Article
Plant Sciences
Qi-Jing Fan, Gang-Zhong Zhou, Chu-Chu Xi, Bo Niu, Yan-Gang Cao, Fan Zhang, C. Benjamin Naman, Chun-Lei Zhang, Zheng-Yu Cao
Summary: Thirteen new benzamide alkaloids were isolated from Delphinium anthriscifolium. Compound 1 possesses a previously undescribed carbon framework. Compound 2 is an artifact formed during the extraction process. Compound 7 is glycosylated while compound 13 contains a chlorine substituent. Compounds 6, 8, and 10-12 showed significant inhibition of LPS-induced NO production in cells.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Mohammad Alhilal, Yaser A. M. Sulaiman, Suzan Alhilal, Sobhi M. Gomha, Salama A. Ouf
Summary: This study isolated new alkaloids from Delphinium peregrinum and evaluated their antifungal activity against different dermatophyte fungal isolates. Peregrine (2) was found to be the most effective alkaloid, but the application of a mixture of alkaloids showed significant synergistic activity.
Article
Biochemistry & Molecular Biology
Zhuorui Song, Chengfeng Gao, Qinghua Jiang, Jinyu Xu, Liangliang Xiong, Kexin Liu, Dejuan Sun, Hua Li, Lixia Chen
Summary: Six new diterpenoid alkaloids were isolated from Delphinium forrestii var. vride, with forrestline F showing the strongest anti-inflammatory activity. It acted through multiple mechanisms by suppressing inflammatory cytokines, modulating NF-kappa B/MAPK and Nrf2/HO-1 signaling pathways.
Article
Biochemistry & Molecular Biology
Huanhuan Ma, Yunxia Ma, Zeren Dawa, Yufeng Yao, Meiqi Wang, Kaihui Zhang, Chenchen Zhu, Fangle Liu, Chaozhan Lin
Summary: This research identified four novel diterpenoid alkaloids from Delphinium brunonianum with activity reducing hepatocytes lipid accumulation. One of the alkaloids showed the strongest inhibitory effect. The study provides experimental evidence for the chemical composition of D. brunonianum and its potential in treating diseases related to lipid accumulation.
Article
Biochemistry & Molecular Biology
Jin-Bu Xu, Yu-Zhu Li, Shuai Huang, Lin Chen, Yan-Yan Luo, Feng Gao, Xian-Li Zhou
Summary: Seven new diterpenoid alkaloids were isolated from Delphinium grandiflorum, along with eight reaction products and thirteen known compounds. Grandiflonines A and B have a unique C-20 diterpenoid alkaloid skeleton, with the configuration of C-18 inverted. The analgesic and anti-inflammatory activities of these compounds were evaluated, with deoxylappaconitine showing superior analgesic activity compared to lappaconitine.
Article
Plant Sciences
Yang-Li Pu, Ling-Feng Tian, Lin Chen, Meng-Yi Deng, Jiang Xie, Shuai Huang, Xian-Li Zhou
Summary: Three new hetisine type C-20-diterpenoid alkaloids, trichophorines A-C (1-3), were isolated from Delphinium trichophorum, along with nine known alkaloids (4-12). Their structures were determined using spectroscopic methods. None of the compounds showed significant inhibitory activity against LPS-induced NO production in RAW 264.7 macrophage cells.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Ashraf M. A. Qasem, Ziyu Zeng, Michael G. Rowan, Ian S. Blagbrough
Summary: Norditerpenoid alkaloids (NDA) are complex natural products with important pharmacological activities. Research has shown that understanding the metabolism of NDA is crucial for their development as drugs.
NATURAL PRODUCT REPORTS
(2022)
Article
Plant Sciences
Tianpeng Yin, Yuanfeng Yan, Xing Li, Guowei Gong, Wenjun Wang
Summary: Three new diterpenoid alkaloids were isolated from the whole plants of Delphinium tatsienense Franch., a folk medicine in China for wind-toxin syndrome treatment. The structures of these alkaloids were determined through extensive spectroscopic analyses. Their potential anti-inflammatory effects were evaluated against NO production in LPS-stimulated RAW 264.7 macrophages.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Di Jing, Yunhong Zhang, Chang Gong, Kaicheng Du, Yumeng Wang, Lantao Lai, Dali Meng
Summary: This study isolated seven undescribed compounds with medicinal and anti-inflammatory activities from Delphinium kamaonense. In vitro assays showed significant inhibitory effects on nitric oxide, indicating potential anti-inflammatory properties. The mechanism of action may be related to the MAPK signaling pathway. Molecular docking results revealed two promising pharmacophores for the lycaconitine-type C19-diterpenoid alkaloids, namely the uncommon amides and methylenedioxy groups.
