Gene drive for population genetic control: non-functional resistance and parental effects

Molecular safeguarding of CRISPR gene drive experiments

(2019) Jackson Champer et al.   eLife

CRISPR Gene Drive Efficiency and Resistance Rate Is Highly Heritable with No Common Genetic Loci of Large Effect

(2019) Jackson Champer et al.   GENETICS

Modelling the potential of genetic control of malaria mosquitoes at national scale

(2019) Ace R. North et al.   BMC BIOLOGY

Efficient allelic-drive in Drosophila

(2019) Annabel Guichard et al.   Nature Communications

Reducing resistance allele formation in CRISPR gene drive

(2018) Jackson Champer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes

(2018) Kyros Kyrou et al.   NATURE BIOTECHNOLOGY

Behavior of homing endonuclease gene drives targeting genes required for viability or female fertility with multiplexed guide RNAs

(2018) Georg Oberhofer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-limiting population genetic control with sex-linked genome editors

(2018) Austin Burt et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Gene drives to fight malaria: current state and future directions

(2017) Andrew M. Hammond et al.   Pathogens and Global Health

Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations

(2017) Jackson Champer et al.   PLoS Genetics

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito

(2017) Andrew M. Hammond et al.   PLoS Genetics

Overcoming evolved resistance to population-suppressing homing-based gene drives

(2017) John M. Marshall et al.   Scientific Reports

Evolution of Resistance Against CRISPR/Cas9 Gene Drive

(2016) Robert L. Unckless et al.   GENETICS

Impact of mosquito gene drive on malaria elimination in a computational model with explicit spatial and temporal dynamics

(2016) Philip A. Eckhoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of Resistance Against CRISPR/Cas9 Gene Drive

(2016) Robert L. Unckless et al.   GENETICS

A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae

(2015) Andrew Hammond et al.   NATURE BIOTECHNOLOGY

Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquitoAnopheles stephensi

(2015) Valentino M. Gantz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A synthetic sex ratio distortion system for the control of the human malaria mosquito

(2014) Roberto Galizi et al.   Nature Communications

Requirements for effective malaria control with homing endonuclease genes

(2011) A. Deredec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The vasa regulatory region mediates germline expression and maternal transmission of proteins in the malaria mosquito Anopheles gambiae: a versatile tool for genetic control strategies

(2009) Philippos A Papathanos et al.   BMC MOLECULAR BIOLOGY

The Population Genetics of Using Homing Endonuclease Genes in Vector and Pest Management

(2008) A. Deredec et al.   GENETICS

Targeting the X Chromosome during Spermatogenesis Induces Y Chromosome Transmission Ratio Distortion and Early Dominant Embryo Lethality in Anopheles gambiae

(2008) Nikolai Windbichler et al.   PLoS Genetics