Journal
PHYSIOLOGY
Volume 34, Issue 6, Pages 419-429Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00016.2019
Keywords
lungs; computational models; ventilation; perfusion
Categories
Funding
- Rutherford Discovery Fellowship
- Royal Society of New Zealand
- Medical Technologies Centre of Research Excellence
- National Heart, Lung and Blood Institute [HL-119201]
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Despite a huge range in lung size between species, there is little measured difference in the ability of the lung to provide a well-matched air flow (ventilation) to blood flow (perfusion) at the gas exchange tissue. Here, we consider the remarkable similarities in ventilation/perfusion matching between species through a biophysical lens and consider evidence that matching in large animals is dominated by gravity but in small animals by structure.
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