Article
Biochemistry & Molecular Biology
Nurfida Ablajan, Wen-Juan Xue, Jiang-Yu Zhao, Abdubakiev Sardorbek, Nurmirza Boymirzayevich Begmatov, Shamansur Sagdullaev, Bo Zhao, Haji Akber Aisa
Summary: A pair of new regioisomeric C-19-diterpenoid alkaloids, Shawurenine C (1a) and Shawurenine D (1b), along with five known C-19-diterpenoid alkaloids (2-6), were isolated from the aerial part of Delphinium shawurense W. T. Wang. The chemical structures of the new compounds were determined through spectroscopic analyses, including HR-ESI-MS and 1D, 2D NMR spectroscopic data. Additionally, the anti-inflammatory and cytotoxic activities of these diterpenoid alkaloids were evaluated.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Organic
Lili Qin, Feng Xing, Lin Chen, Xianli Zhou
Summary: In this study, a new denudatine-type C-20-diterpenoid alkaloid named arcutisine was isolated from the roots of Aconitum fischeri var. arcuatum, along with 24 known compounds. The structures were elucidated through spectroscopic analyses. The isolation of compounds 1 and 2 from natural sources for the first time, and the weak anti-inflammatory activity of compounds 7 and 10 at a concentration of 40 μM were notable findings.
Article
Medicine, Research & Experimental
Yufeng Yao, Yuanyuan Chen, Dawa Zeren, Yunxia Ma, Yuanyuan Xie, Qian Wang, Huanhuan Ma, Meiqi Wang, Fangle Liu, Chenchen Zhu, Chaozhan Lin
Summary: This study investigated the anti-fibrotic effects of five major components from Delphinium trichophorum on fibroblasts for the first time. The results showed that all five compounds could effectively reduce abnormal proliferation of fibroblasts and decrease collagen production. Among them, DTF1 and DTF2 demonstrated superior effectiveness. Further experiments revealed that DTF1 and DTF2 exerted their effects by inhibiting the activation of the TGF-β1/Smad signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Nurfida Ablajan, Bo Zhao, Jiang-Yu Zhao, Bian-Lin Wang, Sh Sh Sagdullaev, H. A. Aisa
Summary: Seven new diterpenoid alkaloids were isolated from the whole plant of Aconitum barbatum var. puberulum, including two with unprecedented carbon skeletons. The structures of these compounds were determined through comprehensive spectroscopic analysis, and the biogenesis pathways of two of them were discussed. Additionally, the antiarrhythmic, cytotoxic, and antimicrobial activities of the isolates were evaluated.
Article
Chemistry, Applied
Zhen-Ling Wan, Min Zhang, Yan Xiao, Lin Chen, Jiang Xie, Shuai Huang, Xian-Li Zhou
Summary: Two unprecedented aconitine-type C19-diterpenoid alkaloids, named refractines A-B (1-2), were isolated from the roots of Aconitum refractum. In addition, 12 known compounds (3-14) were also identified. The structures of these compounds were determined through extensive spectroscopic analyses. The inhibitory activities of all compounds against NO production in LPS induced RAW 264.7 macrophages were tested, and compounds 10 and 14 showed slight inhibition with rates of 29.4% and 22.1% at a concentration of 30 μM, respectively.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Xinyu Li, Meizhen Ye, Feng Gao, Xianli Zhou, Lin Chen, Shuai Huang
Summary: A new C-19-diterpenoid alkaloid named gyalanutine A and fourteen known compounds were isolated from the plant of Delphinium gyalanum. The structure of gyalanutine A was determined to have an unusual lycoctonine-type skeleton. The compounds were tested for acetylcholinesterase inhibitory and anti-inflammatory activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Medicinal
R. F. Mukhamatkhanova, Kh M. Bobakulov, B. S. Okhundedaev, I. D. Sham'yanov, H. A. Aisa, Sh Sh Sagdullaev
CHEMISTRY OF NATURAL COMPOUNDS
(2018)
Article
Chemistry, Medicinal
