Article
Physiology
Kris Nilsen, Bruce R. Thompson, Natalie Zajakovski, Michael Kean, Benjamin Harris, Gary Cowin, Phil Robinson, G. Kim Prisk, Francis Thien
Summary: The study utilized He-3 MRI to investigate lung function in asthma patients and found that the areas of low-ventilated lung in asthma patients were primarily due to airway closure. The marker of airway closure Xrs (6 Hz) was a significant predictor of low-ventilated lung volume.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Pediatrics
W. Gerald Teague, Jaime Mata, Kun Qing, Nicholas J. Tustison, John P. Mugler, Craig H. Meyer, Eduard E. de Lange, Yun M. Shim, Kristin Wavell, Talissa A. Altes
Summary: In this study, HHe-3 MR imaging was used to analyze 60 children with asthma, finding that VH indicators were significantly associated with inflammatory markers and could serve as a way to identify severe phenotypes.
PEDIATRIC PULMONOLOGY
(2021)
Article
Multidisciplinary Sciences
Marvin Petersen, Felix Leonard Naegele, Carola Mayer, Maximilian Schell, Elina Petersen, Simone Kuehn, Juergen Gallinat, Jens Fiehler, Ofer Pasternak, Jakob Matschke, Markus Glatzel, Raphael Twerenbold, Christian Gerloff, Goetz Thomalla, Bastian Cheng
Summary: Through comprehensive neuroimaging and neuropsychological assessments of 223 nonvaccinated individuals recovered from a mild to moderate SARS-CoV-2 infection, it was found that there were significant differences in measures of white matter microstructure between the post-SARS-CoV-2 group and the matched controls. However, a mild to moderate SARS-CoV-2 infection was not associated with neuropsychological deficits, significant changes in cortical structure, or vascular lesions several months after recovery.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Physiology
Katherine J. Carey, Peter Hotvedt, David G. Mummy, Kristine E. Lee, Loren C. Denlinger, Mark L. Schiebler, Ronald L. Sorkness, Nizar N. Jarjour, Charles R. Hatt, Craig J. Galban, Sean B. Fain
Summary: The purpose of this study was to correlate ventilation defects with air trapping in the context of airway mucus plugging in asthma. The results showed that ventilation defects were moderately correlated with functional small airways disease (fSAD) and mucus plugging. This suggests that ventilation defects and fSAD are sensitive to specific sources of airway obstruction in asthma, including mucus plugs.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Respiratory System
Wang Chun Kwok, Terence Chi Chun Tam, David Chi Leung Lam, Jackson Ka Chun Leung, King Pui Florence Chan, Shung Kay Samuel Chan, Ka Yan Chiang, Mary Sau Man Ip, James Chung Man Ho
Summary: A case control study found that mild-to-moderate COVID-19 has a negative impact on asthma control in patients, including worsening symptoms, decreased ACT scores, increased need for asthma maintenance therapy, and poorer asthma control.
RESPIRATORY RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sarah Svenningsen, Marrissa McIntosh, Alexei Ouriadov, Alexander M. Matheson, Norman B. Konyer, Rachel L. Eddy, David G. McCormack, Michael D. Noseworthy, Parameswaran Nair, Grace Parraga
Summary: The study aimed to evaluate the reproducibility and agreement of (129Xe) ventilation MRI measurements in severe asthmatics at two sites. The results showed that Xe-129 MRI VDP measured at two different sites within 24-hours in the same severe asthmatics were correlated, despite qualitative and quantitative intersite differences in Xe-129 regional gas distribution and VDP.
ACADEMIC RADIOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Sarah E. Gray, Adam S. Cifu, Valerie G. Press
Summary: This article summarizes a guideline on the prevention and treatment of mild to moderate asthma, produced by the Global Initiative for Asthma (GINA).
