BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss

Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library

(2018) Spyros Merkouris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms

(2017) M. Charles Liberman et al.   HEARING RESEARCH

Pharmaceutical Characterization of Tropomyosin Receptor Kinase B-Agonistic Antibodies on Human Induced Pluripotent Stem (hiPS) Cell–Derived Neurons

(2017) Stefanie Traub et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Neurotrophin receptor agonists and antagonists as therapeutic agents: An evolving paradigm

(2017) Sylvia Josephy-Hernandez et al.   NEUROBIOLOGY OF DISEASE

Myelin-induced inhibition in a spiral ganglion organ culture – Approaching a natural environment in vitro

(2017) Benedikt Kramer et al.   NEUROSCIENCE

Multiplex quantitative assays indicate a need for reevaluating reported small-molecule TrkB agonists

(2017) Umed Boltaev et al.   Science Signaling

Multiplex quantitative assays indicate a need for reevaluating reported small-molecule TrkB agonists

(2017) Umed Boltaev et al.   Science Signaling

A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth

(2016) Tao Yang et al.   NEUROPHARMACOLOGY

Applying Neurotrophins to the Round Window Rescues Auditory Function and Reduces Inner Hair Cell Synaptopathy After Noise-induced Hearing Loss

(2016) David J. Sly et al.   OTOLOGY & NEUROTOLOGY

Round-window delivery of neurotrophin 3 regenerates cochlear synapses after acoustic overexposure

(2016) Jun Suzuki et al.   Scientific Reports

Self-Reported Hearing Difficulties Among Adults With Normal Audiograms

(2015) Kelly L. Tremblay et al.   EAR AND HEARING

Cochlear neuropathy in human presbycusis: Confocal analysis of hidden hearing loss in post-mortem tissue

(2015) Lucas M. Viana et al.   HEARING RESEARCH

Synaptopathy in the noise-exposed and aging cochlea: Primary neural degeneration in acquired sensorineural hearing loss

(2015) Sharon G. Kujawa et al.   HEARING RESEARCH

Neuronal Survival, Morphology and Outgrowth of Spiral Ganglion Neurons Using a Defined Growth Factor Combination

(2015) Jana Schwieger et al.   PLoS One

A Monoclonal Antibody TrkB Receptor Agonist as a Potential Therapeutic for Huntington’s Disease

(2014) Daniel Todd et al.   PLoS One

Connexin 26 null mice exhibit spiral ganglion degeneration that can be blocked by BDNF gene therapy

(2013) Yohei Takada et al.   HEARING RESEARCH

Changes in responsiveness of rat spiral ganglion neurons to neurotrophins across age: differential regulation of survival and neuritogenesis

(2013) Kenji Kondo et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Protection of Spiral Ganglion Neurons from Degeneration Using Small-Molecule TrkB Receptor Agonists

(2013) Q. Yu et al.   JOURNAL OF NEUROSCIENCE

Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease

(2013) Frank M. Longo et al.   NATURE REVIEWS DRUG DISCOVERY

The Trk A, B, C's of Neurotrophins in the Cochlea

(2012) Steven H. Green et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

7,8,3′-Trihydroxyflavone, a potent small molecule TrkB receptor agonist, protects spiral ganglion neurons from degeneration both in vitro and in vivo

(2012) Qing Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Developmental changes in the responsiveness of rat spiral ganglion neurons to neurotrophic factors in dissociated culture: differential responses for survival, neuritogenesis and neuronal morphology

(2012) Yulian Jin et al.   CELL AND TISSUE RESEARCH

Functional Role of Neurotrophin-3 in Synapse Regeneration by Spiral Ganglion Neurons on Inner Hair Cells after Excitotoxic Trauma In Vitro

(2011) Q. Wang et al.   JOURNAL OF NEUROSCIENCE

Pharmacological characterization of six trkB antibodies reveals a novel class of functional agents for the study of the BDNF receptor

(2010) M Cazorla et al.   BRITISH JOURNAL OF PHARMACOLOGY

TrkB and TrkC agonist antibodies improve function, electrophysiologic and pathologic features in TremblerJ mice

(2010) Zarife Sahenk et al.   EXPERIMENTAL NEUROLOGY

Spiral ganglion cell survival after round window membrane application of brain-derived neurotrophic factor using gelfoam as carrier

(2010) Sarah Havenith et al.   HEARING RESEARCH

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

(2010) Stephen M. Massa et al.   JOURNAL OF CLINICAL INVESTIGATION

Brain-derived neurotrophic factor promotes cochlear spiral ganglion cell survival and function in deafened, developing cats

(2010) Patricia A. Leake et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

(2010) S.-W. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adding Insult to Injury: Cochlear Nerve Degeneration after "Temporary" Noise-Induced Hearing Loss

(2009) S. G. Kujawa et al.   JOURNAL OF NEUROSCIENCE

Appetite Enhancement and Weight Gain by Peripheral Administration of TrkB Agonists in Non-Human Primates

(2008) John C. Lin et al.   PLoS One