Article
Nutrition & Dietetics
Lindsay C. Czuba, Emily E. Fay, Jeffrey LaFrance, Chase K. Smith, Sara Shum, Sue L. Moreni, Jennie Mao, Nina Isoherranen, Mary F. Hebert
Summary: This study aims to investigate the changes in maternal vitamin A levels during pregnancy. The findings reveal that plasma retinol concentrations are lower, but all-trans-retinoic acid concentrations are higher during pregnancy.
Article
Biochemistry & Molecular Biology
Jin Dai, Nansi S. Boghossian, Mark A. Sarzynski, Feng Luo, Xiaoqian Sun, Jian Li, Oliver Fiehn, Jihong Liu, Liwei Chen
Summary: In this metabolome-wide association study, metabolomic markers associated with excessive gestational weight gain (GWG) were identified. Novel metabolites in the first and third trimesters were found to be associated with GWG, shedding light on the pathophysiology of GWG.
Article
Nutrition & Dietetics
Ella Koivuniemi, Kathryn Hart, Natalia Mazanowska, Stefania Ruggeri, Bernadette Egan, Laura Censi, Romana Roccaldo, Lilja Mattila, Pasquale Buonocore, Eliisa Loyttyniemi, Monique M. Raats, Miroslaw Wielgos, Kirsi Laitinen
Summary: The study aimed to investigate the use of food supplements and the awareness of recommendations among pregnant women in four European countries. The majority of participants used food supplements during pregnancy, with prenatal multivitamins being the most commonly used type. However, there were discrepancies in knowledge and adherence to recommended intakes, indicating a need for improved assessment and monitoring of supplement use in antenatal care.
Article
Immunology
Victoria Peer, Khitam Muhsen, Moshe Betser, Manfred S. Green
Summary: Pregnant women have lower immune response to pertussis vaccination compared to non-pregnant women, possibly due to higher levels of hormones during pregnancy. Sex hormones during pregnancy, such as progesterone and estrogen, are negatively associated with anti-pertussis toxin antibody levels.
Article
Endocrinology & Metabolism
Ehsan Motevalizadeh, Andres Diaz-Lopez, Francisco Martin, Josep Basora, Victoria Arija
Summary: This study examines the association between parity and early-pregnancy insulin resistance, and finds that multiparous women are more likely to have insulin resistance, with an increased risk proportional to the number of births. Additionally, overweight/obesity appears to aggravate this relationship.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Neurosciences
Ute Habel, Christina Regenbogen, Catharina Kammann, Susanne Stickel, Natalia Chechko
Summary: Female chemical signals can influence male behavior, and this study found that body odors of women during ovulation and pregnancy have different effects on heterosexual men's behavior. The results showed that men were more likely to perceive a woman as pregnant when exposed to body odors from pregnant women, and ovulation body odors activated brain regions associated with face processing and reward, while pregnancy body odors activated regions linked to empathy and prosocial behavior.
