Article
Biology
Constantino Fernandez Rivera, Catuxa Rodriguez Magarinos, Maria Calvo Rodriguez, Tamara Ferreiro Hermida, Marta Blanco Pardo, Andres Lopez Muniz, Sara Erraez Guerrero, Leticia Garcia Gago, Angel Alonso Hernandez
Summary: Desensitization allows HLA-incompatible transplants, but the incidence of acute rejection is high. This study found that the incidence of acute antibody-mediated rejection after desensitization was 7.4%. Antibody-mediated rejection mainly occurred in patients with high antibody titers and was associated with early graft loss.
Article
Medicine, General & Internal
Saifu Yin, Qiling Tan, Youmin Yang, Fan Zhang, Turun Song, Yu Fan, Zhongli Huang, Tao Lin, Xianding Wang
Summary: This study explored the efficacy and safety of an individualized preconditioning regimen for ABO-incompatible (ABOi) kidney transplantation. The results showed that the regimen achieved comparable graft and patient survival rates as ABO-compatible (ABOc) kidney transplantation, and effectively prevented acute rejection (AR). However, monitoring antibody titer rebound is necessary.
CHINESE MEDICAL JOURNAL
(2022)
Article
Health Care Sciences & Services
Wei-Chen Lee, Chen-Fang Lee, Tsung-Han Wu, Hao-Chien Hung, Jin-Chiao Lee, Yu-Chao Wang, Chih-Hsien Cheng, Ting-Jung Wu, Hong-Shiue Chou, Kun-Ming Chan
Summary: ABO incompatible living donor liver transplantation can be successful, but anti-ABO isoagglutinin rebound may lead to antibody-mediated rejection and graft loss. Adding bortezomib to the desensitization regimen can mitigate the risk of isoagglutinin rebound and prevent clinical AMR in patients with high isoagglutinin titers.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Editorial Material
Surgery
Daisuke Nakajima, Itsuki Yuasa, Hidenao Kayawake, Satona Tanaka, Yoshito Yamada, Yojiro Yutaka, Masatsugu Hamaji, Akihiro Ohsumi, Tadashi Ikeda, Takenori Suga, Shiro Baba, Hidefumi Hiramatsu, Hiroshi Date
Summary: This article reports a successful case of ABO-incompatible living-donor lobar lung transplantation in a 14-year-old girl with bronchiolitis obliterans due to graft-versus-host disease after hematopoietic stem cell transplantation. The patient received a right lower lobe from her blood type B father and a left lower lobe from her blood type O mother. Prior to transplantation, desensitization therapy with rituximab, immunosuppressants, and plasmapheresis was implemented to reduce the production of anti-B antibodies and prevent acute antibody-mediated rejection.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Letter
Pediatrics
Neelam Mohan, Veena Raghunathan, Maninder Singh Dhaliwal, Prashant Bhangui, Aseem Tiwari, Arvinder S. Soin
Summary: Pediatric ABO-incompatible liver transplantation in India has shown high success rates with the use of plasmapheresis, optimal immune-suppression, and vigilant post-operative monitoring. Successful outcomes were achieved in all 8 patients studied, with no rejection or biliary issues post-transplant.
Article
Pediatrics
Catherine de Magnee, Louise Brunee, Roberto Tambucci, Aurore Pire, Isabelle Scheers, Etienne M. Sokal, Pamela Baldin, Francis Zech, Stephane Eeckhoudt, Raymond Reding, Xavier Stephenne
Summary: ABO-incompatible living donor liver transplantation is a feasible option for pediatric end-stage liver disease, but it carries increased risks for the recipient, especially for children older than 1 year. C4d immunostaining may be a hallmark of acute humoral rejection in ABO-incompatible liver transplantation.
Article
Urology & Nephrology
Tai Yeon Koo, Ju Han Lee, Sang-Il Min, Yonggu Lee, Myung Soo Kim, Jongwon Ha, Soon Il Kim, Curie Ahn, Yu Seun Kim, Jayoun Kim, Kyu Ha Huh, Jaeseok Yang
Summary: HLA-incompatible living donor kidney transplantation may have better patient survival rate and survival benefit compared to waiting for HLA-compatible deceased donor kidney transplantation for sensitized patients with kidney failure in Korea.
