was constructed for efficient photothermal therapy and controlled drug release. The nanoplatform showed significant tumor cell inhibition effect in vitro and in vivo, demonstrating its potential for effective multi-modal combination therapy for tumors.
Article
Chemistry, Multidisciplinary
Demin Kong, Lei Wang, Xiaoqian Chen, Wei Xia, Lingqia Su, Fangyuan Zuo, Zhengfei Yan, Sheng Chen, Jing Wu
Summary: This study proposes a new method for the degradation of polyethylene by introducing lipase and cutinase, which effectively reduces the molecular weight of polyethylene.