Article
Oncology
Dongsheng Chen, Wei Wang, Linlin Wu, Langchao Liang, Shiyou Wang, Yunfeng Cheng, Tongda Zhang, Chaochao Chai, Qiuhong Luo, Chengcheng Sun, Wandong Zhao, Zhiyuan Lv, Ya Gao, Xiaoxia Wu, Ning Sun, Yiwei Zhang, Jing Zhang, Yixuan Chen, Jianing Tong, Xiangdong Wang, Yong Bai, Chaoyang Sun, Xin Jin, Jianmin Niu
Summary: This study constructed a single-cell atlas of peripheral blood mononuclear cells (PBMCs) in pregnant women and identified immune cell reconfiguration during pregnancy. The researchers also developed a model to predict gestational age of normal pregnancy using transcriptomic data.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Molly J. Stout, Anoop K. Brar, Brandi N. Herter, Ananda Rankin, Kristine M. Wylie
Summary: Nucleic acid from viruses is common in peripheral blood, even in asymptomatic individuals. How physiologic changes of pregnancy impact host-virus dynamics for acute, chronic, and latent viral infections is not well described. Our study found that Black race was associated with higher viral richness in maternal blood samples during pregnancy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Oncology
Victoria L. Parker, Bryony F. Cushen, Eleftherios Gavriil, Benjamin Marshall, Sarah Waite, Allan Pacey, Paul R. Heath
Summary: The study compared the performance of two commercially available miRNA extraction kits and found them to be equivalent in terms of miRNA recovery. Optimization attempts did not improve miRNA content, with the Qiagen kit showing slightly better stability. The standard methodology of either kit would be suitable for the investigation of miRNA biomarkers in a healthy pregnant population.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Hematology
Christina Crossette-Thambiah, Phillip Nicolson, Indika Rajakaruna, Alexander Langridge, Zara Sayar, Maria R. Perelta, Sarah Essex, Roderick Oakes, Philip Mounter, Sarah Lewis, Tina Dutt, Ian Scott, Nini Aung, Susie Shapiro, Mike Laffan, Deepa R. J. Arachchillage
Summary: This retrospective observational study compared the clinical characteristics and outcomes of pregnant women and non-pregnant women hospitalized for COVID-19. Differences in blood parameters were observed between pregnant and non-pregnant women on admission, but similar durations of hospitalization and rates of thrombosis were found between the two groups.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Environmental Sciences
Junnan Yang, Mengyu Chu, Chen Gong, Xian Gong, Bin Han, Li Chen, Jianmei Wang, Zhipeng Bai, Yujuan Zhang
Summary: This study found an association between exposure to fine particulate matter (PM2.5) and oxidative protein damage in early pregnant women, especially in those with clinically recognized early pregnancy loss (CREPL). The results showed that PM2.5 and nitrogen dioxide (NO2) exposure were associated with increased levels of serum 3-nitrotyrosine (3-NT) and advanced oxidation protein products (AOPP). The study also identified combustion PM2.5 as the crucial component. Therefore, wearing masks may potentially help prevent PM2.5 exposure and its related oxidative protein damage.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Barrett M. Welch, Alexander P. Keil, Paige A. Bommarito, Thomas Joost van T' Erve, Leesa J. Deterding, Jason G. Williams, Fred B. Lih, David E. Cantonwine, Thomas F. McElrath, Kelly K. Ferguson
Summary: Exposure to consumer product chemicals during pregnancy may increase susceptibility to pregnancy disorders by influencing maternal inflammation. Oxylipins are important mediators of inflammation and adverse pregnancy outcomes have been associated with circulating oxylipin levels. This study found positive associations between urinary biomarkers of consumer product chemicals and pro-inflammatory oxylipins, with different associations depending on the chemical class of exposure biomarker. Associations varied by class of chemical and by the biosynthetic pathway of oxylipin production, suggesting potential specificity in the inflammatory effects of these environmental chemicals during pregnancy.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Biophysics
Preetha Ramachandra, Pratap Kumar, Kari Bo, G. Arun Maiya
Summary: The study compared postural sway between pregnant and non-pregnant women in eight different sensory conditions. Pregnant women demonstrated larger velocity moment and anteroposterior sway velocity across all tested sensory conditions compared to non-pregnant women. Although there was no significant difference in mediolateral sway velocity, ANCOVA results suggested a significant difference in mediolateral sway velocity between pregnant and non-pregnant women in certain sensory conditions. Pregnant women in their third trimester exhibited greater velocity moment and anteroposterior sway velocity compared to non-pregnant women in different sensory conditions.
