4.6 Article

Acetylcholine-mediated top-down attention improves the response to bottom-up inputs by deformation of the attractor landscape

Journal

PLOS ONE
Volume 14, Issue 10, Pages -

Publisher

PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0223592

Keywords

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Funding

  1. ImPACT Program of the Council for Science, Technology and Innovation (Cabinet Office, Government of Japan)
  2. International Research Center for Neurointelligence (WPI-IRCN) at The University of Tokyo Institutes for Advanced Study, JSPS KAKENHI [15H05707]
  3. AMED [JP19dm0307009]
  4. JST CREST, Japan [JPMJCR14D2]
  5. Grants-in-Aid for Scientific Research [15H05707] Funding Source: KAKEN

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To understand the effect of attention on neuronal dynamics, we propose a multi-module network, with each module consisting of fully interconnected groups of excitatory and inhibitory neurons. This network shows transitive dynamics among quasi-attractors as its typical dynamics. When the release of acetylcholine onto the network is simulated by attention, the transitive dynamics change into stable dynamics in which the system converges to an attractor. We found that this network can reproduce three experimentally observed properties of attention-dependent response modulation, namely an increase in the firing rate, a decrease in the Fano factor of the firing rate, and a decrease in the correlation coefficients between the firing rates of pairs of neurons. Moreover, we also showed theoretically that the release of acetylcholine increases the sensitivity to bottom-up inputs by changing the response function.

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