KIDNEY INTERNATIONAL
(2021)
Article
Surgery
Wei-Chen Lee, Chih-Hsien Cheng, Chen-Fang Lee, Hao-Chien Hung, Jin-Chiao Lee, Tsung-Han Wu, Yu-Chao Wang, Ting-Jung Wu, Hong-Shiue Chou, Kun-Ming Chan
Summary: A rapid preparation regimen with bortezomib injection and plasma exchange was designed to reduce isoagglutinin titers quickly for ABO-I LDLT in acute liver failure patients, leading to a high success rate in the transplant surgery.
CLINICAL TRANSPLANTATION
(2022)
Article
Immunology
Fan Zhang, Saifu Yin, Yu Fan, Turun Song, Zhongli Huang, Jiayu Liang, Jiapei Wu, Youmin Yang, Tao Lin, Xianding Wang
Summary: This study found that the secretor status of both donors and recipients may have an impact on the outcomes of ABO incompatibility kidney transplantation. Recipients with weak secretor status may have better post-transplant renal function, while recipients from secretor donors had a lower incidence of graft rejection in the first year after transplantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Transplantation
Covadonga Lopez del Moral, Kaiyin Wu, Marcel Naik, Bilgin Osmanodja, Aylin Akifova, Nils Lachmann, Diana Stauch, Sabine Hergovits, Mira Choi, Friederike Bachmann, Fabian Halleck, Eva Schrezenmeier, Danilo Schmidt, Klemens Budde
Summary: This study found that renal function, proteinuria, and rejection are strongly associated with graft failure in patients with dnDSAs and may serve as surrogate endpoints.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Brian D. Cone, Jennifer Q. Zhang, Rebecca A. Sosa, Fiorella Calabrese, Elaine F. Reed, Gregory A. Fishbein
Summary: This study revealed a positive correlation between de novo DSA and p-S6RP expression in pneumocytes and macrophages using IHC. p-S6RP was found to be relatively sensitive, specific, and had superior inter-rater reliability compared to C4d.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Oncology
Koji Natsuda, Takahiro Murokawa, Kwang-Woong Lee, Kyung Chul Yoon, Suk Kyun Hong, Jeong-Moo Lee, Jae-Hyung Cho, Nam-Joon Yi, Kyung-Suk Suh
Summary: The tailored desensitization protocol for ABO-incompatible living donor liver transplantation (ABOi LDLT) with optional intravenous immunoglobulin (IVIG) and/or simultaneous splenectomy showed excellent outcomes without diffuse intrahepatic biliary stricture (DIHBS), comparable to ABO-compatible LDLT.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Urology & Nephrology
Atit A. Dharia, Michael Huang, Michelle M. Nash, Niki Dacouris, Jeffrey S. Zaltzman, G. V. Ramesh Prasad
Summary: Individual kidney transplant survival varies widely due to recipient and donor factors. Compared to actualized living donors, recipients with potential but non-actualized living donors exhibit similar mid-term graft and patient survival. Having an identified living donor is associated with a favorable prognosis for the recipient.
Review
Immunology
Maria Jose Perez-Saez, Nuria Montero, Laia Oliveras, Dolores Redondo-Pachon, David Martinez-Simon, Daniel Abramovicz, Umberto Maggiore, Christophe Mariat, Geir Mjoen, Gabriel C. Oniscu, Licia Peruzzi, Mehmet Sukru Severi, Bruno Watschingerj, Arzu Velioglu, Erol Demir, Ilaria Gandolfini, Rachel Hellemans, Luuk Hilbrands, Julio Pascual, Marta Crespo
Summary: There is a lack of sufficient evidence to support specific immunosuppression treatments for HLA identical sibling kidney transplant recipients. The current research mainly focuses on comparing different immunosuppression strategies and assessing patients with different immunological risks. However, the evidence from these studies is relatively poor and there is a lack of evaluation using modern immunological risk assessment tools.