JOURNAL OF BIOMECHANICS
(2023)
Review
Obstetrics & Gynecology
Anna Elizabeth Crossland, Lydia Munns, Elizabeth Kirk, Catherine Elizabeth Jane Preston
Summary: This study assessed the effect of pregnancy on body image dissatisfaction by synthesising the current literature. The analysis showed no statistical difference in body image dissatisfaction between pregnant women and non-pregnant women. The findings suggest that any changes in body image during pregnancy are heterogeneous and dependent on individual experiences and other factors.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Chemistry, Analytical
Jhohann Richard de Lima Benzi, Adriana Rocha, Julia Cristina Colombari, Alef Machado Gomes Pego, Patricia Pereira dos Santos Melli, Geraldo Duarte, Vera Lucia Lanchote
Summary: This study developed and validated methods for the analysis of Furosemide (FUR) and its glucuronide metabolite (FUR-GLU) in various matrices. These methods can facilitate the investigation of UGT1A9/1A1 and the fraction unbound (fu) when FUR is used as a probe for the renal transporters OAT1 and OAT3.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Editorial Material
Obstetrics & Gynecology
Piya Chaemsaithong, Roberto Romero, Waranyu Lertrut, Arunee Singsaneh, Pisut Pongchaikul
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Dahiana M. Gallo, Roberto Romero, Mariachiara Bosco, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Marcia Arenas-Hernandez, Eunjung Jung, Manaphat Suksai, Francesca Gotsch, Offer Erez, Adi L. Tarca
Summary: The study found that pregnant women with severe PPH had higher median maternal plasma concentrations of IL-16, IL-6, IL-12/IL-23p40, MCP-1, and IL-1 beta than patients without PPH. These cytokines could serve as biomarkers or therapeutic targets.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Nandor Gabor Than, Roberto Romero, Daniel Gyorffy, Mate Posta, Gaurav Bhatti, Bogdan Done, Piya Chaemsaithong, Eunjung Jung, Manaphat Suksai, Francesca Gotsch, Dahiana M. Gallo, Mariachiara Bosco, Bomi Kim, Yeon Mee Kim, Tinnakorn Chaiworapongsa, Simona W. Rossi, Andras Szilagyi, Offer Erez, Adi L. Tarca, Zoltan Papp
Summary: This study identified different molecular subclasses of preeclampsia through longitudinal proteomic profiling, laying the foundation for the development of new diagnostic and personalized tools for prevention.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Tinnakorn Chaiworapongsa, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Dahiana M. Gallo, Eunjung Jung, Arthur Krieger, Piya Chaemsaithong, Offer Erez, Adi L. Tarca
Summary: This study aimed to determine the prevalence, characteristics, and clinical significance of angiogenic/antiangiogenic factor abnormalities in women with preeclampsia stratified according to gestational age at delivery. The results showed that patients with early preeclampsia had an abnormal angiogenic profile in virtually all cases, whereas only 50% of women with preeclampsia at term had such abnormalities. These findings have implications for future clinical care and research.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Letter
Obstetrics & Gynecology
Bo Hyun Yoon, Roberto Romero, Kyung Joon Oh, Hyeon Ji Kim, Eunjung Jung, Francesca Gotsch
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Roberto Romero
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Tomi Kanninen, Eunjung Jung, Dahiana M. Gallo, Ramiro Diaz-Primera, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Mariachiara Bosco, Tinnakorn Chaiworapongsa
Summary: Preeclampsia and fetal growth disorders are pregnancy-specific conditions that share common pathophysiological mechanisms. This study suggests that the severity of the maternal inflammatory response is highest in patients with preeclampsia, while patients with an SGA fetus also show elevated inflammatory response.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero
Summary: This review examines the efficacy of vaginal progesterone (VP) in preventing preterm birth (PTB) in different subsets of high-risk women. The evidence suggests that VP is effective in reducing the risk of PTB and improving perinatal outcomes in certain groups, such as singleton gestations with a short cervix. However, further research is needed to determine its efficacy in other high-risk groups.