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Neurosciences
Ling Yue, Dan Hu, Han Zhang, Junhao Wen, Ye Wu, Wei Li, Lin Sun, Xia Li, Jinghua Wang, Guanjun Li, Tao Wang, Dinggang Shen, Shifu Xiao
Summary: By using neuroimaging and machine learning models, the progression from SCD to MCI in high-risk individuals can be predicted, with identified factors influencing the progression. This study provides important insights for future neuropathological research on AD.
HUMAN BRAIN MAPPING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
James T. Grist, Mitchell Chen, Guilhem J. Collier, Betty Raman, Gabriele Abueid, Anthony McIntyre, Violet Matthews, Emily Fraser, Ling-Pei Ho, Jim M. Wild, Fergus Gleeson
Summary: The study found that patients had breathlessness 3 months after discharge following COVID-19 infection, and hyperpolarized xenon 129 MRI imaging showed alveolar capillary diffusion limitation, despite normal or nearly normal CT results.
Article
Medicine, General & Internal
Leonard B. Bacharier, Jorge F. Maspero, Constance H. Katelaris, Alessandro G. Fiocchi, Remi Gagnon, Ines de Mir, Neal Jain, Lawrence D. Sher, X. Mao, D. Liu, Yi Zhang, Asif H. Khan, Upender Kapoor, Faisal A. Khokhar, Paul J. Rowe, Yamo Deniz, Marcella Ruddy, Elizabeth Laws, Naimish Patel, David M. Weinreich, George D. Yancopoulos, Nikhil Amin, Leda P. Mannent, David J. Lederer, Megan Hardin
Summary: This study showed that among children aged 6 to 11 with uncontrolled moderate-to-severe asthma, those who received add-on dupilumab had fewer asthma exacerbations, better lung function and asthma control compared to those who received placebo.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Respiratory System
Kamel Alachraf, Caroline Currie, William Wooten, Dmitry Tumin
Summary: This study investigated the impact of social determinants of health on emergency department use among children with different severities of asthma. The results showed that these factors were equally predictive of ED use regardless of asthma severity.
Article
Immunology
Malgorzata Proboszcz, Krzysztof Goryca, Patrycja Nejman-Gryz, Tadeusz Przybylowski, Katarzyna Gorska, Rafal Krenke, Magdalena Paplinska-Goryca
Summary: The study investigated distinct disease profiles based on clinical, cellular, and molecular data from patients with mild-to-moderate obstructive pulmonary diseases. Five key variables were identified to differentiate between asthma and COPD, and cluster analysis revealed two main clusters within the combined samples of asthma and COPD patients.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Chiara Maria Lo Feudo, Luca Stucchi, Elena Alberti, Bianca Conturba, Enrica Zucca, Francesco Ferrucci
Summary: Equine asthma is a respiratory syndrome similar to human asthma, with mild-moderate and severe classifications. Environmental allergens trigger hypersensitivity responses in asthmatic horses, with insects, Dermatophagoides spp., and dog epithelium being the most common allergens. Type-I hypersensitivity plays a major role in severe equine asthma, while type-IV hypersensitivity is more involved in milder forms. Intradermal testing is effective in identifying hypersensitivity to specific allergens in equine medicine.
Review
Allergy
Hacer Ilbilge Ertoy Karagol, Arzu Bakirtas
Summary: This article discusses the prevalence of mild to moderate asthma in children and the classification of mild and moderate asthma according to different guidelines. While previous studies have mainly focused on the management of severe asthma, there have been important improvements in the management of mild to moderate asthma as well.
JOURNAL OF ASTHMA AND ALLERGY
(2021)
Article
Respiratory System
Jefferson Antonio Buendia, Diana Guerrero Patino
Summary: The study concludes that low-dose budesonide-formoterol as a reliever is cost-effective for patients with mild asthma, with potential gain in quality-adjusted life-years and reduced costs compared to maintenance ICS therapy. The results were robust in sensitivity analyses, suggesting that this approach could be beneficial for improving clinical practice guidelines and should be validated in other middle-income countries.
BMC PULMONARY MEDICINE
(2021)