TRANSPLANTATION REVIEWS
(2023)
Article
Medicine, General & Internal
Hyeyeon Cho, Jinyoung Bae, Hyun-Kyu Yoon, Ho-Jin Lee, Seong-Mi Yang, Suk Hyung Choe, Chul-Woo Jung, Kyung-Suk Suh, Won Ho Kim
Summary: High preoperative and postoperative peak Ig M isoagglutinin titers were significantly associated with the risk of acute kidney injury (AKI) in ABO-incompatible liver transplantation. However, no significant differences were observed in other clinical outcomes based on isoagglutinin titers. This suggests that high isoagglutinin titers may serve as a warning sign for AKI risk after liver transplantation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Yusuke Tomita, Tamotsu Tojimbara, Kazuhiro Iwadoh, Ichiro Nakajima, Shohei Fuchinoue
Review
Immunology
Joseph R. Scalea, Yusuke Tomita, Christopher R. Lindholm, William Burlingham
FRONTIERS IN IMMUNOLOGY
(2016)
Article
Surgery
Mitsuhiro Sekijima, Hisashi Sahara, Katsuyuki Miki, Vincenzo Villani, Yuichi Ariyoshi, Takehiro Iwanaga, Yusuke Tomita, Kazuhiko Yamada
JOURNAL OF SURGICAL RESEARCH
(2017)
Article
Immunology
Y. Tomita, T. Tojimbara, K. Iwadoh, I. Nakajima, S. Fuchinoue
TRANSPLANTATION PROCEEDINGS
(2017)
Article
Medicine, Research & Experimental
Hisashi Sahara, Mitsuhiro Sekijima, Yuichi Ariyoshi, Akihiro Kawai, Kohei Miura, Shiori Waki, Louras Nathan, Yusuke Tomita, Takehiro Iwanaga, Kazuaki Nakano, Hitomi Matsunari, Hiroshi Date, Hiroshi Nagashima, Akira Shimizu, Kazuhiko Yamada
XENOTRANSPLANTATION
(2018)
Article
Immunology
H. Shirai, M. Suzuki, Y. Tomita, K. Iwadoh, K. Kai, A. Sannomiya, I. Koyama, I. Nakajima, S. Fuchinoue
TRANSPLANTATION PROCEEDINGS
(2012)
Article
Immunology
Y. Tomita, K. Iwadoh, K. Kutsunai, I. Koyama, I. Nakajima, S. Fuchinoue
TRANSPLANTATION PROCEEDINGS
(2014)
Article
Immunology
Yusuke Tomita, Kazuhiro Iwadoh, Akiko Hoshino, Yuichi Ogawa, Akihito Sannomiya, Ichiro Nakajima, Shohei Fuchinoue
TRANSPLANTATION PROCEEDINGS
(2019)
Article
Cell Biology
Jeremy A. Sullivan, Yusuke Tomita, Ewa Jankowska-Gan, Diego A. Lema, Matt P. Arvedson, Ashita Nair, William Bracamonte-Baran, Ying Zhou, Kristy K. Meyer, Weixiong Zhong, Deepali V. Sawant, Andrea L. Szymczak-Workman, Qianxia Zhang, Creg J. Workman, Seungpyo Hong, Dario A. A. Vignali, William J. Burlingham
Article
Immunology
Yusuke Tomita, Hiroaki Ishida, Saeko Uehara, Shinya Takiguchi, Takehito Sato, Michio Nakamura
Summary: Regulatory T cell subsets play a crucial role in antigen-specific antibody formation in kidney transplant recipients. Lower frequencies of CD25highCD127-CD4+ Treg cells were observed in recipients with de novo donor-specific anti-HLA antibodies (dnDSA). Activated Treg cells, specifically CD45RA-CD25highCD127-CD4+ cells, were significantly dominant in patients with dnDSA, suggesting a potential risk factor for antibody-mediated rejection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Shinya Takiguchi, Yusuke Tomita, Saeko Uehara, Koichiro Tateishi, Norio Yamamoto, Michio Nakamura
Summary: Immunological response after two doses of SARS-CoV-2 mRNA vaccination is impaired in kidney transplant recipients, indicating the need for modified vaccination strategies.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Yusuke Tomita, Saeko Uehara, Shinya Takiguchi, Michio Nakamura
Summary: This study evaluates the regulatory benefits of mTOR inhibitors in kidney transplant recipients by examining T-cell subsets and found that the early introduction of mTOR benefits long-term kidney graft function and circulating activated Treg-cell expansion.
TRANSPLANTATION PROCEEDINGS
(2023)
Article
Transplantation
Yusuke Tomita, Miwa Satomi, William Bracamonte Baran, Ewa Jankowska Gan, Andrea Szymczak Workman, Creg J. Workman, Dario Angelo Alberto Vignali, William J. Burlingham
TRANSPLANTATION DIRECT
(2016)
Article
Urology & Nephrology
Yusuke Tomita, Kotaro Kai, Hiroyuki Shirai, Ichiro Nakajima, Saeko Yoshizawa, Hideaki Oda, Shohei Fuchinoue