Repression of eEF2K transcription by NF-κB tunes translation elongation to inflammation and dsDNA-sensing

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan

(2019) Jianling Xie et al.   CURRENT BIOLOGY

Polyamine Control of Translation Elongation Regulates Start Site Selection on Antizyme Inhibitor mRNA via Ribosome Queuing

(2018) Ivaylo P. Ivanov et al.   MOLECULAR CELL

Translation Elongation and Recoding in Eukaryotes

(2018) Thomas E. Dever et al.   Cold Spring Harbor Perspectives in Biology

Translational Control in Virus-Infected Cells

(2018) Noam Stern-Ginossar et al.   Cold Spring Harbor Perspectives in Biology

Protein Synthesis Initiation in Eukaryotic Cells

(2018) William C. Merrick et al.   Cold Spring Harbor Perspectives in Biology

Phosphorylation and Signal Transduction Pathways in Translational Control

(2018) Christopher G. Proud   Cold Spring Harbor Perspectives in Biology

mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation

(2018) Thomas Karonitsch et al.   Cell Reports

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

(2018) Xiaojun Tan et al.   Annual Review of Microbiology

Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing

(2017) Christopher Bianco et al.   JOURNAL OF VIROLOGY

Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy

(2017) William D Rawlinson et al.   LANCET INFECTIOUS DISEASES

The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation

(2017) Matous Hrdinka et al.   MOLECULAR CELL

The UPR ER : Sensor and Coordinator of Organismal Homeostasis

(2017) Ashley E. Frakes et al.   MOLECULAR CELL

Tumor Necrosis Factor dynamically regulates the mRNA stabilome in rheumatoid arthritis fibroblast-like synoviocytes

(2017) Konstantinos Loupasakis et al.   PLoS One

Pharmacological eEF2K activation promotes cell death and inhibits cancer progression

(2016) Aude De Gassart et al.   EMBO REPORTS

Cancer and inflammation

(2016) Lance L. Munn   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

p53 and the Carcinogenicity of Chronic Inflammation

(2016) Andrei V. Gudkov et al.   Cold Spring Harbor Perspectives in Medicine

A Cap-to-Tail Guide to mRNA Translation Strategies in Virus-Infected Cells

(2016) Eric Jan et al.   Annual Review of Virology

Programmed Necrosis in the Cross Talk of Cell Death and Inflammation

(2015) Francis Ka-Ming Chan et al.   Annual Review of Immunology

Regulation and roles of elongation factor 2 kinase

(2015) Christopher G. Proud   BIOCHEMICAL SOCIETY TRANSACTIONS

Pausing on Polyribosomes: Make Way for Elongation in Translational Control

(2015) Joel D. Richter et al.   CELL

TNF biology, pathogenic mechanisms and emerging therapeutic strategies

(2015) George D. Kalliolias et al.   Nature Reviews Rheumatology

TNF-α–stimulated fibroblasts secrete lumican to promote fibrocyte differentiation

(2015) Darrell Pilling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Crosstalk between fibroblasts and inflammatory cells

(2014) S. Van Linthout et al.   CARDIOVASCULAR RESEARCH

A Bicistronic MAVS Transcript Highlights a Class of Truncated Variants in Antiviral Immunity

(2014) Sky W. Brubaker et al.   CELL

Host Cell Polarity Proteins Participate in Innate Immunity to Pseudomonas aeruginosa Infection

(2014) Cindy S. Tran et al.   Cell Host & Microbe

Global Reprogramming of the Cellular Translational Landscape Facilitates Cytomegalovirus Replication

(2014) Caleb McKinney et al.   Cell Reports

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation

(2013) Gabriel Leprivier et al.   CELL

Coordinated regulation of synthesis and stability of RNA during the acute TNF-induced proinflammatory response

(2013) M. T. Paulsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nutrient Signaling in Protein Homeostasis: An Increase in Quantity at the Expense of Quality

(2013) C. S. Conn et al.   Science Signaling

Host Translation at the Nexus of Infection and Immunity

(2012) Ian Mohr et al.   Cell Host & Microbe

Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis

(2012) Bárbara González-Terán et al.   JOURNAL OF CLINICAL INVESTIGATION

Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E

(2012) Barbara Herdy et al.   NATURE IMMUNOLOGY

ENCODE Data in the UCSC Genome Browser: year 5 update

(2012) Kate R. Rosenbloom et al.   NUCLEIC ACIDS RESEARCH

Poly(A) binding protein abundance regulates eukaryotic translation initiation factor 4F assembly in human cytomegalovirus-infected cells

(2012) C. McKinney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coupled Activation and Degradation of eEF2K Regulates Protein Synthesis in Response to Genotoxic Stress

(2012) F. Kruiswijk et al.   Science Signaling

The p65 Subunit of NF-κB InhibitsCOL1A1Gene Transcription in Human Dermal and Scleroderma Fibroblasts through Its Recruitment on Promoter by Protein Interaction with Transcriptional Activators (c-Krox, Sp1, and Sp3)

(2011) Gallic Beauchef et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytomegalovirus: pathogen, paradigm, and puzzle

(2011) Michael Boeckh et al.   JOURNAL OF CLINICAL INVESTIGATION

The Role of Nuclear Factor κB in the Interferon Response

(2011) Lawrence M. Pfeffer   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The quantitative proteome of a human cell line

(2011) M. Beck et al.   Molecular Systems Biology

Interferon-stimulated genes and their antiviral effector functions

(2011) John W Schoggins et al.   Current Opinion in Virology

Cytomegalovirus in Hematopoietic Stem Cell Transplant Recipients

(2010) Per Ljungman et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection

(2010) Michael J. Cannon et al.   REVIEWS IN MEDICAL VIROLOGY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

TNF-α increases protein content in C2C12 and primary myotubes by enhancing protein translation via the TNF-R1, PI3K, and MEK

(2007) Isabelle Plaisance et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM