Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 116, Issue 47, Pages 23437-23443Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1911869116
Keywords
photodynamic inactivation; bacteria; membrane-intercalating; virus coat protein; aggregation-induced emission
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Funding
- National Key R&D Program of China [2018YFC1105300]
- Beijing Natural Science Foundation [7182110]
- National Natural Science Foundation of China [21474123, 51703230, 21901161]
- Youth Innovation Promotion Association of the Chinese Academy of Sciences [2017039]
- Presidential Foundation of Technical Institute of Physics and Chemistry
- Program for Eastern Scholar of Shanghai
- Shanghai Jiao Tong University
- NIH [R01 CA215157]
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Antibiotic resistance has become one of the major threats to global health. Photodynamic inactivation (PDI) develops little antibiotic resistance; thus, it becomes a promising strategy in the control of bacterial infection. During a PDI process, light-induced reactive oxygen species (ROS) damage the membrane components, leading to the membrane rupture and bacteria death. Due to the short half-life and reaction radius of ROS, achieving the cell-membrane intercalation of photosensitizers is a key challenge for PDI of bacteria. In this work, a tetraphenylethylenebased discrete organoplatinum(II) metallacycle (1) acts as a photosensitizer with aggregation-induced emission. It self-assembles with a transacting activator of transduction (TAT) peptide-decorated virus coat protein (2) through electrostatic interactions. This assembly (3) exhibits both ROS generation and strong membrane-intercalating ability, resulting in significantly enhanced PDI efficiency against bacteria. By intercalating in the bacterial cell membrane or entering the bacteria, assembly 3 decreases the survival rate of gram-negative Escherichia coli to nearly zero and that of gram-positive Staphylococcus aureus to similar to 30% upon light irradiation. This study has wide implications from the generation of multifunctional nano-materials to the control of bacterial infection, especially for gramnegative bacteria.
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