Journal
PSYCHIATRY RESEARCH
Volume 284, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2019.112670
Keywords
Post-stroke depression; Anti-depressive therapies; Prevention; Meta-analysis
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Funding
- Medical Scientific Research Foundation of Guangdong Province of China [A2019392]
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To explore the necessity and feasibility of early anti-depressive therapies in acute stroke patients, we conducted a meta-analysis of currently available randomized control studies (RCTs). Literature search in six databases was done with keywords of cerebrovascular accident, depression and prevention. Only RCTs that met the inclusion criteria were enrolled for further analysis. Twelve eligible studies were included in this meta-analysis. Prophylactic anti-depressive therapies following acute stroke were shown to reduce the incidence of depression in the patients (RR = =0.33, 95% CI: 0.25 to 0.43, p < 0.001), improve symptoms of depression (WMD: 5.73, 95% CI: 4.18 to 7.29, p < 0.001), improve motor function (WMD: 12.56, 95%Cl: 9.07 to 16.04,p < 0.001) and neurological function (WMD: 1.13, 95,/oCI: 0.57 to 1.69,p < 0.001). However, anti-depressive therapies showed no effects on mortality (RR = 1.63, 95%CI: 0.55 to 4.85, p = 0.377) and adverse events incidence (RR = 0.93, 95%CI: 0.53 to 1.64,p = 0.806). Anti-depressive therapies following acute stroke is effective thus deserves to be advocated.
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