Journal
POLYMER DEGRADATION AND STABILITY
Volume 168, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymdegradstab.2019.108956
Keywords
Supramolecular polymers; Controlled release; Host-guest interaction; Drug delivery
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Funding
- National Natural Science Foundation of China [21576295]
- Open -End Fund for the Valuable, Precision Instruments of Central South University [CSUZC201830]
- Fundamental Research Funds for the Central Universities of Central South University [2017zzts175, 2018zzts371]
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Glutathione (GSH)/light dual-responsive supramolecular drug carriers (abbreviated as CPAP) based on CD-PEGD superset of PCL were fabricated for intracellular delivery of doxorubicin (DOX). The carriers were spherical with a diameter of 70-90 nm and exhibited GSH/light sensitivity. The GSH response attributed to disulfide bonds between PEG and beta-cyclodextrin (beta-CD), and the light response was achieved by a simple host-guest interaction between beta-CD and azobenzene. DOX was encapsulated into the hydrophobic core of CPAP. The drug loaded CPAP (CPAP@DOX) displayed the fastest drug release in the presence of GSH and light simultaneously. The cytotoxicities of CPAP and CPAP@DOX were explored by SKOV3 cells and HEK293T cells. The results of cell experiments indicated that CPAP@DOX could effectively inhibit cancer cells while had reduced toxicity to normal cells. We believe that CPAP@DOX drug delivery system may present promising application for precisely controllable drug release. (C) 2019 Elsevier Ltd. All rights reserved.
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