D. R. Kodirova, Kh A. Rasulova, Sh Sh Sagdullaev, H. A. Aisa
CHEMISTRY OF NATURAL COMPOUNDS
(2018)
Correction
Chemistry, Organic
Li Fei Nie, Guozheng Huang, Khurshed Bozorov, Jiangyu Zhao, Chao Niu, Shamansur S. Sagdullaev, Haji A. Aisa
HETEROCYCLIC COMMUNICATIONS
(2018)
Article
Chemistry, Medicinal
K. A. Eshbakova, R. P. Zakirova, Kh. I. Khasanova, Kh. M. Bobakulov, H. A. Aisa, Sh. Sh. Sagdullaev, A. M. Nosov
CHEMISTRY OF NATURAL COMPOUNDS
(2019)
Article
Chemistry, Medicinal
G. E. Berdimbetova, Sh. Sh. Orazova, N. K. Yuldasheva, Sh. K. Khidoyatova, S. D. Gusakova, Sh. Sh. Sagdullaev
CHEMISTRY OF NATURAL COMPOUNDS
(2019)
Article
Chemistry, Medicinal
D. T. Asilbekova, G. Ozek, T. Ozek, Kh. M. Bobakulov, K. H. C. Baser, Sh. Sh. Sagdullaev
CHEMISTRY OF NATURAL COMPOUNDS
(2019)
Article
Chemistry, Organic
Milandip Karak, Yohei Joh, Khamid U. Khodjaniyazov, Shamansur S. Sagdullaev, Tohru Oishi, Kohei Torikai
Article
Chemistry, Applied
Khayrulla Bobakulov, Gulmira Ozek, Temel Ozek, Daniya T. Asilbekova, Nasrulla D. Abdullaev, Shomansur Sh. Sagdullaev, K. H. C. Baser
JOURNAL OF ESSENTIAL OIL RESEARCH
(2020)
Article
Chemistry, Medicinal
N. Ablajan, B. Zhao, J. Y. Zhao, D. R. Kodirova, Sh. Sh. Sagdullaev, H. A. Aisa
CHEMISTRY OF NATURAL COMPOUNDS
(2020)
Article
Biotechnology & Applied Microbiology
R. P. Zakirova, G. Sobolkova, T. D. Kharitonov, A. M. Nigmatullaev, Sh Sh Sagdullaev, D. Kochkin, A. M. Nosov
APPLIED BIOCHEMISTRY AND MICROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Nurfida Ablajan, Bo Zhao, Jiang-Yu Zhao, Bian-Lin Wang, Sh Sh Sagdullaev, H. A. Aisa
Summary: Seven new diterpenoid alkaloids were isolated from the whole plant of Aconitum barbatum var. puberulum, including two with unprecedented carbon skeletons. The structures of these compounds were determined through comprehensive spectroscopic analysis, and the biogenesis pathways of two of them were discussed. Additionally, the antiarrhythmic, cytotoxic, and antimicrobial activities of the isolates were evaluated.
Article
Chemistry, Medicinal
B. S. Okhundedaev, Kh M. Bobakulov, R. F. Mukhamatkhanova, G. A. Toshtemirova, I. D. Sham'yanov, S. Rustamova, F. M. Tursunkhodzhaeva, N. D. Abdullaev, H. A. Aisa, Sh Sh Sagdullaev
CHEMISTRY OF NATURAL COMPOUNDS
(2021)
Article
Chemistry, Medicinal
Kh Sh Kamoldinov, S. M. Sobirov, Sh Sh Sagdullaev, H. A. Aisa
CHEMISTRY OF NATURAL COMPOUNDS
(2021)
Article
Chemistry, Applied
Nurfida Ablajan, Bo Zhao, Xue Wenjuan, Jiangyu Zhao, Sh Sh Sagdullaev, Zou Guoan, Haji Akber Aisa
Summary: Nineteen compounds, including seventeen alkaloids and two megastigmane type compounds, were isolated from Aconitum barbatum var. puberulum Ledeb. Compound 5 displayed mild cytotoxicity against Hela cell lines, while compounds 1 and 6 showed strong antibacterial activity against the Gram-positive bacterium, S. aureus.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Yi Zhu, Junlin Wang, Lu Tang, Yuxin Shang, Weiyi Zhao, Wei Zhang, Ping Hai, Yongbiao Zheng, Wenbo Li, Yanfang Su
Summary: One new iridoid glucoside and two new lignan glycosides, along with three known compounds, were isolated from the whole plants of Lancea tibetica. The structures were determined by spectroscopic methods and X-ray crystallographic analysis. One of the new iridoid glucosides and the known compounds exhibited moderate antioxidant activity.
PHYTOCHEMISTRY LETTERS
(2024)
Article
Plant Sciences
Yi Deng, Minghua Chen, Junming Yi, Yuguo Zheng
Summary: This study successfully designed and synthesized a series of quinazolinone derivatives containing purine molecules, and found that some compounds exhibited strong antiviral activity against tobacco mosaic virus. The findings have important implications for further development of antiviral drugs.
PHYTOCHEMISTRY LETTERS
(2024)