JOURNAL OF PERINATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Dahiana M. Gallo, Roberto Romero, Mariachiara Bosco, Francesca Gotsch, Sunil Jaiman, Eunjung Jung, Manaphat Suksai, Carlos Lopez Ramon y Cajal, Bo Hyun Yoon, Tinnakorn Chaiworapongsa
Summary: Green-stained amniotic fluid, also known as meconium-stained amniotic fluid, is a common obstetric hazard. It can be caused by the passage of fetal colonic content or intraamniotic bleeding. Birth with green-stained amniotic fluid is associated with fetal acidemia and potential complications like respiratory distress and seizures. Infection/inflammation inside the amniotic fluid plays a role in the development of meconium-stained amniotic fluid and can lead to clinical chorioamnionitis and neonatal sepsis.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero, Anoop Rehal, Maria L. Brizot, Vicente Serra, Eduardo Da Fonseca, Elcin Cetingoz, Argyro Syngelaki, Alfredo Perales, Sonia S. Hassan, Kypros H. Nicolaides
Summary: This study evaluated the efficacy of vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in twin pregnancies. The results showed that vaginal progesterone did not prevent preterm birth or improve perinatal outcomes in unselected twin pregnancies. However, it appeared to reduce the risk of preterm birth and neonatal morbidity and mortality in twin pregnancies with a sonographic short cervix.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Microbiology
Jonathan J. Panzer, Roberto Romero, Jonathan M. Greenberg, Andrew D. Winters, Jose Galaz, Nardhy Gomez-Lopez, Kevin R. Theis
Summary: The existence of a microbiota in the human placenta is still debated. Recent DNA sequencing investigations reported the presence of a microbiota in typical human term placentas, but it could be background DNA or contamination. Re-analysis of publicly available 16S rRNA gene datasets showed that Lactobacillus, a vaginal bacterium, was highly abundant in placentas but disappeared after applying DNA contaminant removal. Furthermore, bacterial profiles of placental samples clustered primarily by study origin and mode of delivery, suggesting that placentas delivered at term are unlikely to be the original source of observed bacterial DNA signals.
Article
Obstetrics & Gynecology
Ray Bahado-Singh, Adi L. Tarca, Yasmin G. Hasbini, Robert J. Sokol, Madhurima Keerthy, Gregory Goyert, Theodore Jones, Lisa Thiel, Pooja Green, Youssef Youssef, Courtney Townsel, Shyla Vengalil, Paige Paladino, Amy Wright, Mariam Ayyash, Gayathri Vadlamud, Marta Szymanska, Sonia Sajja, Onur Turkoglu, Grace Sterenberg, Alexandra R. Mangus, Micheal Baracy, Maria Gibbons, Karlee Grace, Kaitlyn Houston, Jessica Norman, Dereje W. Gudicha, Sonia S. Hassan
Summary: This study aimed to determine the impact of COVID-19 on preterm birth and found that COVID-19 is an independent risk factor for preterm birth, with medically indicated delivery being the primary driver.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Letter
Obstetrics & Gynecology
Piya Chaemsaithong, Piroon Jenjaroenpun, Pisut Pongchaikul, Arunee Singsaneh, Iyarit Thaipisuttikul, Roberto Romero, Thidathip Wongsurawat
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Priya Prasad, Roberto Romero, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Anderson Lo, Jose Galaz, Andreea B. B. Taran, Eunjung Jung, Francesca Gotsch, Nandor Gabor Than, Adi L. L. Tarca
Summary: Approximately 47% of women with preterm labor deliver at term, but their infants are at higher risk for being small for gestational age and having neurodevelopmental disorders. This study tested the involvement of components of the insulin-like growth factor system in preterm labor and found higher levels of certain components in women with a history of preterm labor.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Medicine, Research & Experimental
Nardhy Gomez-Lopez, Roberto Romero, Maria Fernanda Escobar, Javier Andres Carvajal, Maria Paula Echavarria, Ludwig L. Albornoz, Daniela Nasner, Derek Miller, Dahiana M. Gallo, Jose Galaz, Marcia Arenas-Hernandez, Gaurav Bhatti, Bogdan Done, Maria Andrea Zambrano, Isabella Ramos, Paula Andrea Fernandez, Leandro Posada, Tinnakorn Chaiworapongsa, Eunjung Jung, Valeria Garcia-Flores, Manaphat Suksai, Francesca Gotsch, Mariachiara Bosco, Nandor Gabor Than, Adi L. Tarca
Summary: In this study, the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls was characterized. The findings revealed shared and pregnancy-specific proteomic changes in COVID-19 patients compared to controls, and the plasma proteome accurately identifies COVID-19 patients, even when they are asymptomatic. This study provides insight into the pathogenesis of COVID-19 and explains the more severe outcomes observed in pregnant women.
COMMUNICATIONS MEDICINE
(2023)