Cyclosporine A eyedrops with self-nanoemulsifying drug delivery systems have improved physicochemical properties and efficacy against dry eye disease in a murine dry eye model

Once-Daily Cyclosporine-A-MiDROPS for Treatment of Dry Eye Disease

(2018) Terry G. Coursey et al.   Translational Vision Science & Technology

Cyclosporine A delivery to the eye: A comprehensive review of academic and industrial efforts

(2017) Frédéric Lallemand et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Peptide GC31 inhibits chemokines and ICAM-1 expression in corneal fibroblasts exposed to LPS or poly(I:C) by blocking the NF-κB and MAPK pathways

(2017) Shaopin Zhu et al.   EXPERIMENTAL EYE RESEARCH

Goblet Cells Contribute to Ocular Surface Immune Tolerance—Implications for Dry Eye Disease

(2017) Flavia Barbosa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evaluation of Clinical Efficacy and Safety of a Novel Cyclosporin A Nanoemulsion in the Treatment of Dry Eye Syndrome

(2017) Hyun Seung Kim et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

TFOS DEWS II pathophysiology report

(2017) Anthony J. Bron et al.   Ocular Surface

TFOS DEWS II Definition and Classification Report

(2017) Jennifer P. Craig et al.   Ocular Surface

Modern approaches to the ocular delivery of cyclosporine A

(2016) Priyanka Agarwal et al.   DRUG DISCOVERY TODAY

From nanoemulsions to self-nanoemulsions, with recent advances in self-nanoemulsifying drug delivery systems (SNEDDS)

(2016) Fiza Ur Rehman et al.   Expert Opinion on Drug Delivery

In Vitro Inhibition of NFAT5-Mediated Induction of CCL2 in Hyperosmotic Conditions by Cyclosporine and Dexamethasone on Human HeLa-Modified Conjunctiva-Derived Cells

(2016) Elise Warcoin et al.   PLoS One

IL-1β Induces IL-6 production in retinal Müller cells predominantly through the activation of P38 MAPK/NF-κB signaling pathway

(2015) Xiufen Liu et al.   EXPERIMENTAL CELL RESEARCH

Elevated Expression of Matrix Metalloproteinase-9 and Inflammatory Cytokines in Keratoconus Patients Is Inhibited by Cyclosporine A

(2015) R. Shetty et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Efficacy and Safety of Topical 0.05% Cyclosporine Eye Drops in the Treatment of Dry Eye Syndrome: A Systematic Review and Meta-analysis

(2015) Kelvin H. Wan et al.   Ocular Surface

Three-factor response surface optimization of nano-emulsion formation using a microfluidizer

(2014) Saeed Sadeghpour Galooyak et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

miRNA-146 negatively regulates the production of pro-inflammatory cytokines via NF-κB signalling in human gingival fibroblasts

(2014) Yu-feng Xie et al.   Journal of Inflammation-London

Analysis of Tear Cytokines and Clinical Correlations in Sjögren Syndrome Dry Eye Patients and Non–Sjögren Syndrome Dry Eye Patients

(2013) Sang Yeop Lee et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Novel Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Oral Delivery of Cinnarizine: Design, Optimization, and In-Vitro Assessment

(2012) Ahmad Abdul-Wahhab Shahba et al.   AAPS PHARMSCITECH

Impact of process parameters in the generation of novel aspirin nanoemulsions – Comparative studies between ultrasound cavitation and microfluidizer

(2012) Siah Ying Tang et al.   ULTRASONICS SONOCHEMISTRY

Desiccating Stress Induces CD4+ T-Cell–Mediated Sjögren's Syndrome–Like Corneal Epithelial Apoptosis via Activation of the Extrinsic Apoptotic Pathway by Interferon-γ

(2011) Xiaobo Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Effect of back pressure on emulsification of lipid nanodispersions in a high-pressure homogenizer

(2011) Akira Saheki et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Reversibility of Dry Eye Deceleration After Topical Cyclosporine 0.05% Withdrawal

(2011) Sanjay N. Rao   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

The Therapeutic Effect of DA-6034 on Ocular Inflammation via Suppression of MMP-9 and Inflammatory Cytokines and Activation of the MAPK Signaling Pathway in an Experimental Dry Eye Model

(2010) Mi Jeong Seo et al.   CURRENT EYE RESEARCH

Regulation of adaptive immunity by the NLRP3 inflammasome

(2010) Mingkuan Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Clinical Review: Topical Ophthalmic Use of Cyclosporin A

(2010) Canan Asli Utine et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Nano-emulsions and Micro-emulsions: Clarifications of the Critical Differences

(2010) Nicolas Anton et al.   PHARMACEUTICAL RESEARCH

Effects of Sequential Artificial Tear and Cyclosporine Emulsion Therapy on Conjunctival Goblet Cell Density and Transforming Growth Factor-β2 Production

(2009) Stephen C Pflugfelder et al.   CORNEA

Curcumin protects against hyperosmoticity-induced IL-1β elevation in human corneal epithelial cell via MAPK pathways

(2009) Min Chen et al.   EXPERIMENTAL EYE RESEARCH